Assessment of Coronary Microcirculation with Myocardial Contrast Echocardiography

Trifunović, Danijela; Dudic, J; Olga, Petrovic; Vasiljevic-Pokrajcic, Zorana

doi:10.2174/1381612824666180702115432

Cited by 6 publications

(8 citation statements)

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“…It also contributes to better assessment of LV wall motion abnormality and better assessment of LV anatomy. Contrast echocardiography also offers functional assessment of the complete coronary vasculature, from epicardial coronary arteries downstream to the coronary capillaries 10,11 . In this case, we report the employment of contrast echocardiography in depiction of the coronary artery fistula.…”

Section: Discussionmentioning

confidence: 91%

Diagnosis of left anterior descending branch‐right ventricular fistula with giant coronary artery aneurysm by contrast echocardiography: A case report

Liu

et al. 2022

Echocardiography

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Background Coronary fistulae are communications between a coronary artery and a heart chamber or vessel. The final diagnosis is usually made by coronary angiography or computed tomographic (CT) angiography. Here we report a case by employing contrast echocardiography in diagnosis of a giant coronary aneurysm with right ventricle (RV) fistula. Case presentation The patient, a 29‐year‐old woman, referred to our institution with a complaint of palpitation occasionally. Transthoracic echocardiogram showed a spherical, echogenic structure in the apex of RV. Proximal to the aneurysm, the left anterior descending branch (LAD) remained enlarged (8–9 mm) and showed a fistulous communication with the echogenic structure. A contrast echocardiography was performed, and 4–5 cardiac cycle after the left ventricle was enhanced, the echogenic structure started to become more prominent and several fistulae were seen between RV and the echogenic structure. Computed tomography (CT) angiography and coronary angiography confirmed the dilation (9 mm in diameter) of the LAD with an aneurysm at the distal segment of the LAD, with a small amount of iodinated contrast agent flowing into the subsequent region of the RV, thereby characterizing a LAD‐to‐RV fistula. Conclusion The final diagnosis of fistula is usually made by coronary angiography or CT angiography. However, contrast echocardiography is also a well‐established method for the demonstration of intracardiac shunting. In this case, the contrast echocardiography clearly revealed one of the fistulae between the aneurysm and RV.

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Section: Discussionmentioning

confidence: 91%

Diagnosis of left anterior descending branch‐right ventricular fistula with giant coronary artery aneurysm by contrast echocardiography: A case report

Liu

et al. 2022

Echocardiography

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“…Currently, the indexes commonly used in clinical evaluation of perfusion level include myocardial perfusion color grading;cardiac PET-CT; myocardial contrast echocardiography and TIMI blood ow grading [17][18], both of which are invasive and expensive. Therefore, a simple index that can be used to evaluate the myocardial perfusion level of patients after PCI is needed.…”

Section: Discussionmentioning

confidence: 99%

Serum Triglycerides Fasting Glycemic Product Index Predict No-Reflow Phenomenon in Patients with Actue Myocardial Infarction Undergoing Primary Coronary Intervention

Liao

Yang

et al. 2021

Preprint

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Objective: To investigate the value of serum triglyceride and fasting glycemic index in predicting no reflow in patients with acute myocardial infarction after percutaneous coronary intervention. Methods: A total of 1037 patients with acute myocardial infarction who received PCI in the Department of Cardiology of Shanghai General Hospital and Jiading Branch of Shanghai General Hospital from January 2016 to May 2021 were retrospectively selected. According to postoperative TIMI blood flow classification, all patients were divided into no reflow group (TIMI blood flow≤grade 2) (309 cases) and reflow group (TIMI blood flow = grade 3) (728 cases). Clinical data, laboratory indicators and surgical information were collected from the two groups of patients. Logistic univariate and multivariate regression were used to analyze the independent risk factors of no reflow in actue myocardial infarction patients after PCI. ROC curve was used to analyze the best cut-off point for TyG index to predict the occurrence of no reflow. Results: The TyG index of no reflow group was significantly higher than of reflow group (7.16±0.64 vs 6.63±0.38, P=0.001). Multivariate logistic regression analysis showed that TyG index(OR=1.484,95%Cl 1.203-1.831,P< 0.001);WMSI(OR=2.640,95%Cl1.036-4.722,P=0.039);CSI (OR=2.299,95%Cl1.117-4.767,P=0.022) was independent predictors of no reflow phenomenon in patients with acute myocardial infarction after PCI .The area under the ROC curve predicted by TyG index after PCI without reflow was 0.809,95%Cl(0.740-0.879),higher than CSI and WMSI.When the TyG index was 6.995, the sensitivity and specificity of Youden index were 82.4% and 70.3% respectively at the maximum.Conclusion: TyG index can be used as an indicator to predict the occurrence of no-reflow in patients with acute myocardial infarction after PCI, which is helpful for clinicians to select high-risk patients and take interventions timely, so as to reduce the risk of no-reflow in patients after PCI.

