Assessment of cancer-related fatigue among cancer patients receiving various therapies: A cross-sectional observational study

Banipal, Raja Paramjeet Singh; Singh, Harminder; Singh, Baltej

doi:10.4103/ijpc.ijpc_135_16

Cited by 35 publications

(31 citation statements)

References 22 publications

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“…More work is needed in these areas to better support CRC survivors. Fatigue is a common problem in many cancers [60] including CRC but no study specifically explored this issue. Further, no study aimed to assess cognitive functioning, genetic or heredity issues.…”

Section: Critical Gaps In the Evidencementioning

confidence: 99%

Patient-reported outcomes and experiences from the perspective of colorectal cancer survivors: meta-synthesis of qualitative studies

Rutherford

Müller

Faiz

et al. 2020

J Patient Rep Outcomes

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Background: Colorectal cancer (CRC) is prevalent in the developed world. Favourable survival rates highlight the need to better understand CRC survivors' experiences of long-term impacts of treatment, which can in turn inform decision making. This systematic review aimed to identify and synthesise CRC survivors' experiences of long-term impacts on health-related quality of life. Methods: We searched Medline, Embase and PsychINFO from inception to January 2019. Qualitative studies describing CRC survivors' experiences at least 1-year post-treatment were included. Study eligibility, quality assessment (COREQ guidelines), and data synthesis was performed independently by two reviewers and discussed with the study team. Results: Of 1363 papers retrieved, 20 reporting 15 studies met eligibility. Thematic synthesis produced 12 themes: symptoms, physical, social, psychological and sexual functioning, impact on relationships, informal care needs provided by family/friend, supportive care needs provided by healthcare professional, health care experiences, health behaviour, financial toxicity and occupational experiences. Stoma problems (e.g. leakage, skin irritation) were common in ostomates. Survivors with no/reversed stoma experienced unexpected, longterm altered and unpredictable bowel functioning. Survivors often regulated timing, amount and foods consumed to manage bowel functioning. Less common symptoms included fatigue, impaired sleep and anal pain. Stoma problems and altered bowel functioning impaired survivors' physical, social, sexual and psychological functioning. Cognitive functioning and heredity issues were not reported in any paper. Conclusion: CRC survivors experience ongoing symptoms and functioning impairments more than 1-year posttreatment completion. Many survivors find their own ways to manage symptoms rather than seek professional help. Follow-up care for CRC survivors should integrate screening for long-term effects and provide targeted supportive care.

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Section: Critical Gaps In the Evidencementioning

confidence: 99%

Patient-reported outcomes and experiences from the perspective of colorectal cancer survivors: meta-synthesis of qualitative studies

Rutherford

Müller

Faiz

et al. 2020

J Patient Rep Outcomes

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“…Cancer-related fatigue (CRF) is one of the common, suffering and persistent symptoms of cancer patients, often accompanied by the entire course of malignancy. The prevalence of CRF may vary with an estimate of 60%–96% in malignant tumor patients who are undergoing treatment and experiencing fatigue [1, 2]. Unlike the transient fatigue of normal healthy people, the incidence of CRF is sudden, with the subjective sense of tiredness or exhaustion which is not proportional to recent physical activity and interferes with usual functioning; rest or sleep cannot alleviate it [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Zhang

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Fatigue is a common, distressing, and persistent symptom for patients with malignant tumor including colorectal cancer (CRC). Although studies of cancer-related fatigue (CRF) have sprung out in recent years, the pathophysiological mechanisms that induce CRF remain unclear, and effective therapeutic interventions have yet to be established. Methods. To investigate the effect of the traditional Chinese medicine YangZheng XiaoJi (YZXJ) on CRF, we constructed orthotopic colon cancer mice, randomly divided into YZXJ group and control (NS) group. Physical or mental fatigue was respectively assessed by swimming exhaustion time or suspension tail resting time. At the end of the experiment, serum was collected to measure the expression level of inflammatory factors by ELISA and feces to microbiota changes by 16s rDNA, and hepatic glycogen content was detected via the anthrone method. Result. The nutritional status of the YZXJ group was better than that of the control group, and there was no statistical difference in tumor weight. The swimming exhaustion times of YZXJ group and control group were (162.80 ± 14.67) s and (117.60 ± 13.42, P < 0.05) s, respectively; the suspension tail resting time of YZXJ group was shorter than that of the control group (49.85 ± 4.56) s and (68.83 ± 7.26) s, P < 0.05)). Serum levels of IL-1β and IL-6 in YZXJ group were significantly lower than the control group (P < 0.05). Liver glycogen in YZXJ group was (5.18 ± 3.11) mg/g liver tissue, which was significantly higher than that in control group (2.95 ± 2.06) mg/g liver tissue (P < 0.05). At phylum level, increased abundance of Bacteroidetes, Verrucomicrobia, Actinobacteria, and Cyanobacteria and decreased Proteobacteria in YZXJ group emerged as the top differences between the two groups, and the Firmicutes/Bacteroidetes ratio was decreased in YZXJ group compared to the control group. At genus level, the abundance of Parabacteroides, unidentified Saprospiraceae, and Elizabethkingia which all belong to phylum Bacteroidetes were increased, while Arcobacter, Marinobacter, Alkanindiges, Sulfuricurvum, Haliangium, and Thiobacillus in phylum Proteobacteria were decreased after YZXJ intervention. YZXJ can also increase Pirellula, Microbacterium, and Alpinimonas and decrease Rubrobacter and Iamia. Conclusion. YZXJ may reduce the physical and mental fatigue caused by colorectal cancer by inhibiting inflammatory reaction, promoting hepatic glycogen synthesis, and changing the composition of intestinal microbiota.

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“…Fatigue was reported as a significant predictor of impaired HRQoL and poor survival in leukemia patients [20]. Fatigue can adversely disturb patients' adherence to the treatment regime and can be doselimiting [25] The ROC analysis showed that the cut-off score for good HRQoL in our study sample (FACT-Lue) was ≥126 of 174. Overall, HRQoL mean score (104.89±28.82) assessed by FACT-Leu was below the optimal cut-off score indicating poor HRQoL among our leukemia patients.…”

Section: Discussionmentioning

confidence: 66%

“…Fatigue was reported as a significant predictor of impaired HRQoL and poor survival in leukemia patients [ 20 ]. Fatigue can adversely disturb patients’ adherence to the treatment regime and can be dose-limiting [ 25 ]…”

Section: Discussionmentioning

confidence: 99%

Clinically Significant Fatigue in Adult Leukemia Patients: Prevalence, Predictors, and Impact on Quality of Life

AlFayyad¹,

Al-Tannir²,

Yaqub³

et al. 2020

Cureus

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Assessment of cancer-related fatigue among cancer patients receiving various therapies: A cross-sectional observational study

Cited by 35 publications

References 22 publications

Patient-reported outcomes and experiences from the perspective of colorectal cancer survivors: meta-synthesis of qualitative studies

Patient-reported outcomes and experiences from the perspective of colorectal cancer survivors: meta-synthesis of qualitative studies

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Clinically Significant Fatigue in Adult Leukemia Patients: Prevalence, Predictors, and Impact on Quality of Life

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