Assessment of changes in the liver of pregnant female rats and their fetuses following monosodium glutamate administration

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

“…Among the important findings of the present study was the noticeable hyperplasia of bile ducts in high-dose MSG-treated mothers. This result agreed with Eid et al ( 2018 ) and Gad EL-Hak et al ( 2021 ). Hyperplasia associated with acute liver injury in which an increased number of ducts are confined to the portal tract is observed (Uchida et al 1983 ; Nakanuma and Ohta 1986 ; Popper et al 1987 ; Desmet 1987 ).…”

“…Dilatation and congestion of the hepatic sinusoids, and central and portal veins recorded in this study were similar to results obtained by Hussin and Tala’a ( 2019 ) and Gad EL-Hak et al ( 2021 ). According to Haschek et al ( 2013 ), congestion may be due to the failure of the heart, which produces changes in different organs via excessive blood in the venous system and increases blood pressure on the surrounding capillaries, which may exert undue stress in the surrounding structures.…”

“…The current study showed that the liver of mothers treated with different doses of MSG was markedly affected. The fatty degeneration and lymphocytic inflammatory infiltration observed in the liver of MSG-treated mothers were in agreement with Kumbhare et al ( 2015 ), Eid et al ( 2018 ), Othman and Jumah ( 2019 ), and Gad EL-Hak et al ( 2021 ). Kumbhare et al ( 2015 ) stated that the presence of these fat droplets represents the response of hepatocytes to the ingestion of MSG, while Sherlock and Dooley ( 1993 ) suggested that the fatty changes induced in the liver in pathological conditions may be due to an imbalance between the normal rates of lipids synthesis and utilization.…”

“…Moreover, the recorded reduction in body weight and crown-rump length of fetuses at the 19th day of gestation maternally treated with MSG were in agreement with George et al ( 2013 ), Tawfeeq and Jarjees ( 2013 ), Abu Elnaga et al ( 2019 ), and Gad EL-Hak et al ( 2021 ) in rat fetuses. This may be explained by Husarova and Ostatnikova ( 2013 ) who reported that MSG decreased the pituitary gland growth hormone level which is directly responsible for fetal growth.…”

Comments on “Assessment of changes in the liver of pregnant female rats and their fetuses following monosodium glutamate administration” by Gad El-Hak et al., http://doi.org/10.1007/s11356-021–13,557-7

“…In the article entitled “Assessment of changes in the liver of pregnant female rats and their fetuses following monosodium glutamate administration” by Gad EL-Hak et al ( 2021 ), it is reported that forced oral administration of monosodium glutamate (MSG) from day 0 to day 20 of pregnancy induced biochemical, histological, and histochemical changes in the liver of maternal and fetal rats. The authors conclude that these study results indicate the risks of human consumption of MSG in pregnancy.…”