Assessment of Clinical, Biochemical, and Hormonal Profile of Lean Versus Overweight Polycystic Ovarian Syndrome Patients

Abstract

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder having escalation in its prevalence. This study was planned to understand the clinical, biochemical, and hormonal profile of lean versus overweight patients diagnosed newly with PCOS. Materials and Methods: A cross-sectional study was conducted for 1 year in the Department of Endocrinology of a tertiary care hospital. A total of 50 female patients newly diagnosed to have PCOS by the Rotterdam criteria 2003 were enrolled for the study. Assessment of clinical characteristics, biochemical, and hormonal profile was done. Results: Fasting serum insulin levels and homeostasis model assessment-insulin resistance signifying insulin resistance were higher in overweight compared to the lean PCOS. Insulin resistance was present in 50% of lean PCOS and 82% of overweight PCOS. Glucose abnormalities were noted in 13.7% of lean PCOS and 32.2% of overweight PCOS. Conclusion: Obese women with PCOS have a higher risk of increased obesity, impaired glucose tolerance, and insulin resistance as compared to lean PCOS women.

Evaluation of some hematological and biochemical parameters for women with polycystic ovary syndrome in Wasit Governorate

“…Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies diseases that affect early reproductive age in females, the first description of PCOS in 1935 by Stein and Leventhal. The diagnose is achieved by three different criteria that were used in this field and was developed by the National Institutes of Health (NIH) in 1990, Rotterdam Criteria (ROT) in 2003, Androgen Excess and PCOS Association (AE-PCOS) criteria in 2006 (1) The prevalence of PCOS is depended on the method of diagnosis, Word Health Organizations (WHO) estimate the prevalence of PCOS worldwide is 2% to 26% (1,2), with a high prevalence in obese patients at approximate 73%, the type of 8Iabdominal wall (3) The main pathophysiological characteristic of PCOS is androgen excess with a prevalence of 60-80% (4), the biochemical hyperandrogenism includes an increase in total testosterone, free testosterone, dehydroepiandrosterone (DHEA), the dehydroepiandrosterone sulfate (DHEA-S) and androstenedione (4 (. A dysfunctional interaction of behavioral, environmental, and genetic factors causes PCOS.…”