Assessment of chromosomal aberrations, micronuclei and proliferation rate index in peripheral lymphocytes from Tunisian nurses handling cytotoxic drugs

Bouraoui, S.; Brahem, A.; Tabka, F.; Mrizek, Najib; Saâd, Ali; Elghezal, Hatem

doi:10.1016/j.etap.2010.11.004

Cited by 37 publications

(32 citation statements)

References 39 publications

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“…In addition to work stress and exhaustion, the studies carried out until now reveal that the healthcare staff experience health problems such as nausea-vomiting, fatigue, exhaustion, sleepiness, decrease in blood values, diarrhoea, eye and throat irritation, menstrual irregularities, skin reactions, hair loss, headache and dizziness depending on chemotherapy drugs [4,13]. In the study ofKöşgeroğlu et al [22], however, the haemoglobin and leukocyte average values of the nurses were examined and no significant difference was found among those administering and not administering chemotherapy; it was indicated that as the number of patients having daily chemotherapy administration increased, haemoglobinvalues decreased.…”

Section: Discussionmentioning

confidence: 99%

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A Qualitative Study: Determination of the Working Conditions and Knowledge Levels of Oncology Nurses in Terms of Employee Safety

Tuna¹,

Baykal²

2017

Int J Nurs Clin Pract

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Background: The antineoplastic drugs used in cancer treatment directly have adverse effects on health of both patients receiving the treatment and oncology nurses preparing and administering the treatment. The purpose of this study is to determine the working conditions of the oncology nurses in terms of employee safety as well as their knowledge levels regarding the safe use of antineoplastic drugs. Methods: This is a qualitative study conducted with 25 oncology nurses in a phenomenological design. The data obtained were analysed by using the content analysis. Results:The results of the study were gathered under 3 main themes; employee safety (sub themes-safe use of the antineoplastic drugs, health problems, health checks, waste management), working conditions (sub themes-working and resting hours,salary) and training (sub themes-orientation, chemotherapy preparation certificate, continuous training). Conclusion:As happens all over the world, there have also been policies and standards regarding the safe use of antineoplastic drugs in Turkey; however, it is found that they remain insufficient to put into practice.

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Section: Discussionmentioning

confidence: 99%

“…Even though it is requested that the antineoplastic drugs used in cancer treatment affect only the cancer cells without harming the normal tissues, it is indicated that these drugs have many negative effects such as mutagenic, carcinogenic, and teratogenic [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A Qualitative Study: Determination of the Working Conditions and Knowledge Levels of Oncology Nurses in Terms of Employee Safety

Tuna¹,

Baykal²

2017

Int J Nurs Clin Pract

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“…Health care workers who prepare or administer hazardous drugs or who work in areas where they are used may be exposed to these agents in the air, on work surfaces, contaminated clothing, medical equipment, patient excreta, and other surfaces (80)(81)(82)(83). These workers include shipping and receiving personnel, pharmacists and pharmacy technicians, nursing personnel, and environmental services personnel (20). Workers employed in the synthesis and production of these products and staff involved in cleaning, transport, and disposal of hazardous drugs or contaminated material may all face health risks (20,36,(84)(85)(86).…”

Section: Occupational Exposure To Antineoplastic Drugsmentioning

confidence: 99%

“…Antineoplastic or cytostatic drugs are a heterogeneous group of widely used therapeutics for neoplastic and non-neoplastic diseases. However, these drugs have been proved to be also mutagens, carcinogens, and teratogens (19)(20)(21)(22)(23)(24)(25).…”

Section: Antineoplastic Drugs In Cancer Treatmentmentioning

confidence: 99%

“…According to the European Guidelines (74), any use of carcinogenic, mutagenic or teratogenic substances, including the application in health care settings, is assigned to the highest risk level (20)(21)(22)(23)75). Based on epidemiological reports, animal carcinogenicity data, and the outcomes of in vitro genotoxicity studies, several antineoplastic drugs have been classified by the International Agency for Research on Cancer (IARC) as belonging to the group of human carcinogens (Group 1), probable human carcinogens (Group 2A), or possible human carcinogens (Group 2B) (76,77).…”

Section: Occupational Exposure To Antineoplastic Drugsmentioning

confidence: 99%

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Forgotten public health impacts of cancer – an overview

Viegas

Ladeira

Veiga

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs). There are also hidden costs such as health insurance premiums and nonmedical expenses that are worth noting. This paper intends to present an overview of the generally forgotten impacts that the increasing number of cancer cases can have on the environment, workers who handle antineoplastic drugs, and health services. The knowledge available of each of the impacts will be addressed and discussed regarding the expected development. Overall, lessons learnt reflect on the impact of cancer through aspects not commonly evidenced in the literature or even considered in socio-economic analysis, in part due to the fact that these are difficult to contemplate in direct and indirect cancer costs already defined. Attention may be drawn to the need of continuous investment in prevention to reduce the negative impact on the environment, and in the health of workers who handle antineoplastic drugs for patients' treatment. KEY WORDS: costs of cancer; global burden; occupational healthGlobally, cancer is a growing public health problem. It is the second cause of death (21 %) after cardiovascular diseases (48 %), followed by respiratory diseases (12 %) in the sector of non-communicable diseases or diseases caused by non-infectious and non-transmissible medical conditions (1). Important resources are mobilised in order to improve research on new therapeutics, and ultimately devise a cure for this particular disease. Despite the increase in the effectiveness and specificity of chemotherapeutic treatments, cancer still remains one of the most harmful diseases (2-4).In 2012, worldwide incidence of cancer rose to an estimated 14 million new cases per year, with an estimated 8.2 million cancer deaths. The most common cancers diagnosed were of lung (1.8 million cases, 13 %), breast (1.7 million, 11.9 %) and colon (1.4 million, 9.7 %) (1

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Cytotoxic Drug Manipulation and Its Impact on Occupational Safety of Hospital Workers

Silva

Arezes

Schierl

et al. 2016

Advances in Intelligent Systems and Computing

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Assessment of chromosomal aberrations, micronuclei and proliferation rate index in peripheral lymphocytes from Tunisian nurses handling cytotoxic drugs

Cited by 37 publications

References 39 publications

A Qualitative Study: Determination of the Working Conditions and Knowledge Levels of Oncology Nurses in Terms of Employee Safety

A Qualitative Study: Determination of the Working Conditions and Knowledge Levels of Oncology Nurses in Terms of Employee Safety

Forgotten public health impacts of cancer – an overview

Cytotoxic Drug Manipulation and Its Impact on Occupational Safety of Hospital Workers

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