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“…By observing microbubble destruction and replenishment in the myocardium, myocardial contrast echocardiography (MCE) can non-invasively assess myocardial microcirculation perfusion (16). As coronary microcirculation blood flow and microvascular functional integrity are related to myocardial perfusion, MCE also evaluates the function of the complete coronary vascular system (17). Previous research has extensively found that MCE is not inferior to SPECT for the detection of myocardial perfusion (18,19).…”

Section: Introductionmentioning

confidence: 99%

Early and dynamic detection of doxorubicin induced cardiotoxicity by myocardial contrast echocardiography combined with two-dimensional speckle tracking echocardiography in rats

Zhang

Li²,

Liu³

et al. 2023

Front. Cardiovasc. Med.

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BackgroundAnthracycline-induced cardiotoxicity is well-known as a side effect of chemotherapy. Currently, clinical imaging techniques are not capable to detect doxorubicin (DOX)-induced cardiotoxicity before a functional decline. The purpose of this study was to evaluate whether myocardial contrast echocardiography (MCE) can dynamically monitor the cardiac changes in the early stage in the DOX-induced rat model of cardiotoxicity.MethodsA weekly injection of 2.5 mg/kg of DOX was used to generate a rat model of cardiotoxicity. All groups underwent ultrasonic examinations including standard echocardiography, 2D speckle tracking echocardiography (2D-STE), and MCE. Then all rats were sacrificed immediately for histopathological evaluation.ResultsA total of eight control rats and 32 DOX-treated rats were included in the study and grouped according to their treatment period. Decreased quantitative parameters of myocardial blood flow (MBF) (control vs. group 1: 133.31 ± 20.23 dB/s vs. 103.35 ± 21.60 dB/s, P = 0.048) and β (control vs. group 2: 11.17 ± 1.48/s vs. 7.15 ± 1.23/s, P < 0.001) were observed after 2 and 4 weeks of treatment, respectively, while left ventricular global strain (control vs. group 3: −23.67 ± 3.92% vs. −16.01 ± 3.40%, P = 0.002) decreased after 6 weeks of treatment and left ventricular ejection fraction (LVEF) (control vs. group 4: 82.41 ± 3.20% vs. 70.89 ± 9.30%, P = 0.008) decreased after 8 weeks of treatment. The main histopathological features are increased myocardial vacuolization and interstitial fibrosis and decreased myocardial microvessel density.ConclusionCompared with standard echocardiography and 2D-STE, MCE can accurately and non-invasively detect changes in early myocardial perfusion, demonstrating the clinical potential of continuous and dynamic monitoring of DOX-induced cardiotoxicity.

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Assessment of Coronary Microcirculation with Myocardial Contrast Echocardiography

Cited by 6 publications

References 0 publications

Diagnosis of left anterior descending branch‐right ventricular fistula with giant coronary artery aneurysm by contrast echocardiography: A case report

Diagnosis of left anterior descending branch‐right ventricular fistula with giant coronary artery aneurysm by contrast echocardiography: A case report

Serum Triglycerides Fasting Glycemic Product Index Predict No-Reflow Phenomenon in Patients with Actue Myocardial Infarction Undergoing Primary Coronary Intervention

Early and dynamic detection of doxorubicin induced cardiotoxicity by myocardial contrast echocardiography combined with two-dimensional speckle tracking echocardiography in rats

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