Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study

Wu, Pengfei; Lu, Hui; Zhou, Xiaoting; Liang, Xuchen; Li, Ruizhuo; Zhang, Wan; Li, Danyang; Xia, Kun

doi:10.1016/j.jshs.2021.01.008

Cited by 19 publications

(11 citation statements)

References 42 publications

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“…Identifying potential exposure-related risk factors that can be modified or reduced is important so that these risks can be minimized and eliminated. These findings from NFL football players may also provide insight into other groups that share specific exposures, such as individuals playing other contact sports and military veterans with RHI exposure, elite athletes with high physical activity, and gardeners with pesticide and fertilizer exposure . Further study is therefore warranted to clarify the causal mechanisms underlying the association between duration of professional football play and incidence of ALS.…”

Section: Discussionmentioning

confidence: 91%

“…19 Strenuous physical activity has also been implicated in the risk of ALS. [20][21][22] We sought to clarify the association between ALS diagnosis and NFL participation by determining ALS incidence and mortality relative to the general population, and by examining the association between years of NFL exposure and ALS. We hypothesized that ALS incidence and mortality would be increased in NFL athletes compared with the general population, adjusting for age, sex, and race.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, environmental toxins are a proposed risk factor for ALS . Strenuous physical activity has also been implicated in the risk of ALS …”

Section: Introductionmentioning

confidence: 99%

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Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes

et al. 2021

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“…In contrast, wearable accelerometers provide a mechanism for precise and reproducible activity measurement. Recently, accelerometer-measured physical activity has been associated with lower risks of cardiovascular 12 and neurological disease 15 , as well as overall mortality 9 . Our findings extend prior results by quantifying associations with accelerometer-measured activity across a broad spectrum of disease, exploring physical activity dose-response relationships, and benchmarking the relative utility of device-measured versus self-reported activity as a marker of disease risk.…”

Section: Discussionmentioning

confidence: 99%

Wearable accelerometer-derived physical activity and incident disease

et al. 2022

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Physical activity is regarded as favorable to health but effects across the spectrum of human disease are poorly quantified. In contrast to self-reported measures, wearable accelerometers can provide more precise and reproducible activity quantification. Using wrist-worn accelerometry data from the UK Biobank prospective cohort study, we test associations between moderate-to-vigorous physical activity (MVPA) – both total MVPA minutes and whether MVPA is above a guideline-based threshold of ≥150 min/week—and incidence of 697 diseases using Cox proportional hazards models adjusted for age, sex, body mass index, smoking, Townsend Deprivation Index, educational attainment, diet quality, alcohol use, blood pressure, anti-hypertensive use. We correct for multiplicity at a false discovery rate of 1%. We perform analogous testing using self-reported MVPA. Among 96,244 adults wearing accelerometers for one week (age 62 ± 8 years), MVPA is associated with 373 (54%) tested diseases over a median 6.3 years of follow-up. Greater MVPA is overwhelmingly associated with lower disease risk (98% of associations) with hazard ratios (HRs) ranging 0.70–0.98 per 150 min increase in weekly MVPA, and associations spanning all 16 disease categories tested. Overall, associations with lower disease risk are enriched for cardiac (16%), digestive (14%), endocrine/metabolic (10%), and respiratory conditions (8%) (chi-square p < 0.01). Similar patterns are observed using the guideline-based threshold of ≥150 MVPA min/week. Some of the strongest associations with guideline-adherent activity include lower risks of incident heart failure (HR 0.65, 95% CI 0.55–0.77), type 2 diabetes (HR 0.64, 95% CI 0.58–0.71), cholelithiasis (HR 0.61, 95% CI 0.54–0.70), and chronic bronchitis (HR 0.42, 95% CI 0.33–0.54). When assessed within 456,374 individuals providing self-reported MVPA, effect sizes for guideline-adherent activity are substantially smaller (e.g., heart failure HR 0.84, 95% CI 0.80–0.88). Greater wearable device-based physical activity is robustly associated with lower disease incidence. Future studies are warranted to identify potential mechanisms linking physical activity and disease, and assess whether optimization of measured activity can reduce disease risk.

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“…However, the differential metabolites identified were used to perform cluster analyses using the R package (Wu et al. 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators

Wen

Yang

et al. 2022

Veterinary Quarterly

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The complex etiopathology of retained placenta (RP) and hazards associated with it has made it crucial for researchers and clinical veterinarians to study pathogenesis, early-warning diagnosis, and treatment. This study aimed to screen the potential prognostic markers of RP in dairy cows using plasma metabolomics coupled with clinical laboratory indicators. Blood samples were collected from 260 dairy cows at 21, 14, 7, and 0 days before parturition and 7, 14, and 21 days after parturition. Consequently, 10 healthy cows and 10 cows with RP with similar parity, body condition score, and age were included in the study. The changes in clinical laboratory indicators of the enrolled cows from 21 before parturition to 21 days after parturition were assessed. After initial overview of the multivariate statistical data using PCA analysis, the data were subjected to orthogonal partial least-squares discriminant analysis. Compared with cows with RP at 7 days before parturition, the levels of endothelin and 6-keto-prostaglandin F1α were increased in healthy cows, while the level of estradiol and progesterone decreased. Adenine dinucleotide phosphate, hypoxanthine, guanine dinucleotide phosphate, inosine monophosphate, and L-arginine were revealed as potential prognostic markers of cows with RP at 7 days before parturition involved in the regulation of taste transduction, purine and glutathione metabolism, and autophagy. The best period for the early-warning diagnosis of RP in dairy cows is 7 days before parturition, and purine metabolism and autophagy may play a vital role in the occurrence and development of RP in dairy cows.

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Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study

Cited by 19 publications

References 42 publications

Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes

Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes

Wearable accelerometer-derived physical activity and incident disease

Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators

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