Assessment of clinical symptoms in household contacts of confirmed pertussis cases

Domı́nguez, Àngela; Soldevila, Núria; Cenoz, Manuel García; Ferrús, Glòria; Sala-Farré, Maria R.; Álvarez, Jaime; Carol, Mónica; Barrabeig, Irene; Camps, Neus; Coronas, Lorena; Muñoz-Almagro, Carmen; Godoy, Pere; Alsedà, Miquel; Arias-Varela, César; Carmona, Glòria; Ferràs, Joaquim; Jané, Mireia; Minguell, Sofía; Rodríguez, Raquel; Sala-Farré, Maria-Rosa; Torrá, Roser; Plans, Pedro; Crespo, Inma; Toledo, Diana; Solano, Rubén; Caylà, Joan A.; Lafuente, Sarah; Rius, Cristina; Burgui, Rosana; Castilla, Jesús; Valero-Rello, Ana; Jordán, Iolanda

doi:10.1016/j.jinf.2017.08.008

Cited by 5 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Delay in treatment increases the risk of transmission and further fuels the large-scale outbreaks (Goodenough et al, 2016; Kenyon et al, 2014; Skoff et al, 2012; Winter et al, 2014). In light of the changing epidemiology, and the risk for greater spread with delayed diagnosis, clinical characteristics continue to be a relevant, if frequently ignored, diagnostic criteria for clinicians in the identification of pertussis, especially among adults and vaccinated individuals (Domínguez et al, 2017; Goodenough et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that a cough length of 14 or more days is the most sensitive of the clinical characteristics, although cough attributes (e.g. paroxysms, post-tussive vomiting) have higher specificity (Domínguez et al, 2017; Ebell et al, 2017; Jõgi et al, 2018; Moore et al, 2017). The shifting age epidemiology of pertussis cases, with longer time to treatment (Goodenough et al, 2016), makes it less likely that cases will be laboratory positive, and requires broader utilization of the clinical case definition, thereby improving reporting of probable pertussis cases to better characterize population-level susceptibility.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating the role of cough duration in the pertussis case definition among Michigan cases, 2000–2010

Knapp

Wilson

Murray

et al. 2019

Preventive Medicine Reports

View full text Add to dashboard Cite

Impressive reductions in pertussis have been achieved in the U.S. during the 20th century through childhood vaccination. Over the past two decades, increasing pertussis incidence has highlighted the need for accurate and timely reporting of cases to improve prevention and control efforts. We assessed components of the pertussis case definition, comparing use of clinical characteristics and laboratory results and their effects on internal validity, including an examination of the 2014 infant case definition. All reported pertussis cases in Michigan during 2000–2010 with data on cough length ( N = 3310) were analyzed using multivariate statistics to internally validate reported cases, and calculate odds of meeting the clinical case definition, including a cough of at least 14 days. Cough duration of reported cases averaged 32 days and was longer with greater time interval between cough onset and initial presentation to a physician. Only about half of reported cases had positive laboratory results. Among cases seeking medical evaluation prior to meeting the cough duration required to fulfill the clinical case definition, the presence of positive lab results doubled the odds that the cough duration was not met compared to cases without a positive lab test. Clinical characteristics of pertussis are frequently ignored in applying the case classification. Relying solely on laboratory confirmation and disregarding clinical characteristics results in undiagnosed pertussis cases among those who are vaccinated, among adults, and among anyone who delays seeking care. This may prevent use of appropriate prevention and prophylaxis in contacts.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluating the role of cough duration in the pertussis case definition among Michigan cases, 2000–2010

Knapp

Wilson

Murray

et al. 2019

Preventive Medicine Reports

View full text Add to dashboard Cite

show abstract

“…Influenza virus is known to cause severe disease in pregnant women and its effects extend to influence both timing of delivery and fetal growth (105). Conversely, pertussis in adults is relatively mild (106). Post-vaccine licensure studies will define whether RSV vaccines belong to the first or the second group.…”

Section: Benefits For Pregnant Women From Maternal Immunizationmentioning

confidence: 99%

Prevention of Pediatric Respiratory Syncytial Virus Lower Respiratory Tract Illness: Perspectives for the Next Decade

Aranda

Polack

2019

Front. Immunol.

View full text Add to dashboard Cite

The landscape of infant bronchiolitis and viral pneumonia may be altered by preventive interventions against respiratory syncytial virus under evaluation today. Pediatric wards in 2018 in developing countries may differ from those attended by future generation pediatricians who may not witness the packed emergency rooms, lack of available beds, or emergency situations that all physicians caring for children with RSV experience every year. In this review, we describe and discuss different prevention strategies under evaluation to protect pediatric patients. Then, we outline a number of potential challenges, benefits, and concerns that may result from successful interventions after licensure.

show abstract

“…Studies have shown that a cough duration of 14 or more days is the most sensitive of the clinical characteristics, although cough attributes (e.g. paroxysms, whooping, post-tussive vomiting) may increase specificity of clinical diagnostic criteria [10][11][12][13]. In fact, the hallmark of almost all clinical case definitions for surveillance is a cough lasting a minimum of two weeks [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A data driven clinical algorithm for differential diagnosis of pertussis and other respiratory infections in infants

et al. 2020

View full text Add to dashboard Cite

Background Clinical criteria for pertussis diagnosis and clinical case definitions for surveillance are based on a cough lasting two or more weeks. As several pertussis cases seek care earlier, a clinical tool independent of cough duration may support earlier recognition. We developed a data-driven algorithm aimed at predicting a laboratory confirmed pertussis. Methods We enrolled children <12 months of age presenting with apnoea, paroxistic cough, whooping, or post-tussive vomiting, irrespective of the duration of cough. Patients underwent a RT-PCR test for pertussis and other viruses. Through a logistic regression model, we identified symptoms associated with laboratory confirmed pertussis. We then developed a predictive decision tree through Quinlan's C4.5 algorithm to predict laboratory confirmed pertussis. Results We enrolled 543 children, of which 160 had a positive RT-PCR for pertussis. A suspicion of pertussis by a physician (aOR 5.44) or a blood count showing leukocytosis and lymphocytosis (aOR 4.48) were highly predictive of lab confirmed pertussis. An algorithm including a suspicion of pertussis by a physician, whooping, cyanosis and absence of fever was accurate (79.9%) and specific (94.0%) and had high positive and negative predictive values (PPV 76.3% NPV 80.7%). Conclusions An algorithm based on clinical symptoms, not including the duration of cough, is accurate and has high predictive values for lab confirmed pertussis. Such a tool may be useful in low

show abstract

Assessment of clinical symptoms in household contacts of confirmed pertussis cases

Cited by 5 publications

References 28 publications

Evaluating the role of cough duration in the pertussis case definition among Michigan cases, 2000–2010

Evaluating the role of cough duration in the pertussis case definition among Michigan cases, 2000–2010

Prevention of Pediatric Respiratory Syncytial Virus Lower Respiratory Tract Illness: Perspectives for the Next Decade

A data driven clinical algorithm for differential diagnosis of pertussis and other respiratory infections in infants

Contact Info

Product

Resources

About