Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers
Muhammad Bilal,
Sami Ullah,
Ulrich Jaehde
et al.
Abstract:Purpose
Currently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight (BW). The present evaluation aimed to assess the influence of body mass-related covariates on rifampicin’s pharmacokinetics (PK) parameters in more detail using non-linear mixed effects modeling (NLMEM).
Methods
Twenty-four healthy Caucasian volunteers were enrolled in a bioequivalence study, each receiving a … Show more
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