Assessment of clinical and biochemical profile of prediabetic subject in Bangladesh, attending in BIRDEM and results of intervention by lifestyle modification, metformin, and DPP4 inhibitor

Barua, Milton; Pathan, Faruque; Nabi, Masud Un; Kabir, M A

doi:10.1016/j.dsx.2019.03.019

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Data from 123 subjects with IFG, IGT or both showed that intervention with ILI, ILI + metformin or ILI + DPP4 inhibitor reduced weight, fasting and post-load glycaemia and triglycerides. 82 An observational study showed that 12 weeks of metformin reduced FPG to below the ADA diagnostic cut-off of 5.7 mmol/L in 43% of subjects with non-diabetic hyperglycaemia based on measurement of FPG or HbA1c. 18…”

Section: Other Observational Datamentioning

confidence: 99%

Metformin for diabetes prevention: update of the evidence base

Hostalek

Campbell

2021

Current Medical Research and Opinion

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Section: Other Observational Datamentioning

confidence: 99%

Metformin for diabetes prevention: update of the evidence base

Hostalek

Campbell

2021

Current Medical Research and Opinion

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“…We would also suggest that even non-diabetic staff with the Metabolic Syndrome be offered treatment with Metformin. 22,23 This drug improves insulin resistance which is a known association with eosinopenia, a major predictor of risk in COVID-19, 9 and has been show to protect against post-infective pulmonary fibrosis. 24…”

Section: Uk Experiencementioning

confidence: 99%

Occupational risk prevention, education and support in black, Asian and ethnic minority health worker in the COVID-19 pandemic

Morris

Elneil

Morris

et al. 2020

Journal of Patient Safety and Risk Management

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The onset of the COVID-19 in the UK has resulted in an inordinate amount of deaths affecting Black, Asian and Ethnic Minority (BAME) healthcare workers. The occupational risk to this group is thought to be a contributory factor, but other factors include race, genetics, medical co-morbidities, socio-economic status, and access to personal protection equipment. Why COVID-19 appears to be more deadly in BAME members remains unknown, but the UK government is investigating this now. It does appear that certain factors may worsen the disease process in BAME members, but which ones are pertinent to prevention remain to be determined, until a vaccine is available. Thus, the onus should rest on risk prevention, education, and support for all. Some of the safety strategies that may be instituted to help guide those in the workplace include education, treating potential therapeutic targets and ensuring protection in the working environment. The consideration of a compensation scheme, for families of healthcare workers that have suffered because of COVID-19, would go some way to support the recovery process.

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“…No conclusions have been drawn based on the limited studies. 18 , 19 We have previously shown that, similar to exercise, DPP-4 inhibition can significantly reduce the risk of T2DM in mice with HINS by improving pancreatic islet function. 20 To provide further evidence for using DPP-4 inhibitors as a protective drug, investigation into the hepatic role of DPP-4 inhibitors in mice with HINS is required.…”

Section: Introductionmentioning

confidence: 99%

DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C_ε expression in a mouse model of hyperinsulinemia

Xiao²,

et al. 2020

J Int Med Res

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Objective Interventions for hyperinsulinemia (HINS), an early indicator of type 2 diabetes mellitus (T2DM), can significantly reduce the T2DM risk. This study aims to determine how dipeptidyl peptidase-4 (DPP-4) inhibition prevents HINS progression to T2DM through ameliorating hepatic steatosis. Methods KKay mice were used as a HINS model and they underwent exercise or received a DPP-4 inhibitor, MK0626. Hepatic steatosis was examined and liver diacylglycerol levels were determined. Human hepatic cells (LO2) were treated with MK0626 or transfected with DPP-4 siRNA. Protein kinase C ε isoform (PKCε) and DPP-4 expression and insulin receptor substrate 1 (IRS-1) phosphorylation were assessed using immunohistochemistry and western blot. Results KKay mice developed HINS spontaneously at 7 weeks of age. Similar to exercise, MK0626 ameliorated hepatic steatosis and reduced the liver triglyceride and diacylglycerol content. Both exercise and MK0626 suppressed diacylglycerol-induced PKCε expression and restored insulin signaling, which was shown by tyrosine phosphorylation of IRS-1, in the livers of KKay mice. Additionally, silencing DPP-4 or MK0626 treatment decreased PKCε expression in LO2 cells. Conclusions Our data demonstrate that DPP-4 inhibition resembles exercise and effectively delays T2DM onset by suppressing hepatic PKCε expression in the HINS mouse model.

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Assessment of clinical and biochemical profile of prediabetic subject in Bangladesh, attending in BIRDEM and results of intervention by lifestyle modification, metformin, and DPP4 inhibitor

Cited by 4 publications

References 12 publications

Metformin for diabetes prevention: update of the evidence base

Metformin for diabetes prevention: update of the evidence base

Occupational risk prevention, education and support in black, Asian and ethnic minority health worker in the COVID-19 pandemic

DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C_ε expression in a mouse model of hyperinsulinemia

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Assessment of clinical and biochemical profile of prediabetic subject in Bangladesh, attending in BIRDEM and results of intervention by lifestyle modification, metformin, and DPP4 inhibitor

Cited by 4 publications

References 12 publications

Metformin for diabetes prevention: update of the evidence base

Metformin for diabetes prevention: update of the evidence base

Occupational risk prevention, education and support in black, Asian and ethnic minority health worker in the COVID-19 pandemic

DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase Cε expression in a mouse model of hyperinsulinemia

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Product

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DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C_ε expression in a mouse model of hyperinsulinemia