Assessment of cardiac autonomic tone in conscious rats

Sayin, Halil; Chapuis, Bruno; Chevalier, Philippe; Barrès, Christian; Julien, Claude

doi:10.1016/j.autneu.2015.12.007

Cited by 12 publications

(20 citation statements)

References 32 publications

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“…Intrinsic intervals were considered the value after combined cardiac autonomic blockade and represents the spontaneous interval in the absence of autonomic modulation. When parasympathetic effect or tonus dominate, control intervals are above intrinsic intervals; however, when sympathetic effect or tonus dominate, control intervals are lower than intrinsic intervals (note that intervals are reciprocals of rate) (Goldberger 1999; Sayin et al 2016). …”

Section: Methodsmentioning

confidence: 99%

“…In addition to activation of the parasympathetic and sympathetic divisions, the complex and interacting influences on the autonomic nervous system on cardiovascular function can also be studied indirectly by using pharmacological cardiac autonomic blockade (Sayin et al 2016; Chen et al 1995a). Results obtained from these studies have been analyzed by a variety of approaches.…”

Section: Introductionmentioning

confidence: 99%

“…In an attempt to reduce the influence of these two suggested limitations, investigators have used parasympathetic and sympathetic tonus (Gava et al 1995; Negrão et al 1992; Chen and DiCarlo 1997; Sayin et al 2016). Parasympathetic tonus is defined as the difference between the intrinsic value and the value after beta1-adrenergic receptor blockade.…”

Section: Introductionmentioning

confidence: 99%

“…By using sympathetic and parasympathetic tonus, investigators are also able to account for any potential change in intrinsic heart rate. However, it is important to note that no consensus exists on the use of these two approaches (Sayin et al 2016). …”

Section: Introductionmentioning

confidence: 99%

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Complex and interacting influences of the autonomic nervous system on cardiac electrophysiology in conscious mice

Lujan

Rivers

DiCarlo

2016

Autonomic Neuroscience

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Mice may now be the preferred animal model for biomedical research due to its anatomical, physiological, and genetic similarity to humans. However, little is known about accentuated antagonism of chronotropic and dromotropic properties in conscious mice. Accordingly, we describe the complex and interacting influence of the autonomic nervous system on cardiac electrophysiology in conscious mice. Specifically, we report the effects of single and combined cardiac autonomic blockade on measurements of pulse interval (heart rate), atrio-ventricular interval, sinus node recovery time (SNRT), SNRT corrected for spontaneous sinus cycle, and Wenckebach cycle length in conscious mice free of the confounding influences of anesthetics and surgical trauma. Autonomic influences were quantified as the change in parameter induced by its selective blocker (Sympathetic or Parasympathetic Effect) or as the difference between the intrinsic value and the value after a selective blocker (Sympathetic or Parasympathetic Tonus). Sympatho-Vagal Balance (SVB) was assessed as the ratio of control interval to intrinsic interval. SVB suggests slight parasympathetic dominance in the control of cardiac electrophysiology intervals. Furthermore, results documents a complex interaction between the sympathetic and parasympathetic divisions of the autonomic nervous system in the control of cardiac electrophysiology parameters. Specifically, the parasympathetic effect was greater than the parasympathetic tonus in the control of cardiac electrophysiology parameters. In contrast, the sympathetic effect was smaller than the sympathetic tonus in the control of cardiac electrophysiology parameters. Results have important implications because actions of pharmacological agents that alter the autonomic control of cardiac electrophysiology are transformed by these interacting mechanisms.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complex and interacting influences of the autonomic nervous system on cardiac electrophysiology in conscious mice

Lujan

Rivers

DiCarlo

2016

Autonomic Neuroscience

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“…[5,6] Autonomic tone refers to the resting basal discharge or basal activity free from physiological perturbations or challenges. [7] This is in sharp contrast to autonomic reactivity which measures the degree of change or activity of a system in response to a given stimulus. [8] Autonomic tone is usually communicated in scientific literature as autonomic balance or sympathovagal balance, which does not indicate the absolute magnitude of activity of parasympathetic and sympathetic system but only the ratio of two activities.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in cardiovascular autonomic milieu and its association with academic performance in young adults

Dharmalingam¹,

Manjeshwara²,

Hariharan³

2017

Natl J Physiol Pharm Pharmacol

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Background: Initiated by biological plausibility and supported by the pilot study, we observed possibility of associations between cardiovascular autonomic milieu and academic performances. As there are established cognitive ability differences among gender in literature, we designed a study to observe the differences in the basal autonomic activity as well as the manner of association between autonomic activity and academic performance between genders. Considerable lacunae in literature on this aspect also warranted for scientific introspection on this lacuna. Aims and Objective: The aim of this study is to observe the association between resting short-term heart rate variability (HRV) indices and University marks of anatomy, biochemistry, and physiology in young male and female medical students. Materials and Methods: Cross-sectional observational study with 102 healthy young participants in which 34 boys and 68 girls between 18 and 22 years were included by convenient sampling after assessing the inclusion and exclusion criteria. HRV is computed under standard conditions as per the task force recommendations in time and frequency domains. The academic performance is assessed by University examination marks at the end of the 1 st year. The comparison of HRV parameters, academic performance, and their associations was analyzed separately by gender. Type 1 error allowance fixed at 5% but considering the high dispersion of HRV data, P values between 0.1 and 0.05 were also discussed. Results: Mean RR intervals showed a negative correlation with academic performance in males. Time domain and geometric indices of HRV showed a negative correlation in boys but not in girls. In case of frequency domain indices, all indices of sympathetic activity showed a positive correlation with academic performance in boys and not in girls. Furthermore, sympathetic indices are more in males compared to females. All indices of parasympathetic reactivity were negatively correlated with academic performance in males. Conclusion: High-sympathetic activity is correlated with better cognitive ability in males but the same association is not seen in females.

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Acute poisoning by chlorpyrifos differentially impacts survival and cardiorespiratory function in normotensive and hypertensive rats

Aitken,

Minassa,

Batista

et al. 2024

Chemico-Biological Interactions

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Assessment of cardiac autonomic tone in conscious rats

Cited by 12 publications

References 32 publications

Complex and interacting influences of the autonomic nervous system on cardiac electrophysiology in conscious mice

Complex and interacting influences of the autonomic nervous system on cardiac electrophysiology in conscious mice

Gender differences in cardiovascular autonomic milieu and its association with academic performance in young adults

Acute poisoning by chlorpyrifos differentially impacts survival and cardiorespiratory function in normotensive and hypertensive rats

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