Assessment of Autonomic Function Activity in Obese Children

Bedi, Mona; Khullar, Shilpa; Varshney, Ved Prakash

doi:10.2174/1567270000906010139

Cited by 7 publications

(8 citation statements)

References 13 publications

(12 reference statements)

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“…On inter group comparison of sympathetic tests between normal weight vs obese subjects, results indicated that in obese subjects had increased sympathetic activity at the resting condition and blood pressure response to CPT was significantly lower in obese as compared to normal weight subjects, thus points towards sympathetic insufficiency in obese subjects. Similar results were found in the study by Bedi et al 21 and LeBlanc et al 25 Valensi et al 26 also found sympathetic insufficiency was also associated with obesity. They showed that glucose-induced inhibition of the lipid oxidation rate in obese women was greater in the patients with autonomic dysfunction.…”

Section: Discussionsupporting

confidence: 85%

“…No change in parasympathetic nervous system functioning was found in obese children as compared to normal weight. This was also reported by Bedi et al 21 in "Assessment of Autonomic Function Activity in Obese Children" (2009) and also by Piccirillo et al 22 and Hofmann et al 23 On inter group comparison of parasympathetic tests between normal weight vs overweight and normal weight vs obese subjects it revealed that there is no significant change in parasympathetic activity with an increase in BMI. The mean resting SBP and DBP was highest for obese than for overweight than normal weight and under weight.…”

Section: Discussionsupporting

confidence: 76%

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Effect of Body Mass Index on Cardiac Autonomic Functional Status in Healthy Young Adults

Rafiq¹,

Nabi²,

Nazeer³

2019

IJCMR

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Introduction: Autonomic nervous system (ANS) is involved in energy metabolism and regulation of the cardiovascular system. Autonomic dysfunction has been suggested to occur in obese individuals in both adults and children but a comprehensive study of the autonomic status in young adults is scant. So aim of the study was to evaluate and compare cardiovascular autonomic functions in young adults on the basis of BMI. Material and methods: 150 healthy young students of MMU aged 18-25 years, divided into four groups based on BMI as per Asian criteria (underweight, normal weight, overweight and obese). Various autonomic function tests done were Lying to Standing test, Valsalva manoeuvre, Hand grip test (HGT) and Cold pressor test (CPT). Results:The mean baseline SBP and DBP were significantly higher in obese subjects followed by overweight, normal weight and under weight. No parasympathetic alteration between different BMI groups was seen. Mean values of resting SBP and DBP were significantly higher and blood pressure response to HGT and CPT was significantly lower in obese as compared to normal weight subjects. Conclusion:Our study revealed an altered autonomic function in the form of impaired sympathetic activity with no parasympathetic modulation in obese young adults. So weight reduction and moderate intensity aerobic exercise programmes should be incorporated into daily living, which may delay or prevent the onset of hypertension.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 76%

Effect of Body Mass Index on Cardiac Autonomic Functional Status in Healthy Young Adults

Rafiq¹,

Nabi²,

Nazeer³

2019

IJCMR

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“…The energy balance is to a reasonable extent affected by the status of autonomic nervous system (ANS) activity in the individual. [5] Heart rate variability (HRV) is a study of beat to beat variation in cardiac activity, which reflects the fluctuations in influence of sympathetic and parasympathetic divisions of ANS on the heart. Thus it is a simple, noninvasive tool to evaluate cardiac autonomic function.…”

Section: Introductionmentioning

confidence: 99%

Impact of obesity on cardiac autonomic functions in middle aged males

Shenoy¹,

Doreswamy²,

Shenoy³

et al. 2014

Natl J Physiol Pharm Pharmacol

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Background: Obesity and health hazards associated with it are leading cause of death worldwide. The incidents of obesity are also rising at an alarming rate in the urban Indian population. Obesity is associated with adverse cardiovascular events which could be due to the altered autonomic balance seen in these individuals. Heart rate variability (HRV) is a non-invasive economical tool to assess the autonomic function. Aims & Objective: The present study was undertaken to evaluate the effect of obesity on heart rate variability and to establish the relationship between BMI and HRV parameters. Materials and Methods: Forty six males in the age group of 40-55 years, who satisfied the inclusion and exclusion criteria, were included in the study. The subjects were divided into two groups as obese and non-obese based on their BMI as per WHO guidelines for Asian subjects. The ECG was recorded for a period of 10 minutes and frequency domain parameters of HRV were derived from it. Parameters obtained were compared between both the groups using independent 't' test and relationship between BMI and HRV parameters was established using Pearson's correlation test. P < 0.05 was considered as significant. Results: Obese individuals exhibited significantly lower values of both low and high frequency and normalized high frequency parameters. The ratio between low and high frequency and normalized low frequency parameters were significantly higher in obese group. A significant negative association was also observed between BMI and normalized high frequency parameter. Conclusion: A reduced parasympathetic activity associated with elevated sympathetic was observed in middle aged obese males in the resting state. This is suggestive of a higher risk for development of cardiovascular disorders.

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“…The sample size was calculated using the 30:15 ratio taken from a previous study done on obese children aged 5-10 years in India[29]. The similarity with the race and age group was considered for selecting values from the Indian study.…”

Section: Methodsmentioning

confidence: 99%

Autonomic functions and gastric motility in children with functional abdominal pain disorders

Karunanayake

Rajindrajith

Silva

et al. 2019

WJG

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BACKGROUNDAbdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs) are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood.AIMTo assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs.METHODSOne hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive techniques.RESULTSThe main gastric motility parameters assessed (gastric emptying rate [45.7 vs 59.6 in controls], amplitude [48.7 vs 58.2], frequency of antral contractions [8.3 vs 9.4], and antral motility index [4.1 vs 6.4]) were significantly lower in children with AP-FGIDs (P < 0.05). The post-prandial antral dilatation at 1 min after the test meal significantly correlated with the severity of abdominal pain (P < 0.05). Assessment of autonomic functions in AP-FGID patients showed neither a significant difference compared to the control group, nor a correlation with gastric motility abnormalities (P > 0.05). The duration of pain episodes negatively correlated with the parasympathetic tone (maladaptive parasympathetic tone) (P < 0.05).CONCLUSIONChildren with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction.

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Assessment of Autonomic Function Activity in Obese Children

Cited by 7 publications

References 13 publications

Effect of Body Mass Index on Cardiac Autonomic Functional Status in Healthy Young Adults

Effect of Body Mass Index on Cardiac Autonomic Functional Status in Healthy Young Adults

Impact of obesity on cardiac autonomic functions in middle aged males

Autonomic functions and gastric motility in children with functional abdominal pain disorders

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