This research presents atmospheric temperature profiles and trends retrieved using COSMIC RO technique and balloon-borne radiosonde instrument in 2007 and a few cases during 2017. By effectively using ‘wet’ temperature product available at COSMIC Data Analysis and Archive Center (CDAAC) website, an analysis has been made to present temperature profiles and trends at various regions including, Indian, Taiwan and Japan. A one-to-one correspondence is, clearly, seen between temperature profiles retrieved with COSMIC RO and radiosonde instrument. But, few and dominant differences in temperature profiles are found below at an altitude of ~5 km and above around tropopause (~16-17 km). The dominant differences found at below ~5km could be due to the inhomogeneous distribution of humidity present, generally, at the tropical regions, whereas above the tropopause altitudes, differences might be due to the ionospheric residual correction as reported by other researchers. Further, temperature monthly trends at various regions show distinct characteristics including, a sharp temperature inversion up to tropopause altitude. In addition, it is also observed maximum temperatures (peaks) during the northern summer seasons (May, June, July, and August) and minimum temperatures (troughs) during the northern winter seasons (November, December, January, and February) near to the surface of the Earth. Interestingly, although it is generally observed that the tropopause altitude is located at ~ 16-17 km at various regions, a keen observation reveals that distinct seasonal and latitudinal variations can be witnessed. With this case study, it may be concluded that the COSMIC RO technique is able to provide very accurate measurement, which reiterates its importance as a powerful tool to explore the Earth’s atmosphere on the local and global scale.