Assessment of cancer stem cell marker expression in primary head and neck squamous cell carcinoma shows prognostic value for aldehyde dehydrogenase (ALDH1A1)

Szafarowski, Tomasz; Sierdziński, Janusz; Ludwig, Nils; Głuszko, Alicja; Filipowska, Anna; Szczepański, Mirosław J.

doi:10.1016/j.ejphar.2019.172837

Cited by 15 publications

(12 citation statements)

References 41 publications

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“…Recent studies suggest that the differential expression of CD44 is likely to depend on the location of lesions. This may be reliable for OLP as well (21).…”

Section: Discussionmentioning

confidence: 92%

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Literature review of cancer stem cells in oral lichen planus: a premalignant lesion

Moosavi¹,

Tavakol²

2021

Stem Cell Investig

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Objective: As there is no review study about cancer stem cells (CSCs) involved in the pathogenesis of oral lichen planus (OLP), for the first time we review the role of these cells in OLP and this hypothesis may be a clue for the evaluation of the premalignancy of OLP.Background: Cellular mediated immune responses are the main etiopathogenesis in OLP and it is a potentially premalignant lesion. One of the factors proposed in the pathogenesis of OLP and the comparable trend of this autoimmune disease to squamous cell carcinoma (SCC) are CSCs. CSCs have been detected in several solid tumors including head and neck cancers, and have special characteristics including metastasis and resistance to chemotherapy.Methods: Related keywords were searched and risk of bias assessment was done for each study.Conclusions: Among all of the studies reviewed in this article, all markers had increased expression in OLP compared to controls that are consistent with SCC. Only CD44 was in contradiction to other papers, in which different expression of CD44 strains was measured in different samples such as saliva and tissue.Based on the results of this review and more studies in the future by investigating the levels of these markers in OLP, it may be possible to determine the prognosis and course of the disease for each patient individually.

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“…Recent studies suggest that the differential expression of CD44 is likely to depend on the location of lesions. This may be reliable for OLP as well (21).…”

Section: Discussionmentioning

confidence: 92%

“…A recent study about CSCs in head and neck SCCs was showed that ALDH1A1 expression significantly higher in head and neck SCC vs. dysplasia, and CD133 expression levels were significantly higher in cancer and dysplasia patients vs. controls (21).…”

Section: Discussionmentioning

confidence: 93%

Literature review of cancer stem cells in oral lichen planus: a premalignant lesion

Moosavi¹,

Tavakol²

2021

Stem Cell Investig

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“…A study involving Iranian prostate cancer patients by Kalantari et al showed that the level of ALDH1A1 expression was positively correlated with tumor invasiveness (46). Among the most common cancer stem cell markers, only ALDH1A1 overexpression significantly affected the five-year OS of primary head and neck squamous cell carcinoma patients (78). ALDH1A1 levels were also higher in papillary thyroid carcinoma tissues than in normal thyroid tissues.…”

Section: Aldh1a1 Overexpression Is An Oncogenic Factor In Most Cancersmentioning

confidence: 99%

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

Yue

et al. 2022

Front. Oncol.

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Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers via the maintenance of cancer stem cell properties, modification of metabolism, promotion of DNA repair. ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully understood. This review will provide insight into the status of ALDH1A1 research and new viewpoint for cancer therapy.

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“… 4 Laryngeal cancer stem cells can be isolated from laryngeal squamous cell carcinoma tissue, and laryngeal cancer stem cells can be used to study the occurrence, development, and treatment strategies of laryngeal cancer, the most common CSCs markers are CD44, CD24, CD133, and ALDH1A1. 5 Previous studies by our group have demonstrated that CD133 is one of the markers of tumor initiating cells in the human laryngeal cancer Hep‐2 cell line, 6 CD133 positive cells have a significant ability to generate new tumors in vivo 7 with stemness phenotype characteristics, 8 and CD133+ laryngeal cancer stem cells have stronger invasive, migratory, and tumorigenic abilities compared with normal laryngeal cancer stem cells. 9 Cucurbitacin E (CuE), an active compound of the cucurbitacin family, is a highly oxidized steroid consisting of tetracyclic triterpenes, which are more promising anticancer triterpenes 10 , 11 with multiple pharmacological functions and chemotherapeutic potential.…”

