Assessment of Correlation Between Acute Viral Hepatitis and Serum Lipid Levels

Abstract

BACKGROUND As liver is an essential organ in lipid metabolism, several stages of lipid synthesis and transportation, it is reasonable to expect an abnormal lipid profile in those with severe liver dysfunction. There is prominent decline in plasma cholesterol and triglyceride (TG) in patients with severe hepatitis and hepatic failure because of reduction of lipoprotein biosynthesis. For reduced liver biosynthesis capacity, low levels of TG and cholesterol is usually observed in chronic liver diseases. This study was conducted to assess the correlation between acute viral hepatitis with serum cholesterol and serum triglyceride values. METHODS This case control study was, conducted among 30 presumptive cases of acute viral hepatitis, who were admitted under the department of general medicine, KIMS, Karad, during the period of October 2015 to March 2017. Probable cases of acute viral hepatitis having clinical symptoms suggestive of hepatitis or liver, consistent with Acute Viral Hepatitis, and those cases that were sero-positive for either Hepatitis-A,-B,-C orE were included in the present study. Similar number of controls (n=30) was selected in the present study. All the controls were matched for non-modifiable risk factors such as age and gender. RESULTS In this study, in patients with acute viral hepatitis in the acute phase, the mean total cholesterol was 169.700 ± 33.225, which was lower in cases than controls. Mean triglyceride was 151.066± 53.677, which was higher in cases than controls. The mean total cholesterol in cases was 32.730 (± 37.863) mg/dl and mean value of triglyceride was + 29.933± 75.019 mg/dl.