Assessment of clinical efficacy of locally delivered 0.2% Thymoquinone gel in the treatment of periodontitis

Abstract

Significant changes in clinical and biochemical parameters were achieved in the current study. Hence, it is concluded that intracrevicular application of 0.2% Thymoquinone gel could be a beneficial adjunct to SRP in treating chronic periodontitis.

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

“…Administration of TQ can occur through several routes, including systemic intraperitoneal, intravenous, oral subacute and sub-chronic administration, besides the localized drug delivery of TQ [ 6 , 60 , 61 ]. In the current investigation the reviewed in vivo studies reported the local periodontal application of 0.1–0.2% TQ gel [ 62 , 63 , 64 ] and similarly in the form of fabricated periodontal chips containing 2.5 mg of TQ [ 65 ]. One animal investigation reported systemic TQ administration by gastric feeding, at a rate of 10 mg/kg/d [ 66 ].…”

“…In vitro studies on TQ or NS extract effects on periodontal diseases and bacteria administered solutions of 2% NS extract [ 63 ] and 0.01–10% concentrations of TQ [ 67 , 68 ]. All tested concentrations and routes of drug delivery showed significant periodontal health-favoring outcomes in terms of clinical periodontal parameters as plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment levels (CAL) [ 62 , 65 , 66 ], as well as molecular parameters as gingival crevicular fluid alkaline phosphatase levels (GCF-ALP) [ 66 ] and cytokine/chemokine levels [ 63 ]. Microbiological and histological parameters similarly showed significant improvements as observed in biofilm formation and inflammatory cell infiltration (ICI) [ 66 , 67 , 68 , 69 ].…”

“…One of these investigations selected 20 patients with 40 test sites and divided them into two groups. The first group was treated by scaling and root planning in addition to local application of 0.2% TQ gel, while patients of the second group were only treated by regular scaling and root planning [ 62 ]. After 6 weeks a statistically significant decrease was detected in PPD and GCF-ALP levels besides a rise in periodontal attachment levels in the TQ group in contrast to the regular periodontal therapy patients.…”

Effect of thymoquinone on Fusobacterium nucleatum‑associated biofilm and inflammation

“…Dental plaque is more complex and diverse among individuals and under in vivo conditions. Although a suppressive effect of TQ on alveolar bone loss and dental plaque accumulation has been demonstrated in a rat periodontitis model (22) and clinical study (38), respectively, these studies did not monitor microbiome alterations in saliva or dental plaque. Animal and clinical studies that focus on FN, a keystone periodontal pathogen, will provide new insights into the mechanisms for prophylactic and therapeutic effects of TQ on periodontal disease.…”

Fast and Ecological Liquid-Liquid Separation Method for Preparing Quinones Enriched Extract from Nigella sativa Oil

“…7 In previous clinical studies, TQ showed antiepileptic action in children and its intracrevicular application has been found to be beneficial in treating chronic periodontitis. 8,9 The reduced form of TQ, thymohydroquinone (THQ), is also considered as perspective biological active compound with antibacterial, antifungal, anti-inflammatory, antioxidative, and antitumor effects. 10,11 The inhibitory activity for acetylcholinesterase was also observed in this substance.…”