Assessment of asymptomatic ischemic heart disease using stress myocardial perfusion imaging in patients with type 2 diabetes mellitus

Deepti, Siddharthan; Roy, Ambuj; Patel, Chetan; Tandon, Nikhil; Naik, Nitish; Singh, Sandeep; Sharma, Gautam; Bahl, Vinay K.

doi:10.1016/j.ihj.2018.08.023

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…Many techniques can be used to assess cardiac function, such as cardiovascular magnetic resonance T1 mapping [ 4 ], Tc-99 m MIBI gated single-photon emission-computed tomography myocardial perfusion imaging [ 5 ], tissue Doppler strain echocardiography [ 6 ], and two-dimensional speckle tracking echocardiography (2D-STE) [ 7 , 8 ]. However, these techniques all have limitations.…”

Section: Introductionmentioning

confidence: 99%

Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction

Wang

Huang

et al. 2022

Diabetol Metab Syndr

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Background The purpose of this study was to assess subclinical left ventricle (LV) myocardial dysfunction using global myocardial work (MW) in type 2 diabetes mellitus (T2DM) patients with preserved left ventricle ejection fraction (LVEF). Methods Sixty T2DM patients and 60 normal controls were enrolled in the study. Apical 4-, 3- and 2-chamber views were acquired by two-dimensional echocardiography. Peak systolic myocardial global longitudinal strain (GLS), global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and myocardial work efficiency (GWE) were determined by speckle-tracking echocardiography (STE). Results The GLS values in the T2DM patients were significantly lower than those in normal controls (p < 0.001). The GWW in T2DM patients was significantly greater than that in normal controls, while GWI, GCW and GWE was significantly lower (p < 0.001). Receiver operating characteristic (ROC) analysis showed there were no significant different difference between GWW, GWE and GLS in the area under the curves (AUCs). In T2DM patients, fasting plasma glucose was positively correlated with GWW but negatively correlated with GWE, and GLS was negatively correlated with GWI and GCW. Conclusion From the research, we found that global MW as new technique could detect the subclinical LV myocardial dysfunction and confirm that the impaired LV function in T2DM patients with preserved LV systolic function.

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Section: Introductionmentioning

confidence: 99%

Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction

Wang

Huang

et al. 2022

Diabetol Metab Syndr

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show abstract

“…A contemporary study performed in India found a treadmill test positive for SMI in 23.1% out of 338 asymptomatic T2DM subjects [57], while another Indian study that enrolled 97 T2DM observed that only 10% out of the asymptomatic patients showed evidence of SMI or silent MI at SPECT [58]. Finally, a small Saudi Arabian study evaluating 59 T2DM patients without history of CAD, but with multiple CV risk factors detected an abnormal scan in 37% of the patients who had undergone myocardial perfusion SPECT imaging [59].…”

Section: Epidemiology Of Smimentioning

confidence: 98%

Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies

Kreutzenberg

2021

Exploration of Medicine

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Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD represents a constant challenge for the diabetologist, who has to decide whether a patient could or could not be screened for this disease. In the present narrative review, several aspects of silent CAD are considered: the epidemiology of the disease, the associated risk factors, and main studies conducted, in the last 20 years, especially aimed to demonstrate the usefulness of the screening of silent CAD, to improve cardiovascular outcomes in type 2 diabetes.

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“…Evaluation of LV ESV provides added over LVEF alone for prediction of cardiac death [14]. Perfusion deficits are stronger predictors of MI occurrence than contractility impairments [14][15][16].…”

Section: Clinical and Research Value Of G-spect: Perfusion And Region...mentioning

confidence: 99%

Objective, observer-independent evaluation of myocardial perfusion and function: the role of SPECT

Szot¹,

Kwiecień²,

Tekieli³

et al. 2022

pwki

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The number of patients with coronary artery disease and ischaemic heart failure -and those with terminal heart failure -is increasing despite improvements in medical and interventional therapies of ischaemic heart disease -and, over the next decades, it is projected to continue to increase further. Observer-independent, reproducible imaging techniques play a fundamental role in objective evaluation of both conventional (such as surgical or percutaneous) myocardial revascularization and novel therapeutic approaches to reduce myocardial ischaemia, improve contractility and prevent adverse myocardial remodelling. To be applicable to clinical practice, the clinical study design and data should best be rooted in everyday clinical practice. Accurate and reproducible assessment of left ventricular ejection fraction, left ventricular volumes, myocardial perfusion and function is one of the most important objectives of cardiac imaging. Current techniques used both in clinical studies and in everyday clinical practice include 2-and 3-dimensional echocardiography, magnetic resonance imaging, single-photon emission computed tomography and positron emission tomography; each of these has its strengths and limitations. We review present evidence on the role of single-photon emission computed tomography as a technique that may offer, through being observer-independent, the most objective evaluation of evolution of left ventricular perfusion, volumes and ejection fraction.

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Assessment of asymptomatic ischemic heart disease using stress myocardial perfusion imaging in patients with type 2 diabetes mellitus

Cited by 7 publications

References 12 publications

Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction

Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction

Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies

Objective, observer-independent evaluation of myocardial perfusion and function: the role of SPECT

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