Assessment of Cardiac Functions in Neonatal Sepsis

Hassan, Mohamed Shaffik; Hakeem, Ahmed A.S. El; Abdelmotalep, Mahmoud; El-Dahshan, Tarek

doi:10.21608/aimj.2021.100730.1604

Cited by 1 publication

(5 citation statements)

References 5 publications

(8 reference statements)

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“…According to tissue Doppler analysis, the right ventricle's diastolic function represented by the tricuspid E/A ratio, was found to be considerably poorer in the examined neonates with sepsis than in the aseptic group indicating right ventricular diastolic dysfunction. This is consistent with the study by Abdel Hakeem et al which showed that the tricuspid E/A ratio was lower in cases than in control (25) .…”

Section: Regardingsupporting

confidence: 93%

“…Also, septic patients' group had higher left atrial diameter compared to healthy group. Additionally, Abdel Hakeem et al revealed that the septic group had greater pulmonary artery pressure than the healthy group, validating our findings (25) .…”

Section: Regardingsupporting

confidence: 90%

“…As regards echocardiographic findings in cases and control; LVESD and LVEDD were lower in septic compared to aseptic neonates, this may be related to hemodynamic alteration and profound hypovolemia due to sepsis, which can induce myocardial depression and dysfunction. This went with the findings of the studies by Abdel Hakeem et (25)(26)(27)(28) .…”

Section: Camargo Et Al Classified Eos Accordingsupporting

confidence: 87%

“…The inflammation causes endothelial dysfunction and microvascular leakage, leading to decreased tissue perfusion and oxygen delivery to the myocardium. Reduced oxygen supply to the myocardium can further impair its contractile function and contribute to decreased EF (25) .…”

Section: Regardingmentioning

confidence: 99%

“…Nitric oxide, on the other hand, can impair myocardial contractility by inhibiting the intracellular calcium handling process within the cardiomyocytes. Disrupted calcium signaling impairs the myocardial contractile apparatus, which is essential for proper myocardial contraction (25) .…”

Section: Regardingmentioning

confidence: 99%

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Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis

El sayed,

Hegazy,

Habeed

et al. 2024

Ain Shams Medical Journal

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Background: Neonatal sepsis is a serious condition with increased morbidity and mortality. Cardiac complications are common sequalae for neonatal sepsis with poor prognosis. Utilization of biomarkers for early detection of these cardiac complications helps in improving the prognosis. Aim of the work: Detect the reliability of plasma copeptin and ischemia-modified albumin (IMA) as indicators of cardiac involvement in neonatal sepsis. Patients and methods:The current study included 70 late preterm neonates divided into 3 groups; 30 neonates diagnosed with sepsis and cardiac affection (group 1), 20 neonates diagnosed with sepsis without cardiac affection (group 2) and 20 matched neonates free of sepsis and cardiac affection (group 3). All included neonates had a full history taking, general and local examination. In addition to measuring serum copeptin and IMA levels. Cardiac functions were assessed by transthoracic echocardiography and tissue doppler imaging.Results: A significantly higher mean value of copeptin in group 1 (12.26 ± 4.06 ng/ml), followed by group 2 (4.25±1.56 ng/ml), then group 3 (2.17±0.79 ng/ml) (p<0.001). Also, IMA was significantly higher in group 1 (263.97±81.49 ng/ml), followed by group 2 (68.62±22.08 ng/ml), then group 3 (35.94±10.94 ng/ml) (p<0.001). There was a significant positive correlation between copeptin with IMA. Conclusion:Serum Copeptin and IMA levels are good predictors for detection of cardiac complications in neonatal sepsis besides their role in sepsis detection itself.

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Section: Regardingsupporting

confidence: 93%

Section: Regardingsupporting

confidence: 90%