CO 2 storage in fractured reservoirs may lead to fast CO 2 flow through interconnected fracture networks; but the role of isolated fractures on brine-CO 2 multiphase flow systems remains unclear. We present the results of a brine-CO 2 flow-through experiment in which we assess the change in transport properties of a synthetic sandstone plug (a surrogate of a saline siliciclastic CO 2 reservoir) containing non-connected fractures aligned 45 � from its axis. The test was performed at 40 MPa of constant hydrostatic confining pressure and ~11 MPa of pore pressure, at room temperature (~19.5 � C), using pure liquid-CO 2 and 35 g L À 1 NaCl salt solution. The injected CO 2-brine volume fraction was increased from 0 to 1 in 0.2 units-steps (drainage). Upon achievement of the maximum CO 2 saturation (S CO2 ~0.6), the plug was flushed-back with the original brine (imbibition). During the test, we monitored simultaneously pore pressure, temperature, axial and radial strains, and bulk electrical resistivity. The fractured sample showed lower values of cross-and end-points in the relative permeability curves to CO 2 compared to non-fractured samples, from comparable experiments performed at similar pressure and brine salinity conditions, but different temperature. Our results suggest that a non-connected fracture network affects the mobility of the individual phases, favouring the trapping of CO 2 in the porous medium and improving the storage efficiency of the reservoir. These evidences show the need of a better understanding of fracture connectivity prior to discard fractured reservoirs as unsuitable geological formations for CO 2 storage.