Assessment of Curcuma longa extract for adulteration with synthetic curcumin by analytical investigations

Girme, Aboli; Saste, Ganesh; Balasubramaniam, Arun; Pawar, Sandeep; Ghule, Chetana; Hingorani, Lal

doi:10.1016/j.jpba.2020.113603

Cited by 26 publications

(20 citation statements)

References 15 publications

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“…A large number of studies have shown that curcumin has anti-inflammatory, antioxidant, antiviral, scavenging oxygen free radicals, antifibrosis, anticoagulation, lipid regulation, and other pharmacological effects. Curcumin has been paid more and more attention by medical workers at home and abroad because of its low toxicity and good safety [ 14 – 16 ]. Curcumin can significantly reduce aortic injury and neovascularization thickness.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Curcumin Improves Pulmonary Hypertension Rats by Regulating Mitochondrial Function

Chen

Jiang

Zhu

et al. 2021

BioMed Research International

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Objective. To investigate the role of curcumin in regulating pathogenesis of pulmonary arterial smooth muscle cells (PASMCs) derived from pulmonary arterial hypertension (PAH) model. Methods. Male Sprague Dawley rats were injected with monocrotaline (MCT) to establish the PAH experimental model. The rats were divided into control group, MCT group, and curcumin group. At the end of the study, hemodynamic data were measured to determine pulmonary hypertension. Proliferation ability of PASMCs, a remodeling indicator of pulmonary artery and right ventricle, was detected. In addition, the morphology and function of mitochondria, antiglycolysis and antiproliferation pathways, and genes were also analyzed. Results. Curcumin may function by reversing MCT-mediated pulmonary vascular remodeling in rats. Curcumin effectively improved pulmonary vascular remodeling, promoted PASMC apoptosis, and protected mitochondrial function. In addition, curcumin treatment suppressed the PI3K/AKT pathway in PASMCs and regulated the expression of antiproliferative genes. Conclusion. Curcumin can improve energy metabolism and reverse the process of PAHS. However, there were side effects of curcumin in MCT-induced rats, suggesting that the dosage should be treated with caution and its toxicological mechanism should be further studied and evaluated.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Curcumin Improves Pulmonary Hypertension Rats by Regulating Mitochondrial Function

Chen

Jiang

Zhu

et al. 2021

BioMed Research International

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“…Many QC laboratories are equipped with UHPLC or HPLC instruments, which facilitate routine analysis. The quantification was done against linearity and calibration curve from UHPLC-PDA for WS, TC, and AR compounds by external standard method [ 42 ]. The WSHA and WSW samples confirmed the presence of eleven specific withanolides and withanosides in it.…”

Section: Resultsmentioning

confidence: 99%

Ayurveda botanicals in COVID-19 management: An in silico multi-target approach

et al. 2021

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The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagious disease. There is an urgent need to find a specific cure for the disease and global efforts are directed at developing SARS-CoV-2 specific antivirals and immunomodulators. Ayurvedic Rasayana therapy has been traditionally used in India for its immunomodulatory and adaptogenic effects, and more recently has been included as therapeutic adjuvant for several maladies. Amongst several others, Withania somnifera (Ashwagandha), Tinospora cordifolia (Guduchi) and Asparagus racemosus (Shatavari) play an important role in Rasayana therapy. The objective of this study was to explore the immunomodulatory and anti SARS-CoV2 potential of phytoconstituents from Ashwagandha, Guduchi and Shatavari using network pharmacology and docking. The plant extracts were prepared as per ayurvedic procedures and a total of 31 phytoconstituents were identified using UHPLC-PDA and mass spectrometry studies. To assess the immunomodulatory potential of these phytoconstituents an in-silico network pharmacology model was constructed. The model predicts that the phytoconstituents possess the potential to modulate several targets in immune pathways potentially providing a protective role. To explore if these phytoconstituents also possess antiviral activity, docking was performed with the Spike protein, Main Protease and RNA dependent RNA polymerase of the virus. Interestingly, several phytoconstituents are predicted to possess good affinity for the three targets, suggesting their application for the termination of viral life cycle. Further, predictive tools indicate that there would not be adverse herb-drug pharmacokinetic-pharmacodynamic interactions with concomitantly administered drug therapy. We thus make a compelling case to evaluate the potential of these Rasayana botanicals as therapeutic adjuvants in the management of COVID-19 following rigorous experimental validation.

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“…The LODs, calculated from a signal-to-noise ratio of 3, were 4.1, 2.6, and 0.4 ng/mL for CUR, DMC, and BMC, respectively. Similarly, in a separate study, Girme and co-workers reported the assessment of adulteration of turmeric extracts with synthetic CUR using HPLC and HPTLC targeting the synthetic intermediate CIMP-1, that is, (1 E ,4 Z )-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl) hexa-1,4-dien-3-one . The authors calculated that the linearity range for CIMP-1 was 1–20, 10–800 μg/mL for CUR, 1.75–140 μg/mL for DMC, and 0.5–40 μg/mL for BMC, respectively.…”

Section: Results and Discussionmentioning

confidence: 99%

Rapid and Sensitive Analytical Assessment of Curcuminoids and Three Common Turmeric Adulterants in a Single Run Using Liquid Chromatography and Tandem Mass Spectrometry

Tareq

Byrdwell

Luthria

2021

ACS Food Sci. Technol.

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In this study, we have developed and validated a liquid chromatography−tandem mass spectrometry (LC−MS/MS) method using a tandem sector quadrupole mass spectrometer to simultaneously detect and quantify three curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) and three of the most common food adulterants, particularly in turmeric, namely, metanil yellow, Sudan I, and Sudan red G using a single 11 min method. The method was validated for linearity, precision, and accuracy. The limit of quantification (LOQ) and the limit of detection (LOD) were determined as 1−2 and 0.1−0.2 ng/mL, respectively, for all six analytes. The method is accurate and precise, with intraday and interday accuracies ranging from 86.4 to 108.1 and from 86.0 to 107.7%, respectively, and intraday and interday coefficients of variation (CVs) ranging from 0.9 to 5.2 and 1.6 to 5.6%, respectively. A simple extraction procedure, easy sample preparation, high sensitivity, and rapid analysis make this method suitable for routine analyses. The validated method was applied to quantify curcuminoids in six commercial turmeric supplements. The amounts of curcuminoids varied significantly (∼30-fold) among the six supplements investigated in the present study. To demonstrate the practical applicability of the validated method, a commercial dietary turmeric supplement was spiked with 0.002− 1% of adulterants, and their concentrations were accurately quantified. This method provides a rapid quantification of the three curcuminoids and three common adulterants simultaneously in a single run.

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Assessment of Curcuma longa extract for adulteration with synthetic curcumin by analytical investigations

Cited by 26 publications

References 15 publications

[Retracted] Curcumin Improves Pulmonary Hypertension Rats by Regulating Mitochondrial Function

[Retracted] Curcumin Improves Pulmonary Hypertension Rats by Regulating Mitochondrial Function

Ayurveda botanicals in COVID-19 management: An in silico multi-target approach

Rapid and Sensitive Analytical Assessment of Curcuminoids and Three Common Turmeric Adulterants in a Single Run Using Liquid Chromatography and Tandem Mass Spectrometry

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