Assessment of arterial stiffness in chronic obstructive pulmonary disease by a novel method: cardio-ankle vascular index

Aykan, Ahmet Çağrı; Gökdeniz, Tayyar; Gül, İlker; Boyacı, Faruk; Kalaycıoğlu, Ezgi; Hatem, Engin; Turhan, Turan; Ayyildiz, Fatih Alper; Aykan, Duygun Altıntaş; Çelik, Selman

doi:10.1093/eurheartj/eht310.p5080

Cited by 7 publications

(10 citation statements)

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“…The early detection of subclinical LVSD has been emphasized to be important in the prevention of heart failure by allowing medical treatment [33,34]. One cause of LVSD is RV dysfunction in COPD, while another is increased arterial rigidity [35,36]. In a third mechanism, the angiotensinconverting enzyme is present in very high concentrations in the lungs, and chronic hypoxemia activates the renin-angiotensin system, which, in turn, may play a role in the pathogenesis of LVSD [37].…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic evaluation of right and left heart findings according to the severity of the disease in stable chronic obstructive pulmonary disease

Mutlu¹,

Akşıt²,

N³

2018

biomedicalresearch

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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is seen alongside some systemic diseases that result in impaired functional capacity, worsening dyspnea, decreased health-related quality of life and increased mortality. Cardiovascular diseases, considering their effect on mortality, play an important role in such diseases. Objective: The aim of this study to evaluate the cardiac changes that develop secondary to COPD and attempt to identify any correlation between the severities of the disease determined using GOLD guidelines and ECHO findings. Method: This prospective study involved 32 male patients who presented to the pulmonary disease outpatient clinic with stable COPD. We compared the severity of COPD with the ECO findings of the patients. Findings: Correlations were found between the severity of COPD and heart rate, the number of cigarettes smoked and the respiratory function test results. Measurable tricuspid regurgitation was detected in 26 patients (26/32=81.2%), and the degree of tricuspid regurgitation according to the severity of COPD. Conclusion: We suggest that cardiac influences should be diagnosed early in the course of the disease, and that treatment be started to decrease the rates of mortality and morbidity in patients with COPD.

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Section: Discussionmentioning

confidence: 99%

Echocardiographic evaluation of right and left heart findings according to the severity of the disease in stable chronic obstructive pulmonary disease

Mutlu¹,

Akşıt²,

N³

2018

biomedicalresearch

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“…Furthermore, CAVI appropriately shows arterial stiffness in elder patients but augmentation index is suboptimal method for the evaluation of arterial stiffness in elder patients as it shows a plateau with age. 15,17 However, AAA is common among elder hypertensive males.…”

Section: Discussionmentioning

confidence: 99%

“…2 CAVI is related to, atherosclerosis, coronary syndrome-x, epicardial fat thickness, dipping status, chronic obstructive lung disease, silent neuronal injury, chronic venous insufficiency and deep vein thrombosis. 17,26–30 Vascular tree is a whole structure and segmental evaluations may cause misinterpretations. Coronary artery disease is prevalent in patients with peripheral artery disease and vice versa.…”

Section: Discussionmentioning

confidence: 99%

Assessment of cardio-ankle vascular index in patients with abdominal aortic aneurysm: An observational study

et al. 2020

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Objectives Arterial stiffness is associated with major adverse cardiovascular events. The aim of this study is to investigate arterial stiffness by cardio-ankle vascular index (CAVI) in patients with abdominal aortic aneurysm (AAA). Methods This observational and cross-sectional study involved 59 subjects with AAA and 32 healthy subjects. All subjects underwent ultrasonography examination. CAVI was measured by VaSera-1000 CAVI instrument. Results Mean abdominal aortic diameter of AAA patients and controls were 43.88 ± 9.28 mm and 20.43 ± 3.14 mm, consecutively. Baseline clinical characteristics of the patients and controls were similar for age, presence of hypertension, diabetes, dyslipidemia, coronary artery disease and smoking. Left ventricle ejection fraction and Left ventricle mass index (LVMI) were similar between groups. CAVI was significantly higher in patients with AAA than controls (9.74 ± 1.50 vs. 7.60 ± 1.07, p < 0.001). CAVI was positively correlated with AAA diameter ( r = 0.461, p < 0.001) and negatively correlated with left ventricle ejection fraction ( r= –0.254, p = 0.015). CAVI >8.3 had a sensitivity 89.8% and a specificity of 78.1% for predicting the presence of AAA in ROC analysis (area under curve = 0.897, 95%CI = 0.816–0.951, p < 0.001). Conclusion CAVI is increased in patients with AAA. Increased arterial stiffness may be a mechanical link between AAA, coronary artery disease and peripheral artery disease or a common mechanism effects the arterial stiffness, coronary artery disease, peripheral artery disease and AAA. Therefore, CAVI may be used as a valuable marker for risk stratification for the development of AAA in susceptible patients.

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“…CAVI is associated with epicardial fat thickness, atherosclerosis, chronic obstructive lung disease, coronary syndrome-x, dipping status, silent neuronal injury, diabetes, aging, chronic renal failure, dyslipidemia, smoking, hypertension, and obstructive sleep apnea. [14][15][16][17][18][19] Additionally, vasoactive medications including alpha-blockers, betablockers, angiotensin-converting enzyme inhibitors also alter CAVI. 19 None of our patient used antihypertensive medications in this study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of arterial stiffness in patients with venous thromboembolism: Separate or continuous circuits?

Aykan¹,

Hatem²,

Kalaycıoğlu³

et al. 2016

Phlebology

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Objectives The aim of this study is to evaluate the association of venous thromboembolism with arterial stiffness by cardio-ankle vascular index method. Method We included 52 patients with a documented lower extremity venous thromboembolism within the last six months and 52 healthy subjects to this cross sectional observational study. Results Cardio-ankle vascular index (8.58 ± 1.60 versus 7.05 ± 1.44, p < 0.001, respectively) and systolic blood pressure (128.02 ± 7.13 mmHg versus 123.94 ± 8.12 mmHg, p = 0.008, respectively) were significantly higher among patients with venous thromboembolism than controls. Cardio-ankle vascular index was an independent predictor of venous thromboembolism in multivariate logistic regression analysis (p < 0.001, odds ratio = 1.864, 95% confidence interval = 1.370-2.536). Cardio-ankle vascular index value > 7.8 had a sensitivity of 82.7% and a specificity of 80.8% for predicting venous thromboembolism (area under curve = 0.789, 95% confidence interval = 0.698-0.863, p < 0.001) in receiver operating characteristic curve analysis. Conclusion We found that arterial stiffness was increased in patients with venous thromboembolism which highlights the fact that arterial and venous circulation is in continuum and an insult may affect both of these circuits.

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Assessment of arterial stiffness in chronic obstructive pulmonary disease by a novel method: cardio-ankle vascular index

Cited by 7 publications

References 0 publications

Echocardiographic evaluation of right and left heart findings according to the severity of the disease in stable chronic obstructive pulmonary disease

Echocardiographic evaluation of right and left heart findings according to the severity of the disease in stable chronic obstructive pulmonary disease

Assessment of cardio-ankle vascular index in patients with abdominal aortic aneurysm: An observational study

Assessment of arterial stiffness in patients with venous thromboembolism: Separate or continuous circuits?

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