Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: Rationale and design of the Heinz Nixdorf RECALL Study

Schmermund, Axel; Möhlenkamp, Stefan; Stang, Andreas; Grönemeyer, Dietrich; Seibel, Rainer; Hirche, H.; Mann, Klaus; Siffert, Winfried; Lauterbach, Karl W.; Siegrist, Johannes; Jöckel, Karl‐Heinz; Erbel, Raimund

doi:10.1067/mhj.2002.123579

Cited by 522 publications

(437 citation statements)

References 43 publications

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“…21 Participants were randomly selected from mandatory city registries in Bochum, Essen, and Mülheim, Germany, and invited to participate in the study. A total of 4814 subjects aged 45 to 75 years were included between December 2000 and August 2003.…”

Section: Study Populationmentioning

confidence: 99%

Subclinical Coronary Atherosclerosis Predicts Cardiovascular Risk in Different Stages of Hypertension

Erbel¹,

Lehmann²,

Möhlenkamp³

et al. 2012

Hypertension

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Abstract-Prehypertension is a frequent condition and has been demonstrated to increase cardiovascular risk. However, the association with coronary atherosclerosis as part of target organ damage is not well understood. We investigated the cross-sectional relationship and longitudinal outcome between blood pressure categories and coronary artery calcification (CAC), quantified by electron beam computed tomography, in 4181 participants from the population-based Heinz Nixdorf Recall Study cohort. At baseline, we observed a continuous increase in calcium scores with increasing blood pressure categories. During a median follow-up period of 7.18 years, 115 primary end points (2.8%; fatal and nonfatal myocardial infarction) and 152 secondary end points (3.6%; stroke and coronary revascularization) occurred. We observed a continuous increase in age-and risk factor-adjusted secondary endpoints (hazard ratios [95% CI]) with increasing blood pressure categories (referent: normotension) in men: prehypertension, 1.80 (0.53-6.13); stage 1 hypertension, 2.27 (0.66 -7.81); and stage 2 hypertension, 4.10 (1.27-13.24) and in women: prehypertension, 1.13 (0.34 -3.74); stage 1 hypertension, 2.14 (0.67-6.85); and stage 2 hypertension, 3.33 (1.24 -8.90), respectively, but not in primary endpoints. Cumulative event rates were determined by blood pressure categories and the CAC. In prehypertension, the adjusted hazard ratios for all of the events were, for CAC 1 to 99, Pϭ0.13); 100 to 399, Pϭ0.03); and Ն400, Pϭ0.0002). Risk of myocardial infarction and stroke in hypertension but also in prehypertension depends on the degree of CAC. This marker of target-organ damage might be included, when lifestyle modification and pharmacotherapeutic effects in prehypertensive individuals are tested to avoid exposure to risk and increase benefit.

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Section: Study Populationmentioning

confidence: 99%

Subclinical Coronary Atherosclerosis Predicts Cardiovascular Risk in Different Stages of Hypertension

Erbel¹,

Lehmann²,

Möhlenkamp³

et al. 2012

Hypertension

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“…Best estimate diagnoses were assigned by at least 2 experienced psychiatrists/ psychologists. The controls were drawn from 3 population-based epidemiological studies: (A) PopGen 12 (n= 490), (B) KORA 13 (n= 488), and (C) the Heinz Nixdorf Recall (HNR, n= 383) study 14 (Risk Factors, Evaluation of Coronary Calcification, and Lifestyle). The recruitment areas for PopGen, KORA, and HNR were located in:…”

Section: Sample Ascertainment and Selection For The Gwas Samplementioning

confidence: 99%

Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe

Rietschel¹,

Mattheisen²,

Degenhardt³

et al. 2011

Mol Psychiatry

108

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“…1). Details of the design of the HNR have been published elsewhere [26]. In brief, study participants (n = 4814 women and men aged 45-75 years) were randomly selected from population registries and enrolled between 2000 and 2003.…”

Section: Study Populationmentioning

confidence: 99%

Residential Surrounding Greenness, Self-Rated Health and Interrelations with Aspects of Neighborhood Environment and Social Relations

et al. 2017

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Previous research suggests that green environments positively influence health. Several underlying mechanisms have been discussed; one of them is facilitation of social interaction. Further, greener neighborhoods may appear more aesthetic, contributing to satisfaction and well-being. Aim of this study was to analyze the association of residential surrounding greenness with self-rated health, using data from 4480 women and men aged 45-75 years that participated in the German population-based Heinz Nixdorf Recall study. We further aimed to explore the relationships of greenness and self-rated health with the neighborhood environment and social relations. Surrounding greenness was measured using the Normalized Difference Vegetation Index (NDVI) within 100 m around participants' residence. As a result, we found that with higher greenness, poor self-rated health decreased (adjusted OR 0.90, 95% CI 0.82-0.98; per 0.1 increase in NDVI), while neighborhood satisfaction (1.41, 1.23-1.61) and neighborhood social capital (1.22, 1.12-1.32) increased. Further, we observed inverse associations of neighborhood satisfaction (0.70, 0.52-0.94), perceived safety (0.36, 0.22-0.60), social satisfaction (0.43, 0.31-0.58), and neighborhood social capital (0.53, 0.44-0.64) with poor self-rated health. These results underline the importance of incorporating green elements into neighborhoods for health-promoting urban development strategies.

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Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: Rationale and design of the Heinz Nixdorf RECALL Study

Cited by 522 publications

References 43 publications

Subclinical Coronary Atherosclerosis Predicts Cardiovascular Risk in Different Stages of Hypertension

Subclinical Coronary Atherosclerosis Predicts Cardiovascular Risk in Different Stages of Hypertension

Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe

Residential Surrounding Greenness, Self-Rated Health and Interrelations with Aspects of Neighborhood Environment and Social Relations

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