Assessment of compressive modulus, hydraulic permeability and matrix content of trypsin-treated nucleus pulposus using quantitative MRI

Périé, Delphine; Iatridis, James C.; Demers, Caroline N.; Goswami, Tapas; Beaudoin, G.; Mwale, Fackson; Antoniou, John

doi:10.1016/j.jbiomech.2005.04.015

Cited by 67 publications

(33 citation statements)

References 34 publications

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“…Preliminary in-vitro work has shown correlations between magnetic resonance images and disc mechanical properties (Campana et al, 2011;Cortes et al, 2014;Mwale et al, 2008;Périé et al, 2006;Recuerda et al, 2012), but in-vivo applications are still lacking. Moreover, cost and accessibility of magnetic resonance imaging represent an issue when considering large scale routine clinical use.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

et al. 2014

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Objectives: Although magnetic resonance is widely spread to qualitatively assess disc morphology, a simple method to reliably determine intervertebral disc status is still lacking. Shear wave elastography is a recent technique that allows quantitative evaluation of soft-tissues mechanical properties; the aim of this study was to preliminary assess the feasibility and reliability of cervical intervertebral disc mechanical characterization by elastography and to provide first reference values for asymptomatic subjects.Methods: Elastographic measurements were performed to determine shear wave speed (SWS) in C6-C7 or C7-T1 disc of forty-seven subjects; repeatability and inter-operator reproducibility were assessed.Results: Global average shear wave speed (SWS) was 3.0 ± 0.4 m/s; measurement repeatability and inter-user reproducibility were 7 and 10 %, respectively. SWS was correlated with both subject's age (p = 1.3e-5) and body mass index (p = 0.008).Conclusions: Shear wave elastography in intervertebral disc proved reliable and allowed stratification of subjects according to age and BMI. Applications could be relevant, for instance, in early detection of disc degeneration or in follow-up after trauma; these results open the way to larger cohort studies to define the place of this technique in routine intervertebral disc assessment.

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Section: Introductionmentioning

confidence: 99%

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

et al. 2014

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“…More invasive measuring techniques are also being explored [23], but they can only be applied during surgery. Direct and non-invasive measurement techniques to assess spine flexibility are still lacking, although preliminary results have been reported in IVD mechanical characterization with magnetic resonance imaging [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Intervertebral disc characterization by shear wave elastography: An in vitro preliminary study

Vergari

Rouch

Dubois

et al. 2014

Proc Inst Mech Eng H

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Science Arts & Métiers (SAM)is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. properties remains a challenge. Ultrasound elastography is a relatively recent measurement technique allowing the evaluation of soft tissue's elastic modulus through the measurement of shear wave speed (SWS). The aim of this study was to determine the feasibility of elastographic measurements in intervertebral disc (IVD). An in-vitro approach was chosen to test the hypothesis that SWS can be used to evaluate IVD mechanical properties and to assess measurement repeatability. Eleven oxtail IVDs were tested in compression to determine their stiffness and apparent elastic modulus at rest and at 400 N. Elastographic measurements were performed in these two conditions and compared to these mechanical parameters. The protocol was repeated six times to determine elastographic measurement repeatability. Average SWS over all samples was 5.3 ± 1.0 m/s, with a repeatability of 7 % at rest and 4.6 % at 400 N; stiffness and apparent elastic modulus were 266.3 ± 70.5 N/mm and 5.4 ± 1.1 MPa at rest, respectively, while at 400 N they were 781.0 ± 153.8 N/mm and 13.2 ± 2.4 MPa. Correlations were found between elastographic measurements and IVD mechanical properties; these preliminary results are promising for further in-vivo application.

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“…However, the limitations of current technology and the complicated anatomy of the lumbar spine have made it difficult to measure the vertebral motion under physiologic loading conditions. In vivo spinal research to date has mainly concentrated on the measurement of range of motion and the evaluation for instability using methods such as bilateral radiographs, magnetic resonance imaging (MRI) [5,11,12,16,29], computerized topography (CT) [32], electrogoniometer [4,10,22,33], and videofluoroscopy [7,17]. For example, early research used plain radiographs to examine the spinal motion of living subjects during flexion-extension positions [27,28].…”

Section: Introductionmentioning

confidence: 99%

Segmental in vivo vertebral motion during functional human lumbar spine activities

et al. 2009

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Quantitative data on the range of in vivo vertebral motion is critical to enhance our understanding of spinal pathology and to improve the current surgical treatment methods for spinal diseases. Little data have been reported on the range of lumbar vertebral motion during functional body activities. In this study, we measured in vivo 6 degrees-of-freedom (DOF) vertebral motion during unrestricted weightbearing functional body activities using a combined MR and dual fluoroscopic imaging technique. Eight asymptomatic living subjects were recruited and underwent MRI scans in order to create 3D vertebral models from L2 to L5 for each subject. The lumbar spine was then imaged using two fluoroscopes while the subject performed primary flexion-extension, left-right bending, and left-right twisting. The range of vertebral motion during each activity was determined through a previously described imagingmodel matching technique at L2-3, L3-4, and L4-5 levels. Our data revealed that the upper vertebrae had a higher range of flexion than the lower vertebrae during flexionextension of the body (L2-3, 5.4 ± 3.8°; L3-4, 4.3 ± 3.4°; L4-5, 1.9 ± 1.1°, respectively). During bending activity, the L4-5 had a higher (but not significant) range of left-right bending motion (4.7 ± 2.4°) than both L2-3 (2.9 ± 2.4°) and L3-4 (3.4 ± 2.1°), while no statistical difference was observed in left-right twisting among the three vertebral levels (L2-3, 2.5 ± 2.3°; L3-4, 2.4 ± 2.6°; and L4-5, 2.9 ± 2.1°, respectively). Besides the primary rotations reported, coupled motions were quantified in all DOFs. The coupled translation in left-right and anterior-posterior directions, on average, reached greater than 1 mm, while in the proximal-distal direction this was less than 1 mm. Overall, each vertebral level responds differently to flexionextension and left-right bending, but similarly to the leftright twisting. This data may provide new insight into the in vivo function of human spines and can be used as baseline data for investigation of pathological spine kinematics.

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Assessment of compressive modulus, hydraulic permeability and matrix content of trypsin-treated nucleus pulposus using quantitative MRI

Cited by 67 publications

References 34 publications

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

Intervertebral disc characterization by shear wave elastography: An in vitro preliminary study

Segmental in vivo vertebral motion during functional human lumbar spine activities

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