Assessment of cerebral hemodynamics during neurosurgical procedures using laser speckle image analysis

Venugopal, Krishnapriya; Sujatha, N.; Bach, Annika; Conzen, Catharina; Lindauer, Ute

doi:10.1002/jbio.201800408

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Venugopal et al. [ 177 ] investigated the CBF response to a cistern magna injection, which is widely used to mimic aneurysmal subarachnoid hemorrhage. The speckle pattern fractal analysis based on the Hurst exponent showed better sensitivity in the assessment of CBF changes during aneurysmal subarachnoid hemorrhage compared to common LSCI analysis.…”

Section: Recent Progress In Dls‐based Imaging Of Blood Flowmentioning

confidence: 99%

Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

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Dynamic light scattering (DLS) is a well known experimental approach uniquely suited for the characterization of small particles undergoing Brownian motion in randomly inhomogeneous turbid scattering medium, including water suspension, polymers in solutions, cells cultures, and so on. DLS is based on the illuminating of turbid medium with a coherent laser light and further analyzes the intensity fluctuations caused by the motion of the scattering particles. The DLS‐based spin‐off derivative techniques, such laser Doppler flowmetry (LDF), diffusing wave spectroscopy (DWS), laser speckle contrast imaging (LSCI), and Doppler optical coherence tomography (DOCT), are exploited widely for non‐invasive imaging of blood flow in brain, skin, muscles, and other biological tissues. The recent advancements in the DLS‐based imaging technologies in frame of their application for brain blood flow monitoring, skin perfusion measurements, and non‐invasive blood micro‐circulation characterization are overviewed. The fundamentals, breakthrough potential, and practical findings revealed by DLS‐based blood flow imaging studies, including the limitations and challenges of the approach such as movement artifacts, non‐ergodicity, and overcoming high scattering properties of studied medium, are also discussed. It is concluded that continued research and further technological advancements in DLS‐based imaging will pave the way for new exciting developments and insights into blood flow diagnostic imaging.

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Section: Recent Progress In Dls‐based Imaging Of Blood Flowmentioning

confidence: 99%

Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

View full text Add to dashboard Cite

show abstract

Enhancing Transcranial Blood Flow Visualization with Dynamic Light Scattering Technologies: Advances in Quantitative Analysis

Zherebtsov,

Sdobnov,

Sieryi

et al. 2024

Laser & Photonics Reviews

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A comparative application of major dynamic light scattering (DLS)‐based image methodologies applied to transcranial cerebral blood flow imaging is presented. In particular, the study delves into assessing capability of Laser Doppler Flowmetry (LDF), Laser Speckle Contrast Imaging (LSCI), and Diffuse Correlation Spectroscopy (DCS) in enhancing the spatial and temporal resolution of transcranial blood flow imaging. An integral part of the study is focused on the modulation of blood flow through the administration of the vasodilator drug, Sodium Nitroprusside (SNP). This pharmacological intervention facilitated a direct observation of cerebral vasculature's responsiveness to external stimuli, illuminating the physiological adaptations within the brain's microvascular architecture. Advanced LSCI processing techniques are incorporated, notably entropy and principal component analysis (PCA). Entropy is providing a quantifiable measure of the randomness and complexity within the speckle patterns of transcranial blood flow images, revealing remarkably similar outcomes with DSC approach in terms of blood flow dynamics and its quantitative evaluation. The application of PCA approach is provided a more nuanced understanding of blood flow dynamics, facilitating the identification of subtle changes induced by drug administration. This method proved instrumental in enhancing the visualization and detection of nuanced blood flow dynamics, thereby allowing for a more detailed examination of cerebral circulation alterations induced by SNP administration. The study seeks to offer a wider‐ranging insight into comprehending the translating further the concept of DLS into transcrainial blood flow vizualization and explore its practical applications, considering hardware, advanced quantitative image processing, and data acquisition.

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Animal model of assessing cerebrovascular functional reserve by imaging photoplethysmography

Mamontov

Sokolov

Volynsky

et al. 2020

Sci Rep

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Assessment of the cerebral blood-flow-reserve in patients with cerebrovascular diseases is extremely important in terms of making prognosis, determining treatment tactics, and controlling the revascularization outcome in the case of reconstructive interventions on the brain vessels. However, there is no easy-to-use, contactless method for either assessing the functional reserve of the cortical vascular network or intraoperative monitoring of surgical intervention. Our study aims to demonstrate feasibility of green-light imaging photoplethysmography (iPPG) to estimate cerebrovascular functional reserve in animal model of craniosurgical intervention. Custom-made iPPG system was exploited to visualize intracranial vessels in anesthetized Wistar rats (n = 15). Video frames of rat’s cortex were recorded concurrently with systemic blood pressure, end-tidal CO2, and electrocardiogram. We found that injection of dorzolamide (carbonic-anhydrase inhibitor) significantly increased the blood-pulsations amplitude in all animals by 35 ± 19% (p < 0.001). Such an increase negatively correlated with significant decrease in end-tidal CO2 by 32 ± 7% (p < 0.001). It is noteworthy that the dorzolamide injection did not lead to significant changes in systemic blood pressure. Concluding, pulsations amplitude is a marker of the vascular tone that can be used to evaluate the functional cerebrovascular reserve. Imaging PPG is a simple and convenient method to assess cerebral blood flow, including during various neurosurgical interventions.

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Assessment of cerebral hemodynamics during neurosurgical procedures using laser speckle image analysis

Cited by 3 publications

References 34 publications

Advances in Dynamic Light Scattering Imaging of Blood Flow

Advances in Dynamic Light Scattering Imaging of Blood Flow

Enhancing Transcranial Blood Flow Visualization with Dynamic Light Scattering Technologies: Advances in Quantitative Analysis

Animal model of assessing cerebrovascular functional reserve by imaging photoplethysmography

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