Assessment of Changes in Lipid Profile of Pregnant Women during Periods of Gestation and Post Partum in Chotanagpur – A Descriptive Study

Abstract

Introduction:There is a change in energy usage along with accumulation of fat during different trimesters of pregnancy. Altered hormonal status of the body in pregnancy leads to changes in lipid profile which is accompanied by changes in maternal lipoprotein required for the growth and development of the foetus. High lipid profile has adverse effects leading to atherosclerosis which is found to be due to raised cholesterol, triglyceride level. Current study aimed to analyze the levels of total cholesterol (TC), low-density lipoprotein (LDL), highdensity lipoprotein (HDL), and triglycerides (TGs) during pregnancy and their changes during post partum period. Material and Methods:The study was performed on 110 pregnant women after taking an informed consent from patients to get enrolled in the study. Lipid profiles were assessed using standard procedures. Results: Among the four analytes triglycerides shows the largest increase and HDL-C the smallest. All the values are raised during pregnancy except HDL-C which is stabilized during the second trimester. Conclusion:The clinically non-significant elevated lipid profile in the pregnancy period and decline in the postpartum period are physiological.

The effect of gestational periods on fasting lipid profile, plasma glucose and chromium levels of apparently healthy pregnant women in Port-Harcourt, Nigeria

“…This report agrees with that of Blessing et al which noted an increase in triglyceride levels in the second and third trimesters of pregnancy. 12 Also, the report from this study is in agreement with that of Kumari et al 16 This elevated plasma triglyceride level during pregnancy is necessary as an energy store to take care of the metabolic needs of the mother and fetus particularly towards late gestation, and functions as a source of milk formation prior to parturition. 17 At the later stage of pregnancy, fat depots are rapidly broken down, which is essential in developing the fetus.…”

“…19 However, the report obtained from this study disagrees with that of Kumari et al which stated an HDL increase in the first trimester, a decrease in the second trimester, and then an increase in the third trimester. 16 Kumari et al stated that the initial increase in HDL in the first trimester is estrogen-dependent, while decreasing HDL in the second trimester correlate with rising levels of human placental lactogen, insulin and insulin resistance. 16 LDL levels increased as the gestational period increases; the LDL level in the second trimester was higher than that in the first trimester and control, whereas the LDL level in the third trimester was only higher than that of the control.…”

“…16 Kumari et al stated that the initial increase in HDL in the first trimester is estrogen-dependent, while decreasing HDL in the second trimester correlate with rising levels of human placental lactogen, insulin and insulin resistance. 16 LDL levels increased as the gestational period increases; the LDL level in the second trimester was higher than that in the first trimester and control, whereas the LDL level in the third trimester was only higher than that of the control. This report is in concordance with those of Blessing et al and Kumari et al which stated an increase in LDL as the gestational period increases.…”

“…This report is in concordance with those of Blessing et al and Kumari et al which stated an increase in LDL as the gestational period increases. 12,16 Similarly, Pusukuru et al carried out a study which evaluated lipid profile in the second and third trimesters of pregnancy, which a report of a significant decrease in LDL in the second trimester, which later became increased in the third trimester of pregnancy. 19 Additionally, it has been noted by Fahraeus et al and Jimenez et al that the levels of LDL in normal pregnancy increased with increasing gestational period.…”

Correlation Between Maternal Dyslipidemia and Preterm Delivery in Tertiary Care Centre- A Clinical Study.

“…The circulating lipids increase during gestation and an increase in the lipid breakdown of lipids causes enhanced availability of lipids to the fetus. [8]. Inflammation and stress, two major contributors to preterm birth, are induced by hyperlipidemia, which is also linked to endothelial dysfunction [9].…”