Assessment of cell-specific cytotoxic responses of the kidney to selected aromatic hydrocarbons

Metabolic Responses of Fish Following Exposure to Two Different Oil Spill Remediation Techniques

“…Gill permeability may be a!ected by the surfactants contained in the dispersants that are designed to dissolve lipids and are nonspeci"c, acting on the lipid bilayer of living cells, causing alteration of membrane permeability (Khan et al, 1986). If gill permeability is altered, there may be leakage of LDH from the tissue (Bowes and Ramos, 1994).…”

Retinal Pigment Epithelial Cell DNA is Damaged by Exposure to Benzo[ a ]pyrene, a Constituent of Cigarette Smoke

“…Mammalian cells differ markedly in their abilities to metabolise PAH compounds according to both the species and tissue of origin. In the case of BaP, similar in vitro investigations with other cell types have routinely employed extracellular concentrations of 10±100 mM (Barnea and Avigdor, 1991;Roggeband et al, 1994;Topinka et al, 1998;Binkova  et al, 2000) or above (Bowes and Ramos, 1994;Uhl, Helma and Knasmu È ller, 2000;Yusuf et al,. 2000).…”

Antagonistic Interactions Among Nephrotoxic Polycyclic Aromatic Hydrocarbons

“…Cortico-tubular epithelial cells represent a heterogenous population of cells that make up the parenchyma of the tubular conduit (Herbert & Kriz, 1993) and are a common site of xenobiotic-induced injury (Schnellman & Goldstein, 1996;Trump et al, 1984). Cell-and class-specific differences in nephrotoxic potential among selected AHs have been previously described (Bowes & Ramos, 1994;Parrish et al, 1998). In general, rat GMCs (rGMCs) were more susceptible to AH-induced cytotoxicity than rat tubular epithelial cells, but both renal cell populations were targeted as part of the nephrotoxic response to this broad class of chemicals.…”