Assessment of chronic bronchitis and risk factors in young adults: results from BAMSE

Wang, Gang; Hallberg, Jenny; Bergström, Petra Um; Janson, Christer; Pershagen, Göran; Gruzieva, Olena; Hage, Marianne van; Georgelis, Antonios; Bergström, Anna; Kull, Inger; Lindén, Anders

doi:10.1183/13993003.02120-2020

Cited by 42 publications

(53 citation statements)

References 45 publications

(27 reference statements)

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“…Vyntus system (Vyaire Medical). 23 The same spirometry test protocol was used at all time-points. Z-scores for forced expiratory volume in the first second (FEV 1 ) and forced vital capacity (FVC) were computed for each participant, using the GLI reference equations.…”

Section: Assessment Of Lung Functionmentioning

confidence: 99%

Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood

Sdona

Ekström

Andersson

et al. 2021

Clin Experimental Allergy

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Background: Dietary antioxidants may protect the lung against oxidative damage and prevent chronic respiratory disease. We aimed to investigate fruit, vegetable and antioxidant intake (measured as total antioxidant capacity, TAC) at age 8 years in relation to asthma and lung function up to 24 years. Methods:In this study of 2506 participants from a Swedish birth cohort, diet was assessed using food frequency questionnaires. Information on asthma was collected by questionnaires, and lung function was measured by spirometry at ages 8, 16 and 24 years. Generalized estimating equations and mixed effect models were used to assess overall, age-and sex-specific associations.Results: After adjustment for confounders, a higher fruit intake at age 8 years was associated with a tendency to reduced odds of prevalent asthma (T3 vs. T1, OR 0.78; 95% CI 0.60-1.01, p-trend .083), with reduced odds of incident asthma and increased odds of remittent asthma (≥median, OR 0.76; 95% CI 0.58-0.99 and OR 1.60; 95% CI 1.05-2.42, respectively) up to 24 years. Comparable, but non-significant, odds ratios were observed in analyses of long-term fruit intake (mean intake at ages 8 and 16 years). In contrast, no association was observed with vegetable intake. A higher dietary TAC (T3 vs. T1) at 8 years was associated with reduced odds of prevalent asthma (OR 0.73; 95% CI 0.58-0.93, p-trend .010) and improved lung function development (FEV 1 -z +0.11; 95% CI 0.01-0.21, p-trend .036 and FVC-z +0.09; 95% CI −0.01-0.20, | 105 SDONA et Al.

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Section: Assessment Of Lung Functionmentioning

confidence: 99%

Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood

Sdona

Ekström

Andersson

et al. 2021

Clin Experimental Allergy

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“…Clinical examinations including blood samples and lung function tests were performed at 4, 8, 16 and 24 years of age as described previously. 16,17 The study population is described in Figure S1.…”

Section: The Bamse Projectmentioning

confidence: 99%

Prevalence and early‐life risk factors for tree nut sensitization and allergy in young adults

Bager

Tedner

Andersson

et al. 2021

Clin Experimental Allergy

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Background: Tree nut allergy may cause anaphylaxis. There are limited populationbased studies on prevalence and early-life risk factors. Methods:We evaluated the prevalence of reported symptoms and allergic sensitization to tree nuts at age 24 years in the BAMSE population-based cohort study and assessed early-life factors associated with the development of tree nut allergy.We estimated tree nut allergy prevalence, by analysing questionnaire data on tree nut ingestion and symptoms at age 12, 16 and 24 years, and IgE sensitization at age 24 years to hazelnut, walnut, pecan, cashew, pistachio, Brazil nut, almond extracts and allergen molecules Cor a 1, 9, 14 (hazelnut), Jug r 1 (walnut) and Ana o 3 (cashew).We evaluated eczema, asthma, food allergies, inherited risk of allergy and gender as potential early-life risk factors.Results: Data were available for 2215/4089 (54%) BAMSE study participants, for estimation of the prevalence of tree nut sensitization (21.2%), tree nut allergy symptoms (9.8%) and combined sensitization and symptoms (7.9%, 2.1% for storage protein sensitization and symptoms, 4.3% for any sensitization and non-mild symptoms). Sixtythree per cent of sensitized individuals (295/470) were asymptomatic, but only 76/470

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“…In a subsample of 940 and 939 participants at 8 and 16 y, respectively, blood samples were in addition analyzed for fatty acids in plasma phospholipids (as will be described). Lung function was measured by spirometry at 8, 16, and 24 y (see the Supplemental Methods ) ( 20 ). The results were analyzed as age-, height-, and gender-adjusted values of forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC) (in mL), FEV 1 /FVC (%), and by z scores using the Global Lung Initiative reference values ( 21 ).…”

Section: Methodsmentioning

confidence: 99%

Dietary intake and plasma concentrations of PUFAs in childhood and adolescence in relation to asthma and lung function up to adulthood

Ekström

Sdona

Klevebro

et al. 2022

The American Journal of Clinical Nutrition

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Background Polyunsaturated fatty acids (PUFA) may influence the risk of asthma, however long-term prospective studies including objective biomarkers of PUFA intake are lacking. Objective The objective was to investigate the role of dietary and plasma levels of n-3 and n-6 PUFA in childhood and adolescence for the development of asthma and lung function up to young adulthood. Methods The study included participants from the Swedish prospective birth cohort BAMSE. Dietary intake of PUFA was calculated from food frequency questionnaires (n = 1992) and plasma proportions of PUFA were measured in phospholipids (n = 831). We analyzed the n-3 PUFA α-linolenic acid (ALA), the sum of very long-chain (VLC) n-3 PUFA: eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid, and the n-6 PUFA linoleic acid (LA) and arachidonic acid (AA). Asthma was assessed by questionnaires at 8, 16, and 24 years and lung function was measured by spirometry at 24 years. Results A high (≥ median) self-reported dietary intake of LA at 8 years and AA at 16 years was associated with increased risk of prevalent asthma at 24 years (odds ratio (OR): 1.41, 95% confidence interval (CI): 1.10,1.82 and OR: 1.32, 95% CI: 1.02,1.70, respectively). In contrast, plasma proportions of ALA, ∑VLC n-3 PUFA and AA at 8 years, as well as LA at 16 years, were inversely associated with prevalent asthma at 24 years (e.g. OR: 0.55, 95% CI: 0.38,0.81 for ∑VLC n-3 PUFA). No consistent associations were observed with lung function. Conclusion High dietary intake of certain n-6 PUFA in childhood or adolescence may be associated with increased risk of asthma up to young adulthood, while dietary biomarkers of certain n-3 and n-6 PUFA in plasma may be associated with decreased risk. Thus, the role of diet versus altered metabolism of PUFA needs further investigation to improve dietary preventive strategies of asthma.

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Assessment of chronic bronchitis and risk factors in young adults: results from BAMSE

Cited by 42 publications

References 45 publications

Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood

Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood

Prevalence and early‐life risk factors for tree nut sensitization and allergy in young adults

Dietary intake and plasma concentrations of PUFAs in childhood and adolescence in relation to asthma and lung function up to adulthood

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