The American Journal of Cardiology

2008

DOI: 10.1016/j.amjcard.2007.10.016

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Assessment of Changes in Non-Calcified Atherosclerotic Plaque Volume in the Left Main and Left Anterior Descending Coronary Arteries over Time by 64-Slice Computed Tomography

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Stephan Achenbach

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et al.

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Association Between Plaque Volume Changes and Cardiovascular1

Discussion1

Contrast-enhanced Coronary Cta For the Assessment Of Coronar1

Non-invasive Imaging Techniques1

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Cited by 74 publications

(40 citation statements)

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“…Our findings support a study that found that the rate of change in plaque volume did not differ significantly according to LDL cholesterol level (23). Current guidelines do not recommend CTA screening due to it's radiation hazard, or use of contrast agents due to the expense.…”

Section: Association Between Plaque Volume Changes and Cardiovascularsupporting

confidence: 81%

Serial Changes of Coronary Atherosclerotic Plaque: Assessment with 64-Slice Multi-Detector Computed Tomography

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²

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et al. 2013

J Korean Soc Radiol

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: To evaluate the progression of coronary atherosclerotic plaque during follow-up, and its association with cardiovascular risk factors. Materials and Methods: Fifty-six atherosclerotic patients with plaque were enrolled in this retrospective study. Patient's plaque was detected on repeat 64-slice multidetector CT scans with a mean interval of 25 ± 10 months changes in calcified and noncalcified plaque volumes and cardiovascular risk factors were assessed over time. Absolute and relative changes in plaque volume were compared, and the association between rapid progression and cardiovascular risk factors was determined. Results: Diameter of the stenosis, length, calcified and non-calcified lesion plaque volumes increased significantly on follow-up CT. Absolute and relative annual changes in plaque volumes were significantly greater in non-calcified plaque (median, 22.7 mm 3 , 90.4%) than in calcified plaque (median, 0.7 mm 3 , 0%). Obesity, smoking, hypertension, hypercholesterolemia, and low high-density lipoprotein were significant predictors of progression of non-calcified plaque. Progression of calcified plaque was not associated with any cardiovascular risk factors. Conclusion: Coronary plaque volume increased significantly on follow-up CT. The rate of progression is related to non-calcified plaque than to calcified plaque. Cardiovascular risk factors are independently associated with the rapid progression of non-calcified plaque volume, but not associated with the progression of calcified plaque.

“…Our findings support a study that found that the rate of change in plaque volume did not differ significantly according to LDL cholesterol level (23). Current guidelines do not recommend CTA screening due to it's radiation hazard, or use of contrast agents due to the expense.…”

Section: Association Between Plaque Volume Changes and Cardiovascularsupporting

confidence: 81%

Serial Changes of Coronary Atherosclerotic Plaque: Assessment with 64-Slice Multi-Detector Computed Tomography

¹

,

²

,

³

et al. 2013

J Korean Soc Radiol

View full text Add to dashboard Cite

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: To evaluate the progression of coronary atherosclerotic plaque during follow-up, and its association with cardiovascular risk factors. Materials and Methods: Fifty-six atherosclerotic patients with plaque were enrolled in this retrospective study. Patient's plaque was detected on repeat 64-slice multidetector CT scans with a mean interval of 25 ± 10 months changes in calcified and noncalcified plaque volumes and cardiovascular risk factors were assessed over time. Absolute and relative changes in plaque volume were compared, and the association between rapid progression and cardiovascular risk factors was determined. Results: Diameter of the stenosis, length, calcified and non-calcified lesion plaque volumes increased significantly on follow-up CT. Absolute and relative annual changes in plaque volumes were significantly greater in non-calcified plaque (median, 22.7 mm 3 , 90.4%) than in calcified plaque (median, 0.7 mm 3 , 0%). Obesity, smoking, hypertension, hypercholesterolemia, and low high-density lipoprotein were significant predictors of progression of non-calcified plaque. Progression of calcified plaque was not associated with any cardiovascular risk factors. Conclusion: Coronary plaque volume increased significantly on follow-up CT. The rate of progression is related to non-calcified plaque than to calcified plaque. Cardiovascular risk factors are independently associated with the rapid progression of non-calcified plaque volume, but not associated with the progression of calcified plaque.

“…Furthermore, Fassa et al [28] have revealed that revascularization can be safely deferred for patients with angiographically indeterminate lesions of the LMCA with a minimum lumen area C7.5 mm 2 on IVUS. On the other hand, quantification of plaque volume to document the progression of coronary atherosclerosis is also possible by repeated MSCT examinations [29]. The clinical implication of these findings should be assessed by future studies because even nonsignificant plaques in LMCA and proximal LAD revealed by MSCT have been associated with adverse outcome [6].…”

Section: Discussionmentioning

confidence: 98%

Prevalence of left main coronary artery disease among patients referred to multislice computed tomography coronary examinations

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et al. 2008

Int J Cardiovasc Imaging

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We have evaluated the prevalence of left main coronary artery disease (LMCAD) among patients referred to multislice computed tomography (MSCT) coronary angiography examinations. The study Group comprised of 1,000 consecutive patients (750 male and 250 female; mean age 53+/-12 years) who underwent successful 64-slice MSCT examinations. Left main coronary artery (LMCA) was classified into three Groups: normal LMCA; nonsignificant LMCAD with coronary plaques resulting in obstructions 50%. We have found that 24 patients (2.4%) had significant LMCAD. Additional 200 patients (20%) had nonsignificant LMCAD. Univariate analysis revealed that LMCAD was associated with age, male gender, diabetes, hypertension, hyperlipidemia, typical symptoms, history of previous myocardial infarction and previous percutaneous coronary intervention. Only age and male gender were found as independent predictors for LMCAD in multivariate analysis (P < 0.001 and P = 0.001, respectively,). Angiographic follow-up was avaliable for the 24 patients with significant LMCAD, and conventional coronary angiography confirmed the presence of significant LMCAD in all of these patients. Significant LMCAD was found in 2.4% of the 1,000 patients referred to 64-slice MSCT examinations. Age and male gender were the independent predictors for LMCAD.

“…19 -22 In a study of 50 patients followed over a mean period of 17 months, the mean annualized plaque volume of noncalcified plaques in the left main or proximal left anterior descending artery increased by 22% (95% CI, 14.7% to 29.7%) per year. 20 Interestingly, statin therapy had no significant influence on the mean annualized progression of noncalcified plaque volume (Pϭ0.6). In another study of 69 patients, using a semiquantitative score based on the presence of noncalcified plaque in 1-mm cross-sections of the left main coronary artery and proximal 40-mm segments of the other coronary vessels, demonstrated a significant relative increase of 41.9% (Pϭ0.04) between baseline and 2-year repeat CTA scan.…”

Section: Contrast-enhanced Coronary Cta For the Assessment Of Coronarmentioning

confidence: 99%

Computed Tomography Coronary Plaque Imaging as a Secondary End Point for Randomized Pharmaceutical Trials

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2010

Circ: Cardiovascular Imaging

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