Assessment of Antioxidant and Cytotoxic Activity of Known Antioxidants Compared to Neopterin

Girgin, Gözde; Sabuncuoğlu, Suna; Ünal, Ayşe Zeynep; Baydar, Terken

doi:10.3390/proceedings1101071

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, antioxidants, like vitamins C, D and E may attenuate Covid-19 severity through modulation of glutathione level, immune response and tissue oxygenations [ 48 ]. It has been documented that NPT and 7,8-dihydro-NPT have antioxidant effects comparable to that of melatonin [ 49 ]. Similarly, high NPT level reflects a poor endogenous antioxidant capacity and deregulated immune response [ 50 ]; herein, NPT may attenuate Covid-19-associated inflammatory and OS-derived disorders as well as tissue damage (Fig.…”

Section: Role Of Neopterin In Covid-19mentioning

confidence: 99%

The potential role of neopterin in Covid-19: a new perspective

et al. 2021

View full text Add to dashboard Cite

Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-γ). NPT is regarded as a macrophage stimulation indicator, marker of cellular immune activation and T helper 1 (Th1) type 1 immune response. Here, we aimed to provide a view point on the NPT features and role in Covid-19. Serum NPT level is regarded as an independent prognostic factor for Covid-19 severity, with levels starting to increase from the 3rd day of SARS-CoV-2 infection, being associated with severe dyspnea, longer hospitalization period and complications. Also, early raise of NPT reflects monocytes/macrophages activation before antibody immune response, despite the NPT level may also remain high in Covid-19 patients or at the end of incubation period before the onset of clinical symptoms. On the other hand , NPT attenuates the activity of macrophage foam cells and is linked to endothelial inflammation through inhibition of adhesion molecules and monocytes migration. However, NPT also exerts anti-inflammatory and antioxidant effects by suppressing NF-κB signaling and NLRP3 inflammasomes. NPT can be viewed as a protective compensatory mechanism to counterpoise hyper-inflammation, oxidative stress, and associated organ damage.

show abstract

Section: Role Of Neopterin In Covid-19mentioning

confidence: 99%

The potential role of neopterin in Covid-19: a new perspective

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The effects of neopterin are not yet fully elucidated. Still, studies indicated a link between neopterin and oxidative stress, with the formation of reactive oxygen species [ 12 ] known to play an essential role in the initiation, proliferation, and development of cancer cells by maintaining their survival [ 13 ]. The serum values of neopterin showed limited performance as a marker for CRC compared to CEA (CarcinoEmbryonic Antigen), TPA (tissue plasminogen activator), and CA 19/9 (cancer antigen 19-9) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer

Ciocan

Hajjar

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Chronic inflammation is demonstrated to play a direct role in carcinogenesis. Our exploratory study aimed to assess the potential added value of two inflammation biomarkers, chitotriosidase and neopterin, in follow-up evaluation of patients with colorectal cancer (CRC). An observational exploratory study was conducted. Patients with CRC and matched controls (1:1, age, sex, and living environment) were evaluated. The patients with CRC (CRC group) and controls were assessed at baseline (before surgical intervention for patients with CRC). Patients with CRC were also evaluated at 1-year follow-up. Significantly more patients with blood group A (54.5% vs. 25.0%) and smokers (50.0% vs. 22.7%) were in the CRC group. The serum values of chitotriosidase and neopterin were higher in CRC patients than in controls, but only neopterin reached the conventional level of statistical significance (p-value = 0.015). The circulating chitotriosidase and neopterin values decreased significantly at 1-year follow-up (p-value < 0.0001). Patients with higher N- and M-stage showed statistically significant higher levels of chitotriosidase and neopterin at baseline and 1-year follow-up (p-values < 0.03). Circulating chitotriosidase levels also showed statistically significant differences regarding baseline and 1-year follow-up on patients with CRC and different differentiation grades (p-values < 0.02). The circulating levels of neopterin significantly decreased at 1-year follow-up, indicating its potential as a prognostic marker. The circulating values of chitotriosidase and neopterin exhibit significant differences in patients with than without recurrences. Our results support further evaluation of chitotriosidase and neopterin as prognostic markers in patients with CRC.

show abstract