Assessment of clinicopathological and prognostic relevance of BMI‐1 in patients with colorectal cancer: A meta‐analysis

Abstract

B‐cell‐specific Moloney leukemia virus insertion site 1 (BMI‐1) is one of the stemness markers. The prognostic and clinicopathological effects of BMI‐1 expression in colorectal cancer (CRC) have been in dispute with different studies. Eligible studies were retrieved from international databases up to December 2019. Studies with a relationship between the clinicopathological and prognostic value of CRC patients with BMI‐1 expression were selected. The correlations in the random‐effect model were evaluated using the hazard ratios, odds ratio, and 95% confidence intervals (CIs). A total of nine studies comprising Asian cases (seven studies) and European cases (two studies) covering 1,294 samples of CRC were included for this meta‐analysis. The analysis suggested that in Asian cases, increased expression of BMI‐1 was associated with poor overall survival (OS) and death‐free survival, whereas in European populations, high expression of BMI‐1 was associated with better OS. Also, overexpression of BMI‐1 in the Asian population was associated with the tumor size, distant metastasis, and patient's gender and age. Results suggested that high expression of BMI‐1 can be involved in the progression and invasion of CRC, and so its inhibitor‐based therapies could be used to prevent the progression of CRC.

The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies

“…Cancer cells have the characteristics of invasion into surrounding tissues and metastasis to distant tissues, and they continue to grow in these organs, destroying the function of the organs, and finally causing the death of the patient. The expression of Bmi-1 is closely related to tumor migration and invasion [ 93 , 95 , 106 , 107 , 108 , 109 ]. It has been reported that down-regulation of Bmi-1 reduces the migration and invasion of endometrial cancer cells in vivo and in vitro, by increasing the expression levels of E-cadherin and keratin, and down-regulating N-Cadherin, vimentin, and SLUG [ 106 ].…”

Roles of BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma

“… 64 Another meta-analysis also suggested that high BMI1 expression is associated with lower overall survival rates in patients with colorectal cancer in Asia and is associated with higher overall survival rates in European populations. 65 …”