Assessment of combined expression of B7-H3 and B7-H4 as prognostic marker in esophageal cancer patients

Chen, Lüjun; Xie, Quanqin; Wang, Zhigang; Shi, Liangrong; Wu, Changping; Jiang, Jingting

doi:10.18632/oncotarget.12628

Cited by 17 publications

(15 citation statements)

References 25 publications

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“…More recently, combination with B7 family molecules has been used to enhance the sensitivity and specificity of prediction. Previous studies have determined that the combination of B7-H3 and B7-H4 may be used as a novel prognostic marker for esophageal cancer (29), and that T lymphocytes plus enoblituzumab (B7-H3 antibody) can inhibit tumor growth in renal and bladder carcinoma xenografts (30). Furthermore, the B7-H2 antibody JTX-2011 has shown success in the phase 1 ICONIC clinical trial (NCT02904226) (31).…”

Section: Discussionmentioning

confidence: 99%

High expression of B7‑H2 or B7‑H3 is associated with poor prognosis in hepatocellular carcinoma

Zheng

Liao

et al. 2019

Mol Med Report

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B7 family members have been associated with the signaling transduction pathways underlying tumor immune evasion in hepatocellular carcinoma. In the present study, associations between the clinical characteristics of patients with hepatocellular carcinoma (HCC) and the expression of B7-H2 and B7-H3 were analyzed. A total of 63 formalin-fixed and paraffin-embedded HCC tissues were collected to be used as a tissue microarray. Following this, the association between B7-H2/B7-H3 and the prognosis of patients with HCC was analyzed using Pearson's χ 2 test, the Kaplan-Meier method and receiver operating characteristic curve analysis. The results demonstrated that the expression of B7-H2 was significantly associated with recurrence (within 1 year) in patients with HCC (P<0.01), and that the expression of B7-H3 was associated with recurrence (within 1 year), metastasis and 2-year overall survival rate in patients with HCC (P<0.01, P=0.036 and P=0.016, respectively). In addition, the combined expression of B7-H2 and B7-H3 was associated with prognostic factors, including recurrence (within 1 year) and survival rate (within 2 years), in patients with HCC. In particular, an increased area under the curve was achieved when the combined expression of B7-H2 and B7-H3 was considered, compared with that for α-fetoprotein. Taken together, these results indicated that B7-H2- and/or B7-H3-positive expression indicates a poor clinical outcome for patients, and the combination of B7-H2 and B7-H3 may be a preferential prognostic biomarker in patients with HCC.

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Section: Discussionmentioning

confidence: 99%

High expression of B7‑H2 or B7‑H3 is associated with poor prognosis in hepatocellular carcinoma

Zheng

Liao

et al. 2019

Mol Med Report

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“…In a previous study 13 , we reported the negative roles of B7-H4 in the proliferation, apoptosis, migration and invasiveness of cervical cancer cells as well as the diagnostic value of serum B7-H4. In addition, an increasing number of reports has suggested that B7-H3 may exert effects that are similar to those of B7-H4 8 , 20 , which prompted us to perform this study. Many studies have reported that P16 serves as a useful additional marker for the interpretation of problematic TCT and that its assessment reduces uncertainty during the evaluation of suspicious biopsies of the uterine cervix in patients with CIN and cervical cancer 21 - 24 .…”

Section: Discussionmentioning

confidence: 99%

Roles of B7-H3 in Cervical Cancer and Its Prognostic Value

Han¹,

Shi²,

Lü³

et al. 2018

J. Cancer

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B7-H3, which has been reported to be a co-regulatory ligand of the B7 family, can suppress T cell-mediated immunity and has also been reported to be expressed in many malignancies. In this study, we found that B7-H3 was primarily expressed in the cytoplasm of cervical cancer cells and was associated with deep stromal invasion (P=0.0013). The disease-free survival data showed that cervical cancer patients whose tumours were positive for B7-H3 expression had higher mortality rates compared with patients whose tumours lacked B7-H3 expression (P=0.0317), representing an advantage over P16 (P=0.3486). In contrast, the level of serum B7-H3 was low in cases of cervical intraepithelial neoplasia and cervical cancer. The silencing of B7-H3 in the SiHa, CaSki and H8 cell lines inhibited cell proliferation and enhanced apoptosis, while the over-expression of B7-H3 in HeLa cells showed inverse changes. These changes were partially due to the regulation of cell cycle- and apoptosis-related proteins, such as E2F, P21, P16, PARP-1, Caspase-8, Bax, Bcl-2 and Bcl-xl. The results of in vivo experiments revealed that the knockdown of B7-H3 in tumour cells suppressed SiHa cell growth in nude mice. Overall, B7-H3 is involved in the development and progression of cervical intraepithelial neoplasia and cervical cancer through its effects on the cell cycle and apoptosis, which are mediated via the E7/Rb pathway. B7-H3 also has the potential to be a useful prognostic marker for patients with cervical cancer.

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“…B7-H4 is frequently deregulated in human cancers including breast cancer 7 , gastric cancer 8 , gallbladder carcinoma 14 , and esophageal cancer 15 . In this study, we showed that B7-H4 expression was raised in bladder cancer cells relative to normal human urothelial cells, which was consistent with clinical data that showed an upregulation of B7-H4 in UCC 10 .…”

Section: Discussionmentioning

confidence: 99%

B7-Homolog 4 Promotes Epithelial‐Mesenchymal Transition and Invasion of Bladder Cancer Cells via Activation of Nuclear Factor-κB

Wang

et al. 2018

oncol res

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B7-homolog 4 (B7-H4), a member of the B7 family of costimulatory molecules, has been reported to be upregulated in urothelial cell carcinoma. This study was conducted to explore the biological role of B7-H4 in the aggressiveness of bladder cancer and the associated molecular mechanism. We found that the mRNA and protein levels of B7-H4 were significantly greater in bladder cancer cell lines than in SV-HUC-1 (normal human urothelial cells). Overexpression of B7-H4 significantly promoted bladder cancer cell migration and invasion, whereas knockdown of B7-H4 exerted an opposite effect. However, the growth of bladder cancer cells was not altered by B7-H4 overexpression or knockdown. Overexpression of B7-H4 promoted epithelial-mesenchymal transition (EMT), as evidenced by decreased E-cadherin and increased vimentin expression. The EMT inducers Twist1 and Snail were upregulated by B7-H4 overexpression and downregulated by B7-H4 silencing. Mechanistically, overexpression of B7-H4 induced the activation of NF-κB signaling. Pharmacological inhibition of NF-κB partially prevented B7-H4-mediated bladder cancer cell invasion. Taken together, B7-H4/NF-κB signaling is involved in the EMT and invasion of bladder cancer cells and represents a new candidate target for the treatment of bladder cancer.

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Assessment of combined expression of B7-H3 and B7-H4 as prognostic marker in esophageal cancer patients

Cited by 17 publications

References 25 publications

High expression of B7‑H2 or B7‑H3 is associated with poor prognosis in hepatocellular carcinoma

High expression of B7‑H2 or B7‑H3 is associated with poor prognosis in hepatocellular carcinoma

Roles of B7-H3 in Cervical Cancer and Its Prognostic Value

B7-Homolog 4 Promotes Epithelial‐Mesenchymal Transition and Invasion of Bladder Cancer Cells via Activation of Nuclear Factor-κB

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