Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis

Motgi, Anagha A; Shete, Mrinal; Chavan, Mahesh; Diwaan, Nikkhiel; Sapkal, Rashmi; Channe, Pallavi

doi:10.4103/jcar.jcar_8_21

Cited by 9 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 6 , 7 However, previous studies have found no significant correlation between clinical and histopathological grading explaining the discordance regarding vascularity. 21 , 24 , 25 …”

Section: Discussionmentioning

confidence: 99%

Correlation between Vascularity and Advancing Histological Grades of Oral Submucous Fibrosis with a Plausible Role in Malignisation

Pandiar,

Nair,

Bologna-Molina

et al. 2024

Sultan Qaboos Univ Med J

View full text Add to dashboard Cite

Objectives: Recent studies showed that as the stage advances there is no significant change in the vascularity as opposed to the conventional concept, thus, the present was designed to quantify the vascularity in histological grades of OSMF and to assess if there is any connection between vasculogenesis and malignisation. Methods: A comprehensive database search was done for published articles on vascularity in oral submucous fibrosis following PRISMA guidelines without date constrains; the search was done till December 2022. The review was registered in Prospero. After screening 607 articles, a total of 13 studies were finally included for systematic evaluation. Results: A total of 607 cases were included, with a definite predilection for the male gender. 11/13 studies evaluated mean vascular density; in more than half, the vascularity decreased as the stage advanced. Similar results were obtained for endothelial cells /square μm, mean vascular area percentage & mean vascular area. Conclusion: The present review supports the prevailing concept that vascularity decreases with advancement of the stage of OSMF, denying systemic absorption of carcinogens into the circulation with resultant longer exposure of compromised epithelium and malignisation. Keywords: Malignisation; Mean Vascular Density; Oral Submucous Fibrosis; OSMF; Vascularity.

show abstract

“… 6 , 7 However, previous studies have found no significant correlation between clinical and histopathological grading explaining the discordance regarding vascularity. 21 , 24 , 25 …”

Section: Discussionmentioning

confidence: 99%

Correlation between Vascularity and Advancing Histological Grades of Oral Submucous Fibrosis with a Plausible Role in Malignisation

Pandiar,

Nair,

Bologna-Molina

et al. 2024

Sultan Qaboos Univ Med J

View full text Add to dashboard Cite

show abstract

“…Other features, such as hyperplasia, hyperkeratosis, and even atypia, may also be seen in the epithelium. The underlying connective tissue may occasionally show chronic inflammatory cell infiltration [16] (Figure 1f).…”

Section: Oral Submucous Fibrosis (Osf)mentioning

confidence: 99%

The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy

Khamis,

Salzer,

Schiegnitz

et al. 2023

IJMS

View full text Add to dashboard Cite

OPMDs (oral potentially malignant disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions to the prevention and therapeutic management of various diseases and neoplastic conditions, including oral cancer. Observational studies suggest correlations between VitD deficiency and higher cancer risk, worse prognosis, and increased mortality rates. Interestingly, emerging data also suggest a link between VitD insufficiency and the onset or progression of OPMDs. Understanding the role of the VitD–VDR axis not only in established oral tumors but also in OPMDs might thus enable early detection and prevention of malignant transformation. With this article, we want to provide an overview of current knowledge about OPMDs and VitD and investigate their potential association and ramifications for clinical management of OPMDs.

show abstract

“…The prevalence of autoimmune diseases is higher among women of childbearing age and the recurrence of these diseases is seen during pregnancy and after childbirth. In fact, women have enhanced immune reactivity, larger antigen-presenting capability, mitogenic responses, increased antibody production, higher immunoglobulin levels, and the ability to reject allografts more rapidly 9 93. The immune system and the neuroendocrine system have many connections.…”

Section: Common Side Effects Of Hyperprolactinemiamentioning

confidence: 99%

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Ghoreshi

Akbari

Sharif-zak

et al. 2022

Journal of Investigative Medicine

View full text Add to dashboard Cite

The prolactin hormone (PRL) is often secreted by lactotrophic cells of the anterior pituitary and has been shown to play a role in various biological processes, including breast feeding and reproduction. The predominant form of this hormone is the 23 kDa form and acts through its receptor (PRLR) on the cell membrane. This receptor is a member of the superfamily of hematopoietic/cytokine receptors. PRL also has a 16 kDa subunit with anti-angiogenic, proapoptotic, and anti-inflammatory effects which is produced by the proteolytic breakdown of this hormone under oxidative stress. Although the common side effects of hyperprolactinemia are exerted on the reproductive system, new studies have shown that hyperprolactinemia has a wide variety of effects, including playing a role in the development of autoimmune diseases and increasing the risk of cardiovascular disease, peripartum cardiomyopathy, and diabetes among others. The range of PRL functions is increasing with the discovery of multiple sites of PRL secretion as well as PRLR expression in various tissues. This review summarizes current knowledge of the biology of PRL and its receptor, as well as the role of PRL in human pathophysiology.

show abstract

Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis

Cited by 9 publications

References 23 publications

Correlation between Vascularity and Advancing Histological Grades of Oral Submucous Fibrosis with a Plausible Role in Malignisation

Correlation between Vascularity and Advancing Histological Grades of Oral Submucous Fibrosis with a Plausible Role in Malignisation

The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Contact Info

Product

Resources

About