Assessment of corneal and lens clarity in children with Wilson disease

Doğuizi, Sibel; Özateş, Serdar; Hoşnut, Ferda Özbay; Şekeroğlu, Mehmet Ali; Yılmazbaş, Pelin

doi:10.1016/j.jaapos.2018.12.010

Cited by 13 publications

(10 citation statements)

References 20 publications

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“…These results highlight the importance of considering age as a confounding factor in densitometry studies. Numerous scientific reports have used corneal densitometry as a tool to investigate eye disease, [7][8][9][10][11][12][13][14][15][16][17][21][22][23][24][25][26][27] but few consider the potential confounding factors as they seemed to take a statistically significant correlation between two parameters at face value (e.g., tilt and densitometry, Figure 2), when it can in fact be explained entirely by a third variable (age). Clinicians need to be mindful of such confounding factors when using densitometry, or any other clinical test, as a discriminative parameter between groups and consider using mediation analyses where needed.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20] An association of corneal densitometry with the disease has been established in multiple myeloma, 21 Fabry disease 22 and other rare disorders. 23,24 Corneal densitometry has been helpful in evaluating corneal integrity after refractive surgery, 25,26 corneal crosslinking 13 and trabeculectomy. 27 Beyond eye disorders and diseases, it has been reported that while corneal densitometry increases with age, 6,[28][29][30] no correlation has been found between corneal keratometry and refractive parameters.…”

Section: Influence Of Eye Tilt On Corneal Densitometrymentioning

confidence: 99%

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Influence of eye tilt on corneal densitometry

Consejo

Jiménez‐García

Rozema

et al. 2022

Ophthalmic Physiologic Optic

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To investigate whether Pentacam densitometry readings are affected by corneal tilt.Methods: In a prospective study, the right eyes of 86 healthy participants aged 42.8 ± 20.0 years (range 18-79 years) were imaged using Scheimpflug tomography.Elevation maps were exported to calculate corneal tilt using custom-made software, and densitometry readings were acquired directly from the corneal densitometry analysis add-on to the standard software Oculus Pentacam HR. Simple mediation analysis was applied to study age as a confounding factor in the correlation between corneal tilt and corneal densitometry.Results: Corneal tilt and corneal densitometry are not independent from one another because age is significantly correlated with both corneal tilt (r = 0.50, p < 0.001) and corneal densitometry (r = 0.91, p < 0.001). Only 3.8% of the correlation between tilt and densitometry operates directly, while the remaining 96.2% depends on age. Conclusions:Corneal tilt plays a role in corneal densitometry readings, even though the interaction is strongly influenced by age. Age is a well-known factor in densitometry readings that should be taken into consideration when interpreting Scheimpflug densitometry.

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Section: Discussionmentioning

confidence: 99%

Section: Influence Of Eye Tilt On Corneal Densitometrymentioning

confidence: 99%

Influence of eye tilt on corneal densitometry

Consejo

Jiménez‐García

Rozema

et al. 2022

Ophthalmic Physiologic Optic

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“…This outcome is explained by the lower degree of corneal lamellar organization in the anterior stroma than in the posterior stroma and the intensity of the keratocyte presence in the superficial stroma [31,32]. The corneal light backscattering is considered an indicator of corneal health; therefore, several studies have been conducted to determine the early subclinical alterations that occur in various ocular diseases [16]- [19,33,34].…”

Section: Discussionmentioning

confidence: 99%

“…Corneal and lens densitometry became popular in recent years to evaluate corneal health in various ocular and systemic disorders. Subclinical corneal and lens densitometry changes were detected in cases with type one-type two diabetes mellitus, rheumatoid arthritis, and Wilson disease [16][17][18][19]. A recently published report about corneal clarity changes in VKC patients showed increased corneal, and lens densitometry in VKC cases as the disease's clinical-grade severity worsens [20].…”

