Assessment of Antiphospholipid Antibodies, CD4 Count and Some Haematological Parameters in HIV Patients attending a Tertiary Health Institution in South-Western Nigeria

Olusola, Olayanju Ayodeji; Temitope, Afolabi; Ezigbo, Eyiuche D.; Samson, Enitan Seyi; Olatundun, Oluwatayo Beatrice

doi:10.9734/ibrr/2018/41710

Cited by 2 publications

(1 citation statement)

References 33 publications

(43 reference statements)

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“…However, when test results is discordant, a third kit, which is the Tie breaker, 1/2 Stat Pak (Chembio Diagnostic Systems, New York, USA) was used. The HIV serostatus of the patient was taken as the result of either of the first two kits that agree with that of the third kit [20,21].…”

Section: Laboratory Analyses Hiv Detectionmentioning

confidence: 99%

Detection of Syphilis among HIV-Positive and HIV-Negative Patients in Ogun State, Nigeria

SS¹

2021

AII

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Background: Syphilis is still one of the major causes of death in some developing countries where HIV infection is also prevalent. The aim of this study was to determine the prevalence of syphilis among HIV positive and negative women in Ogun state. Methods: The serum samples of 240 (120 HIV Positive and 120 HIV Negative) consenting female participants were collected randomly and screened using two brands of Syphilis Immunochromatographic rapid diagnostic test (RDT) kits: LabAcon (Biotest Biotech Co., Ltd., Hangzhou, China) and Perfect (Abbon Health care, Ltd, UK). The demographic and clinical information of the participants were collected using a structured questionnaire. Statistical analysis was carried out using SPSS Statistics software package (version 18.0). One-way analysis of variance (ANOVA) and Tukey-Kramer Multiple Comparisons Test was used to test for significant differences in the prevalence of syphilis among the study population. P values <0.05 was considered significant. Results: The outcome of the study shows that Syphilis exist among both HIV-positive and HIV-negative women in Ogun State with a prevalence rate of 11.7% and 4.2%, respectively using LabAcon RDT kit and also 9.2% and 2.5%, respectively, using Perfect RDT kit. The occurrence of syphilis was significantly (P<0.05) higher among HIV-positive subjects compared to their 2 Annals of Immunology & Immunotherapy Enitan SS, et al. Detection of Syphilis among HIV-Positive and HIV-Negative Patients in Ogun State, Nigeria. Ann Immunol Immunother 2021, 3(2): 000144. Copyright© Enitan SS, et al. HIV-negative counterparts. All the participants who tested positive to syphilis were symptomatic regardless of their HIV status. Significant risk factors of syphilis associated with HIV infected subjects include past history of sexually transmitted infection and engagement in unprotected sex (p<0.05). Conclusion: Syphilis exists among both HIV-positive and HIV-negative women in Ogun State and therefore the need for routine screening for syphilis among women, especially those infected with HIV cannot be over-emphasized.

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Section: Laboratory Analyses Hiv Detectionmentioning

confidence: 99%

Detection of Syphilis among HIV-Positive and HIV-Negative Patients in Ogun State, Nigeria

SS¹

2021

AII

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Detection of Hepatitis B Virus Serological markers among Adult HIV Positive Female Patients on HAART in Ogun State, Nigeria

Enitan

2022

Preprint

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Hepatitis B virus (HBV) infection is endemic in sub-Saharan Africa, Nigeria inclusive, and it is common among HIV/AIDS patients. The aim of this study is to determine the prevalence of hepatitis B virus serological markers and associated risk factors among HIV-positive female patients on HAART in Ogun State, Nigeria. After receiving ethical permission from the Babcock University Health Research Ethics Committee (BUHREC), 100 female HIV-infected patients from Babcock University Teaching Hospital (BUTH), Ilishan-Remo, Ogun State, and General Hospital, Ijebu-Ode, Ogun State, were recruited for the study. The patients' HIV status was confirmed using three rapid diagnostic kits, all of which were used according to the manufacturer's instructions: Determine (Abbott Laboratories, Tokyo, Japan), Unigold HIV (Trinity Biotech Plc Bray, Co. Wicklow, Ireland), and 1/2 Stat Pak (Abbott Laboratories, Tokyo, Japan) (Chembio Diagnostic Systems, New York, USA). While an HBV 5-in-1 Panel supplied by Innovation Biotechnology Co., Ltd, Beijing, China was used for the qualitative detection of HBV markers in serum specimens. Out of the 100 study participants examined, 4(3.6%) were positive for HBsAg, 2 (1.8%) were positive for HBsAb, 81 (73.6%) were positive for HBeAg, 3 (2.7%) were positive for HBeAb, while 65 (59.1%) were positive for HBcAb. There was no significant association between the occurrences of HBsAg and HBsAb and the socio-demographic characteristics of the study participants (P>0.05), except for HBeAg and HBeAb (P<0.05). Identified risk factors include: lack of knowledge of HBV, lack of a history of HBV vaccination, history of blood transfusion, organ transplant, and unprotected sex among others. The findings demonstrate that Hepatitis B Virus (HBV) infection exists among HIV-positive female patients on HAART in Ogun State, Nigeria, particularly among the age categories of 18-25 years and 26-30 years. This necessitates ongoing and persistent public health interventions among the study population.

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Assessment of Antiphospholipid Antibodies, CD4 Count and Some Haematological Parameters in HIV Patients attending a Tertiary Health Institution in South-Western Nigeria

Cited by 2 publications

References 33 publications

Detection of Syphilis among HIV-Positive and HIV-Negative Patients in Ogun State, Nigeria

Detection of Syphilis among HIV-Positive and HIV-Negative Patients in Ogun State, Nigeria

Detection of Hepatitis B Virus Serological markers among Adult HIV Positive Female Patients on HAART in Ogun State, Nigeria

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