Section: Introductionmentioning

confidence: 97%

“…Cancer stem cells (CSC) are a small subpopulation of cancer cells with self‐renewal potential, capable of maintaining tumor growth and cell differentiation, involved in metastatic process, recurrence, and resistance to chemotherapeutic agents, 1 and may be the main source of cancer invasion, migration and extensive metastasis, , 2,3 laryngeal squamous cell carcinoma in the second rank of head and neck squamous cell carcinoma; tumor stem cells (CSC) play a key role in the development and progression of head and neck squamous cell carcinoma (HNSCC), and can result tumor growth and malignant behavior 4 . Laryngeal cancer stem cells can be isolated from laryngeal squamous cell carcinoma tissue, and laryngeal cancer stem cells can be used to study the occurrence, development, and treatment strategies of laryngeal cancer, the most common CSCs markers are CD44, CD24, CD133, and ALDH1A1 5 . Previous studies by our group have demonstrated that CD133 is one of the markers of tumor initiating cells in the human laryngeal cancer Hep‐2 cell line, 6 CD133 positive cells have a significant ability to generate new tumors in vivo 7 with stemness phenotype characteristics, 8 and CD133+ laryngeal cancer stem cells have stronger invasive, migratory, and tumorigenic abilities compared with normal laryngeal cancer stem cells 9 .…”

Section: Introductionmentioning

confidence: 99%

Study on the chemotherapeutic effect and mechanism of cucurbitacin E on laryngeal cancer stem cells

Jiang¹,

Wei

et al. 2022

Laryngoscope Investig Oto

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Objectives: Study on the chemotherapeutic effect and mechanism of cucurbitacin E (CuE) on laryngeal cancer stem cells. Methods: We used flow cytometry to sort out CD133 + laryngeal cancer stem cells; trypan blue rejection assay to detect the survival rate of laryngeal cancer stem cells; Cell counting kit-8 (CCK-8) assay to detect the effect of CuE on the proliferation ability of stem cells and the chemotherapeutic potentiation of doxorubicin; Transwell assay to observe the effect of CuE on the migration ability of stem cells; and Western Blot to detect the effect of CuE on the expression level of stem cell-associated proteins. The tumor volume of nude mice was measured at the end of the experiment, and paraffin sections of nude mice tumor tissues were prepared and stained with Hematoxylin and eosin (H&E). The expression of c-MYC in tumor tissues of nude mice was further detected by immunohistochemistry, and the effect of CuE on the expression level of related proteins in tumor tissues of nude mice was detected by Western Blot.Results: CuE reduced the survival rate, proliferation ability, and migration ability of laryngeal cancer stem cells in vitro, and that CuE had a chemotherapeutic potentiating effect on doxorubicin. The possible mechanism of the chemotherapeutic effect of CuE was to reduce the expression of c-MYC protein, and the possible mechanism of chemotherapy synergy was to reduce the expression of ABCG2 and P-gp protein. Conclusion:CuE has a chemotherapeutic effect on laryngeal cancer stem cells, as well as a chemotherapy synergy.

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Assessment of cancer stem cell marker expression in primary head and neck squamous cell carcinoma shows prognostic value for aldehyde dehydrogenase (ALDH1A1)

Cited by 15 publications

References 41 publications

Literature review of cancer stem cells in oral lichen planus: a premalignant lesion

Literature review of cancer stem cells in oral lichen planus: a premalignant lesion

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

Study on the chemotherapeutic effect and mechanism of cucurbitacin E on laryngeal cancer stem cells

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