Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)

Altun, Mehmet; Yılmaz, Bilal; Orhan, İlkay Erdoğan; Çitoğlu, Gülçin Saltan

doi:10.1016/j.indcrop.2012.07.017

Cited by 60 publications

(28 citation statements)

References 31 publications

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“…P R is credible criterion for the evaluation of the antioxidant activity, as reported in studies on various polyphenolcontaining materials [8], where a statistically significant correlation between the amount of polyphenols and P R was demonstrated. Dose-depended reducing effects have been demonstrated for H. perforatum extracts and concurred with other antioxidant properties [23].…”

Section: Antioxidant Activitysupporting

confidence: 71%

Optimisation of organic solvent-free polyphenol extraction from Hypericum triquetrifolium Turra using Box–Behnken experimental design and kinetics

et al. 2015

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Hypericum triquetrifolium Turra is a plant rich in biologically functional polyphenolic phytochemicals. The efficient recovery of polyphenols from this material has not been previously investigated in depth, in terms of establishing an environmentally benign and cost-effective process that would aim at producing extracts enriched in polyphenolic compounds. The objective of the present study was the examination of the efficiency of water/ glycerol mixtures in extracting polyphenols from dried aerial parts of H. triquetrifolium Turra and its critical comparison with water. Extraction temperature and time were optimised using response surface methodology, while comparative assessment of the extraction efficiency between water/glycerol and water was carried out using kinetics. The results showed that 10 % (w/v) aqueous glycerol at 70°C provided very satisfactory extraction yield in total polyphenols (54.83 mg gallic acid equivalents per g of dry weight), which was significantly higher than that attained with water (17.3 %). Similar results were drawn for the reducing power, in concurrence with the polyphenolic concentration. Liquid chromatography-mass spectrometry analysis showed that the polyphenolic profile of water/glycerol extract was composed by polar substances, such as chlorogenic acids and quercetin glycosides.Diffusion (m 2 s -1 ) dw Dry weight (g) h Initial extraction rate (mg g -1 min -1 ) k Extraction rate constant (g mg -1 min -1 ) P R Reducing power (lmol AAE g -1 dw) R Effective particle radius (m)

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Section: Antioxidant Activitysupporting

confidence: 71%

Optimisation of organic solvent-free polyphenol extraction from Hypericum triquetrifolium Turra using Box–Behnken experimental design and kinetics

et al. 2015

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“…H. perforatum ethanolic extract may improve microglial viability by reducing amyloid-beta mediated toxicity in Alzheimer's disease [63]. Hypericumperforatum inhibits acetylcholinesterase enzyme [64] and MDA formation in the brain and increases the level of SOD, CAT, GPx. According to these findings, H. perforatum also act as an antioxidant and have the ability to bind iron ions and have scavenging action for hydroxyl radical [65].…”

Section: Hypericum Perforatummentioning

confidence: 99%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long-term and is becoming a major health problem in the 21st century. Neurons degenerated are not replaced resulting in a cognitive loss, many neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease (AD), dementia, cerebrovascular impairment, seizure disorders, head injury, parkinsonism. The common pathology of neurodegeneration includes deposition of misfolded proteins such as amyloid-β (Aβ) in Alzheimer's disease, α-synuclein in Parkinson's disease (PD), transactive response DNA-binding protein 43 (TDP-43) in dementia. Neuroprotection refers to the strategies and possible mechanisms that are able to protect the central nervous system (CNS) against neuronal injury and neurodegenerative disorders. The past decade has witnessed an intense interest in herbal plants having long-term health-promoting or medicinal qualities. Comprehensive research and discovery have demonstrated that natural products, medicinal herbs, plant extracts, and their metabolites, have great potential as the neuroprotective agent. Although the precise mechanisms of action of herbal drugs have yet to be determined, some of them have been shown to prevent formation of betaamyloid plaques, promote nerve growth, some inhibit acetylcholinesterase (AChE) enzyme and malondialdehyde (MDA) formation in brain while other exhibits antioxidant activity by increasing the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Thus the herbal plants can be a valuable source of the drug against neurodegenerative disorders which will require high-throughput screening. This review will highlight the role of herbal plants and their phytoconstituents against neurodegenerative diseases and other related disorders, focusing on their mechanism of action and therapeutic potential.

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“…F2, which was composed of Salvia miltiorrhiza Bunge, Hypericum perforatumL. and Ginkgo biloba L., had a low calculated IC 50 value (Table 5), similarly it was reported that Hypericum perforatum L. extract did not possess metal-chelating activity 32 . Thus, the metal chelating activity of F2 might thus be due to the presence of Ginkgo biloba L.or Salvia miltiorrhiza Bunge that could act in a synergistic or additive way.…”

Section: Discussionmentioning

confidence: 60%

“…The strongest AChE activity was exhibited by F2 which contained in addition to two other herbs Hypericumperforatum L. The latter was reported to be responsible for neurochemical modulation, which might be due to the presence of flavonoids, namely hyperforin and hypericin 49 . It was reported that methanolic extract of Hypericumperforatum L. did possess anticholinesterase activity 32 . The inhibitory activity of AChE with Salvia miltiorrhiza Bunge was found to be due to the presence of triterpenoids 7 .…”

Section: Discussionmentioning

confidence: 99%

Anticholinesterase and Antioxidant Effects of Traditional Herbal Medicines used in the Management of Neurodegenerative Diseases in Mauritius

Mottay¹,

Neergheen-Bhujun²

2016

Arch Med Biomed Res

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Bioactive plant constituents from traditional herbal medicines can simultaneously protect neurons against oxidative stress and act as cholinesterase inhibitors, two key factors involved in the pathogenesis of neurodegenerative diseases. This study thus aimed at investigating the antioxidant and anticholinesterase activities of five herbal medicines, including 3 polyherbal formulas (F1, F2, F4) and 2 singleherb formulas (F3 and F5), currently used in Mauritius. Antioxidant activities were determined by the reducing potential, scavenging and chelating properties while the pro-oxidant effects was characterized by the copper-phenanthroline assay. While all extracts exhibited antioxidant activity, different extent of such property was observed in each assay. F3 containing Gingko biloba L. demonstrated a higher ferric reducing antioxidant potential (1654 ± 37.8 μmol Fe (II) equivalent/g dry weight) compared to the other extracts. The elixir F2 consisting of Gingko biloba L., Hypericum perforatum L. and Salvia miltiorrhiza Bunge was a potent scavenger of hypochlorous acid and hydroxyl radical and was a strong iron (II) chelator. All extracts inhibited acetylcholinesterase enzyme in a dose-dependent manner, which correlated strongly with total phenolics (r=0.894, p<0.01) and total proanthocyanidins (r=0.937, p<0.01). These findings suggested that activities of the locally available herbal drugs used to slow the progression of neurodegenerative disorder might be partly ascribed to their antioxidant and anticholinesterase activity.

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Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)

Cited by 60 publications

References 31 publications

Optimisation of organic solvent-free polyphenol extraction from Hypericum triquetrifolium Turra using Box–Behnken experimental design and kinetics

Optimisation of organic solvent-free polyphenol extraction from Hypericum triquetrifolium Turra using Box–Behnken experimental design and kinetics

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Anticholinesterase and Antioxidant Effects of Traditional Herbal Medicines used in the Management of Neurodegenerative Diseases in Mauritius

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