Assessment of association between the Pro12Ala polymorphism of PPAR-γ gene with the risk of obstetric complications

Ostafiichuk, S. O.

doi:10.14739/2310-1210.2019.5.179431

Cited by 2 publications

(6 citation statements)

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“…On the other hand, the peroxisome proliferator-activated γ-receptor ( PPAR γ) rs1801282 SNV and its relationship with GWG were analyzed in 97 Ukrainian [ 34 ] and 162 Turkish women [ 32 ]; the authors concluded that based on adjusted models, Ala carriers had a greater probability of undergoing excessive GWG. In addition, the TT genotype from endothelial nitric oxide synthase (eNOS) Glu298Asp SNV in the Ukrainian sample was related to an increment of 5 kg compared to the other genotypes (GT and GG) [ 33 ].…”

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confidence: 99%

“…This hypothesis has been inconsistent with other studies. The effect of this SNV could be affected by race; for example, in 97 Caucasian Ukrainian women, the genetic variant of PPAR-γ Pro12Ala was associated with greater GWG and a high frequency of excessive GWG [ 34 ].…”

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confidence: 99%

“…As previously mentioned, the eNOS TT single-nucleotide variant is related to greater levels of triglycerides, cholesterol and low-density lipoprotein, glucose, and insulin and with greater HOMA-IR scores when compared with the GT genotype during the third trimester due to decreased activity of eNOS , particularly among those with excessive GWG [ 33 ]. It is possible that the activity of the PPAR-γ gene toward lipids and carbohydrate metabolism could have a positive association with GWG [ 34 ].…”

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confidence: 99%

“…The association between specific genetic variants and excessive GWG has been evaluated in 6974 women. The most recent studies came from the United States of America [17,[21][22][23][24], Brazil [25][26][27][28], Romania [29,30], Turkey [31,32], Ukraine [33,34], Canada [35], Germany [36], China [37], and Poland [38]. These studies were performed on pregnant adult women (aged [22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Relevant Sections 21 What Is the Role Of Genomic Sciences In...mentioning

confidence: 99%

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Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

IJMS

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Excessive or insufficient gestational weight gain (GWG) leads to diverse adverse maternal and neonatal outcomes. There is evidence that pregestational body mass index (pBMI) plays a role in GWG, but no genetic cause has been identified. In this review, we aim to analyze genotype variants associated with GWG. Results: We identified seven genotype variants that may be involved in GWG regulation that were analyzed in studies carried out in Brazil, Romania, the USA, Turkey, Ukraine, and Canada. Some genetic variants were only associated with GWG in certain races or depending on the pBMI. In women who were obese or overweight before gestation, some genetic variants were associated with GWG. Environmental and genetic factors together showed a greater association with GWG than genetic factors alone; for example, type of diet was observed to have a significant influence. Conclusions: We found little scientific evidence of an association between genotype variants in countries with a high prevalence of women of reproductive age who are overweight and obese, such as in Latin America. GWG may be more dependent on environmental factors than genetic variants. We suggest a deeper study of genetic variants, cytokines, and their possible association with GWG, always with the respective control of potential cofounding factors, such as pBMI, diet, and race.

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confidence: 99%

Section: Relevant Sectionsmentioning

confidence: 99%

Section: Relevant Sectionsmentioning

confidence: 99%

Section: Relevant Sections 21 What Is the Role Of Genomic Sciences In...mentioning

confidence: 99%

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Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

IJMS

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“…Основні етіологічні чинники надмірного блювання вагітних залишаються невідомими, проте попередні дослідження показали роль генетичних факторів і факторів зовнішнього середовища, що сприяють реалізації генетичної схильності [7,3]. Існує однозначна думка, що ХГЛ є важливим регулятором диференціації трофобластів і міграції клітин ворсинчастого цитотрофобласта в стінки спіральних артерій плацентарного ложа для створення прямого контакту між хоріоном плода й материнським кровотоком.…”

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Association of hyperemesis gravidarum with the risk of development of small for gestational age fetus

et al. 2022

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The goal of this study was to determine the association of hyperemesis gravidarum with the risk of development small for of fetus gestational age (SGA). Materials and methods. There were studied 327 pregnant women. The main group included 218 women with hyperemesis gravidarum, who were divided into two groups: 140 patients who were first hospitalized with hyperemesis gravidarum in the first trimester (up to 12 weeks of pregnancy) and 78 - who were first hospitalized with hyperemesis gravidarum in the second trimester (12-21 weeks of pregnancy). 109 pregnant women without vomiting were at control group. The diagnosis of SGA fetus was established on the basis of standard ultrasonic fetometry on the ALOKA SSD-1700. Determination of human serum chorionic gonadotropin (HCG) levels was performed at 15-20 weeks and was evaluated as MoM. The results were statistically analyzed using Statistica 10 (Serial Number: STA999K347150-W) and MEDCALC®. Results. In the main group, the SGA fetus was 3.4-fold more frequent compared with pregnant women in the control group (9.6% vs. 2.8%, p<0.05; OR=3.77; 95%CI:1,10-12.92). It was found that hyperemesis gravidarum in the first trimester does not affect the deviation of fetal weight deviations (p>0.05). However, hyperemesis gravidarum in pregnant women in the second trimester increases the risk of developing SGA fetus (OR=6.42; 95%CI 1.75-23.62; p<0.01) compared with control. Pregnant women with HCG≥2.5 MoM were 3.0-fold more likely to be diagnosed SGA fetus than with HCG<2.5 MoM (75.0% vs. 25.0%, p<0.001; OR=9.00; 95%CI:1.42-57.12) and 2.3-fold compared with the development of the normal fetus (75.0% vs. 33.3%, p<0.001; OR=6.00; 95%CI:1.47-24,4). Conclusion. Hyperemesis gravidarum in the second trimester of pregnancy and elevation of HCG level in the second trimester (≥2,5 МоМ) can be seen as markers of placental disfunction and high risk for SGA fetus.

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Assessment of association between the Pro12Ala polymorphism of PPAR-γ gene with the risk of obstetric complications

Cited by 2 publications

References 1 publication

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Association of hyperemesis gravidarum with the risk of development of small for gestational age fetus

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