Assessment of Aversion of Acute Pain Stimulus through Conditioned Place Aversion

Urien, Louise; Zhang, Qiaosheng; Martinez, Erik; Zhou, Haocheng; Desrosier, Nicole; Dale, Jahrane; Wang, Jing

doi:10.21769/bioprotoc.2595

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…In rodents, the ‘unpleasantness’ of pain and its affective component is usually characterized as an avoidance of the pain stimulus, while pain behaviors such as licking, jumping, and hypersensitivity are assumed to represent sensory-discriminative components of the processing of nociceptive input. Often, the conditioned place avoidance test, which measures the percentage of time spent avoiding an aversive context, is used to distinguish the affective component of pain from its sensory or reflexive aspects (Urien et al, 2017). Using conditioned place avoidance, multiple brain regions have been shown to play crucial roles in encoding the affective components of pain, including: the PFC, ACC, and prelimbic subdivisions (Jiang et al, 2014; Johansen et al, 2001), as well as the central and basolateral nuclei of the amygdala (BLA; Han et al, 2015; Neugebauer, 2015; Tanimoto et al, 2003), as discussed in the following section.…”

Section: Topic Area Reviewmentioning

confidence: 99%

The role of hedonics in the Human Affectome

Becker

Bräscher

Bannister

et al. 2019

Neuroscience & Biobehavioral Reviews

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Experiencing pleasure and displeasure is a fundamental part of life. Hedonics guide behavior, affect decision-making, induce learning, and much more. As the positive and negative valence of feelings, hedonics are core processes that accompany emotion, motivation, and bodily states. Here, the affective neuroscience of pleasure and displeasure that has largely focused on the investigation of reward and pain processing, is reviewed. We describe the neurobiological systems of hedonics and factors that modulate hedonic experiences (e.g., cognition, learning, sensory input). Further, we review maladaptive and adaptive pleasure and displeasure functions in mental disorders and well-being, as well as the experience of aesthetics. As a centerpiece of the Human Affectome Project, language used to express pleasure and displeasure was also analyzed, and showed that most of these analyzed words overlap with expressions of emotions, actions, and bodily states. Our review shows that hedonics are typically investigated as processes that accompany other functions, but the mechanisms of hedonics (as core processes) have not been fully elucidated.

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Section: Topic Area Reviewmentioning

confidence: 99%

The role of hedonics in the Human Affectome

Becker

Bräscher

Bannister

et al. 2019

Neuroscience & Biobehavioral Reviews

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“…It is widely accepted that stress contributes to the severity and frequency of migraine attacks[ 26 , 27 ]. In laboratory studies using animal models, the reward- and/or penalty-conditioned paradigms, such as conditioned place preference (CPP) and/or conditioned place aversion (CPA), are the common procedures to assess the affective component of pain and then analyze its mechanisms[ 34 ]. Animals are conditioned with CPA paradigm where aversive stimuli (like varieties of stress) can “teach” animals to avoid environments (or objects) that are associated with aversive stimuli by psychologically producing negative, unpleasant affect[ 31 ] and by behaviorally inducing avoidance or escape[ 35 ].…”

Section: Unpleasantness Component Of Migraine Painmentioning

confidence: 99%

Contributions of aversive environmental stress to migraine chronification: Research update of migraine pathophysiology

Liu

Wang

Xie

et al. 2021

WJCC

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Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses (plasticity) of dural afferent neurons are initiated contributing to migraine chronification. However, pathophysiological processes and neural circuitry involved in aversion (unpleasantness)-producing migraine chronification are still evolving. An interdisciplinary team conducted this narrative review aimed at reviewing neuronal plasticity for developing migraine chronicity and its relevant neurocircuits and providing the most cutting-edge information on neuronal mechanisms involved in the processing of affective aspects of pain and the role of unpleasantness evoked by internal and/or external cues in facilitating the chronification process of migraine headache. Thus, information presented in this review promotes the understanding of the pathophysiology of chronic migraine and contribution of unpleasantness (aversion) to migraine chronification. We hope that it will bring clinicians’ attention to how the maladaptive neuroplasticity of the emotion brain in the aversive environment produces a significant impact on the chronification of migraine headache, which will in turn lead to new therapeutic strategies for this type of pain.

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