Assessment of cervical cancer screening policy in Korea for women over age 65

Lee, Sanghoon; Park, Hyun Tae; Song, Jae Yun; Lee, Jae Kwan; Lee, Nak Woo; Kim, T.; Lee, Kyu Wan

doi:10.1016/j.jgo.2013.03.001

Cited by 9 publications

(10 citation statements)

References 10 publications

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“…This raises a concern that a group of older women who are at high risk for cervical cancer are not getting screened. In this context, NHISCSP and NCSP in Korea do include women older than 65 years due to the substantial cervical cancer incidence in this population [ 27 ]. Nevertheless, from 2009 to 2014, the participation rate was lowest among women ≥70 years of age, as also demonstrated by the KNCSS data.…”

Section: Discussionmentioning

confidence: 99%

Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014

et al. 2017

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ObjectiveThe rates of participation in the Korean nationwide cervical cancer screening program and the rates of abnormal test results were determined.MethodsThe database of the National Health Insurance Service (NHIS) was used during the study period (2009–2014).ResultsThe participation rate increased from 41.10% in 2009 to 51.52% in 2014 (annual percentage change, 4.126%; 95% confidence interval [CI]=2.253–6.034). During the study period, women ≥70 years of age had the lowest rate of participation (range, 21.7%–31.9%) and those 30–39 years of age the second-lowest (27.7%–44.9%). The participation rates of National Health Insurance beneficiaries (range, 48.6%–52.5%) were higher than those of Medical Aid Program (MAP) recipients (29.6%–33.2%). The rates of abnormal results were 0.65% in 2009 and 0.52% in 2014, with a decreasing tendency in all age groups except the youngest (30–39 years). Every year the abnormal result rates tended to decrease with age, from the age groups of 30–39 years to 60–69 years but increased in women ≥70 years of age. The ratio of patients with atypical squamous cells of undetermined significance compared with those with squamous intraepithelial lesions increased from 2.71 in 2009 to 4.91 in 2014.ConclusionDifferences related to age and occurring over time were found in the rates of participation and abnormal results. Further efforts are needed to encourage participation in cervical cancer screening, especially for MAP recipients, elderly women and women 30–39 years of age. Quality control measures for cervical cancer screening programs should be enforced consistently.

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Section: Discussionmentioning

confidence: 99%

Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014

et al. 2017

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“…Despite years of genomic studies aimed at molecular classification of human HCC, there is still concern about lack of overlap between different studies[29]. A computationally oriented approach to resolve discrepancies provided a meta-analysis of several studies with the conclusion that there were three basic subgroups [14].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, we found that in mouse models of HCC that the cell-of-origin plays the dominant role in overall transcriptional patterns irrespective of the initiating oncogene. This sheds light on why it has been difficult to consistently explain the heterogeneity of human HCC based on the underlying genetic alterations [29]. …”

Section: Discussionmentioning

confidence: 99%

Reciprocal Interaction of Wnt and RXR-α Pathways in Hepatocyte Development and Hepatocellular Carcinoma

Chanrion

Sawey

et al. 2015

PLoS ONE

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Genomic analysis of human hepatocellular carcinoma (HCC) is potentially confounded by the differentiation state of the hepatic cell-of-origin. Here we integrated genomic analysis of mouse HCC (with defined cell-of-origin) along with normal development. We found a major shift in expression of Wnt and RXR-α pathway genes (up and down, respectively) coincident with the transition from hepatoblasts to hepatocytes. A combined Wnt and RXR-α gene signature categorized HCCs into two subtypes (high Wnt, low RXR-α and low Wnt, high RXR-α), which matched cell-of-origin in mouse models and the differentiation state of human HCC. Suppression of RXR-α levels in hepatocytes increased Wnt signaling and enhanced tumorigenicity, whereas ligand activation of RXR-α achieved the opposite. These results corroborate that there are two main HCC subtypes that correspond to the degree of hepatocyte differentation and that RXR-α, in part via Wnt signaling, plays a key functional role in the hepatocyte-like subtype and potentially could serve as a selective therapeutic target.

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“…In South Korea, for example, there is no upper age limit for screening and two different sets of recommendations are in place [59,70]. Australia's and New Zealand's organised programmes do not invite eligible women for screening and instead have a reminder system that calls only previously screened women who are overdue for a Pap test.…”

Section: Descriptions Of Organised Programmes Show Diversity and Incomentioning

confidence: 99%

‘Organised’ cervical screening 45 years on: How consistent are organised screening practices?

Williams

Carter

Rychetnik

2014

European Journal of Cancer

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Organised screening programmes have been remarkably successful in reducing incidence and mortality from cervical cancer, while opportunistic screening varies in its effectiveness. Experts recommend that cervical screening or HPV testing be carried out only in the context of an organised programme. We sought to answer the following study questions: What does it mean for a cervical screening programme to be organised? Is there a place for opportunistic screening (in an organised programme)? We reviewed 154 peer-reviewed papers on organised and opportunistic approaches to cervical screening published between 1970 and 2014 to understand how the term 'organised' is used, formally and in practice. We found that despite broad recognition of a prescriptive definition of organisation, in practice the meaning of organisation is much less clear. Our review revealed descriptions of organised programmes that differ significantly from prescribed norms and from each other, and a variety of ways that opportunistic and organised programmes intersect. We describe the breadth of the variation in cervical cancer screening programmes and examine the relationships and overlaps between organised and opportunistic screening. Implications emerging from the review include the need to better understand the breadth of organisation in practice, the drivers and impacts of opportunistic screening and the impact of opportunistic screening on population programme outcomes. Appreciation of the complexity of cervical screening programmes will benefit both screeners and women as programmes are changed to reflect a partially vaccinated population, new evidence and new technologies.

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Assessment of cervical cancer screening policy in Korea for women over age 65

Cited by 9 publications

References 10 publications

Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014

Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014

Reciprocal Interaction of Wnt and RXR-α Pathways in Hepatocyte Development and Hepatocellular Carcinoma

‘Organised’ cervical screening 45 years on: How consistent are organised screening practices?

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