Assessment of biocompatibility of novel TiTaHf-based high entropy alloys for utility in orthopedic implants

Gurel, Sibel; Nazarahari, Alireza; Canadinç, D.; Çabuk, Haluk; Bal, Burak

doi:10.1016/j.matchemphys.2021.124573

Cited by 21 publications

(13 citation statements)

References 49 publications

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“…Three TiTaHf-based HEAs (TiTaHfNb, TiTaHfNbZr, and TiTaHfMoZr) were studied by Gurel et al [25,37,46]. The authors indicated that the addition of Mo and Zr resulted in a reduction in ductility when compared to the four-element alloy.…”

Section: Hv =mentioning

confidence: 99%

“…Since then, this term has been applied for multiprincipal element alloys that have been considered for applications in the biomedical field. The challenge is to overcome the limitations of conventional alloys (cp-Ti, Ti6Al4V, 316L, and CoCrMo alloys), and some promising results were reported concerning superior or similar corrosion resistance and implant degradation in a physiological environment [12][13][14], mechanical performance combined with biocompatibility [14][15][16][17][18][19][20], ion release [21,22], magnetic susceptibility [23,24], wear resistance [12,25], and bacterial infection [19].…”

Section: Introductionmentioning

confidence: 99%

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A Review of Biomaterials Based on High-Entropy Alloys

Oliveira

Fagundes

Capellato

et al. 2022

Metals

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Due to its great amount of microstructure and property possibilities as well as its high thermodynamic stability and superior mechanical performance, the new class of material known as high-entropy alloys (HEAs) has aroused great interest in the research community over the last two decades. Recent works have investigated the potential for applying this material in several strategical conditions such as high temperature structural devices, hydrogen storage, and biological environments. Concerning the biomedical field, several papers have been recently published with the aim of overcoming the limitations of conventional alloys, such as corrosion, fracture, incompatibility with bone tissue, and bacterial infection. Due to the low number of available literature reviews, the aim of the present work is to consolidate the information related to high-entropy alloys developed for biomedical applications (bioHEAs), mainly focused on their microstructure, mechanical performance, and biocompatibility. Topics such as phases, microstructure, constituent elements, and their effect on microstructure and biocompatibility, hardness, elastic modulus, polarization resistance, and corrosion potential are presented and discussed. The works indicate that HEAs have high potential to act as candidates for complementing the materials available for biomedical applications.

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Section: Hv =mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review of Biomaterials Based on High-Entropy Alloys

Oliveira

Fagundes

Capellato

et al. 2022

Metals

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“…TiZrNbTaMo HEA exhibited excellent corrosion resistance comparable to Ti6Al4V alloy and significantly better-pitting resistance than 316 L SS and CoCrMo alloys in a physiological environment simulated by PBS media. Gurel et al ( Gurel et al, 2021 ) studied the biocompatibility of three TiTaHf-based high-entropy alloys, namely TiTaHfNb, TiTaHfNbZr, and TiTaHfMoZr alloys, using FBS as a test environment to compare their corrosion resistance as bone implants by the level of ions released from HEA etched by FBS solution, TiTaHfNb HEA exhibited the highest corrosion resistance to FBS, as shown in Figure 15 . In addition, after 28 days of immersion in FBS solution, the three HEA were found to produce hydroxyapatite on their surfaces when in contact with FBS, further demonstrating their great potential for use in orthopedic implants.…”

Section: Biocompatibilitymentioning

confidence: 99%

“… (A) Potentiodynamic polarization curves of arc-melted TiZrNbTaMo HEA, as well as Ti-6Al-4V, 316L, and CoCrMo alloys in PBS for comparison of biocompatibility ( Wang and Xu, 2017 ). Ti2p peaks after etching times of 360 and 1,080 s immersed in FBS for 28 days: (B) and (C) for TiTaHfNb, (D) and (E) for TiTaHfNbZr, (F) and (G) for TiTaHfMoZr ( Gurel et al, 2021 ). …”

Section: Biocompatibilitymentioning

confidence: 99%

“…In addition, according to Ren et al (Ren et al, 2022), direct contact of bacteria with the copper-rich phase in Bio-HEAs produces an effective concentration of ROS (H 2 O 2 ) during FIGURE 15 (A) Potentiodynamic polarization curves of arc-melted TiZrNbTaMo HEA, as well as Ti-6Al-4V, 316L, and CoCrMo alloys in PBS for comparison of biocompatibility (Wang and Xu, 2017). Ti2p peaks after etching times of 360 and 1,080 s immersed in FBS for 28 days: (B) and (C) for TiTaHfNb, (D) and (E) for TiTaHfNbZr, (F) and (G) for TiTaHfMoZr (Gurel et al, 2021).…”

Section: Antibacterial Propertymentioning

confidence: 99%

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Bio-high entropy alloys: Progress, challenges, and opportunities

Feng

Tang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to the low compatibility of traditional metal implant materials with the human body, it is urgent to develop new biomaterials with excellent mechanical properties and appropriate biocompatibility to solve the adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar alloys of five or more elements, with huge compositional design space and excellent mechanical properties. In contrast, biological high-entropy alloys (Bio-HEAs) are expected to be a new bio-alloy for biomedicine due to their excellent biocompatibility and tunable mechanical properties. This review summarizes the composition system of Bio-HEAs in recent years, introduces their biocompatibility and mechanical properties of human bone adaptation, and finally puts forward the following suggestions for the development direction of Bio-HEAs: to improve the theory and simulation studies of Bio-HEAs composition design, to quantify the influence of composition, process, post-treatment on the performance of Bio-HEAs, to focus on the loss of Bio-HEAs under actual service conditions, and it is hoped that the clinical application of the new medical alloy Bio-HEAs can be realized as soon as possible.

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