Section: Introductionmentioning

confidence: 98%

Corneal and lens densitometry in patients with vernal keratoconjunctivitis

Yılmaz¹,

İpek²,

Özer

2021

Int Ophthalmol

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Aim To evaluate corneal and crystalline lens densitometry in patients with vernal keratoconjunctivitis (VKC). Methods This is a case-control study. Patients with VKC and age-gender-matched healthy controls underwent a complete ophthalmologic examination with corneal and crystalline lens densitometry measurements. Additionally, the anterior chamber parameters comprise anterior and posterior K mean and astigmatism, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), pachymeter, and corneal volume (CV). Patients who had clinically grade 0 or grade 1 VKC and with only tarsal conjunctiva involvement during the conductance of the study were included. The variables were compared statistically. Results One hundred and nine eyes were included in the study, in which fifty-one were in the VKC group. There were 25 males in the VKC group (26 female) and 22 males in the control group (36 female). A statistically significant difference was found between the groups in terms of posterior corneal astigmatism (p = 0.02). The mean corneal pachymeter, CV, ACD, ACA, and ACV were similar in both groups (p = 0.63, p = 0.26, p = 0.60, p = 0.41, and p = 0.32, respectively). The total mean corneal densitometry in the zones extending from 6 to 10 mm and 10 to 12 mm was increased in the VKC group compared to the control group (p = 0.04 and p = 0.012, respectively). The mean crystalline lens was found to be denser in the VKC group compared to the control group (8.96 ± 1.6 vs. 8.5 ± 0.57, respectively, p = 0.04). Conclusion Posterior corneal astigmatism is increased in VKC cases in comparison with age-and gender-matched controls. The peripheral anterior 6-12 mm annular corneal zone showed increased corneal densitometry in VKC cases compared to the healthy subjects. Additionally, the lens clarity is found to be decreased subclinically in VKC cases compared to control cases. Keywords Vernal keratoconjunctivitis Á Corneal densitometry Á Crystalline lens densitometry Á Anterior chamber depth Á Anterior chamber volume Á Anterior chamber angle Á Pachymeter Á Corneal volume

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“…ATP7B is the causative gene, with more than 500 identified mutations [1]. WD has established ocular manifestations, including Kayser-Fleischer corneal rings, sunflower cataract, and, rarely, night blindness, optic neuritis, optic disc pallor, and exotropia [2].…”

Section: Introductionmentioning

confidence: 99%

Challenges in Management of Rhegmatogenous Retinal Detachment in a Patient With Wilson’s Disease: A Case Report and Literature Review

Alkhuraimi¹,

Alqahtani²,

Alqahtani³

2021

Cureus

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Wilson's disease (WD) is a rare hepatolenticular inherited disorder affecting copper transport resulting in accumulation of copper, which leads to the induction of apoptosis in different organs. Furthermore, patients with WD have elevated cytokines activity responsible for inflammation of various tissues. Here, we report our challenges in managing a case of rhegmatogenous retinal detachment (RRD) in a oneeyed 28-year-old male with WD who had a previous history of severe intraocular inflammation that ended with phthisis bulbi after pars plana vitrectomy for RRD. After one year, he developed RRD in the seeing eye. A decision was made to perform scleral buckling to avoid the risk of postoperative intraocular inflammation. However, a barrage laser was required for shallow retinal detachment in a subsequent follow-up, which was ultimately complicated by severe intraocular inflammation. We observed that our patient with WD had a tendency for severe intraocular inflammation, even following minor non-surgical ophthalmic procedures. For this reason, ophthalmologists need to be aware of managing similar cases and perhaps other diseases associated with elevated levels of cytokines.

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Assessment of corneal and lens clarity in children with Wilson disease

Cited by 13 publications

References 20 publications

Influence of eye tilt on corneal densitometry

Influence of eye tilt on corneal densitometry

Corneal and lens densitometry in patients with vernal keratoconjunctivitis

Challenges in Management of Rhegmatogenous Retinal Detachment in a Patient With Wilson’s Disease: A Case Report and Literature Review

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