Assessment of antioxidant activity of pure graphene oxide (GO) and composite V2O5/GO using DPPH radical and H2O2 scavenging assays

Sadiq, Huma; Sadiq, Hanan; Sohail, Amir; Basit, Abdul; Akhtar, Naseem; Batool, Kiran; Hisaindee, Soleiman; Asghar, Lubna

doi:10.1007/s10971-023-06231-6

Cited by 10 publications

(3 citation statements)

References 64 publications

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“…The DPPH • assay, reliant on the stable free radical 2,2-diphenyl-1-picrylhydrazyl, offers an efficient method for assessing antioxidant activity . This stable radical, characterized by an unpaired valence electron at a nitrogen bridge, imparts a violet hue to its ethanol solution.…”

Section: Resultsmentioning

confidence: 99%

“…The DPPH • assay, reliant on the stable free radical 2,2-diphenyl-1-picrylhydrazyl, offers an efficient method for assessing antioxidant activity. 35 This stable radical, characterized by an unpaired valence electron at a nitrogen bridge, imparts a violet hue to its ethanol solution. Upon interacting with an antioxidant, DPPH • free radicals undergo reduction, resulting in the formation of yellow diphenylpicrylhydrazine.…”

Section: Dpphmentioning

confidence: 99%

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Evaluation of Free Radical Scavenging Ability of Triazole-3-Thiol: A Combination of Experimental and Theoretical Approaches

Quy Huong,

Nam,

Quang

et al. 2024

ACS Omega

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An assessment of the free radical scavenging potential of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol (AT) and 4-amino-5-(4-pyridyl)-4H-1,2,4-triazole-3-thiol (AP) involved a combination of experimental methodologies and theoretical calculations. In the 2,2-diphenyl-1-picrylhydrazyl (DPPH•) assay, AT exhibited an heightened efficacy in scavenging DPPH• radicals compared to AP. This was evidenced by the notably lower IC50DPPH value observed for AT (1.3 × 10–3 ± 0.2 × 10–3 M) in comparison to AP (2.2 × 10–3 ± 0.1 × 10–3 M). Similarly, in the 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS• +) test, AT exhibited superior ability in neutralizing ABTS•+ free radical cations compared to AP, with the computed IC50ABTS values of 4.7 × 10–5 ± 0.1 × 10–5 M for AT and 5.5 × 10–5 ± 0.2 × 10–5 M for AP. Density functional theory served as the tool for evaluating the correlation between structural attributes and the antioxidant efficacy of the studied molecules. The findings highlighted the flexibility of hydrogen atoms within NH and NH2 groups to nucleophilic attacks, indicative of their pivotal role in the scavenging mechanism. Furthermore, investigations into the interactions between AT and AP with the free radical HOO• revealed predominantly the reaction via the hydrogen atom transfer mechanism. Both experimental observations and theoretical deductions collectively affirmed AT’s superior free radical scavenging ability over AP in the gas phase and ethanol.

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Section: Resultsmentioning

confidence: 99%

Section: Dpphmentioning

confidence: 99%

Evaluation of Free Radical Scavenging Ability of Triazole-3-Thiol: A Combination of Experimental and Theoretical Approaches

Quy Huong,

Nam,

Quang

et al. 2024

ACS Omega

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“…no. materials synthesis methods biomedical applications ref1 x V 2 O 5 ·(100 – x ) [CaF 2 ·3P 2 O 5 ·CaO] glass system with 0 ≤ x ≤ 16 mol %melt-quenching techniqueinvitro studies of antitumor activity 2TiO 2 @V 2 O 5 self-assemblyantibacterial activity based on photosensitive properties 3V 2 O 5 /chitosan (CS) codoped tin oxide (SnO 2 ) quantum dots (QDs)coprecipitation techniqueantimicrobial activity 4V 2 O 5 /GO (Graphene oxide)coprecipitation methodantioxidant activity 5mesoporous carbon@V 2 O 5 (C@V)chemical methoddrug delivery, anticancer, antimicrobial and antioxidant activitypresent work…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials Based Multifunctional Bioactivities of V₂O₅ and Mesoporous Carbon@V₂O₅ Composite: Preparation and Characterization

Bhosale,

Dhavale

et al. 2024

Langmuir

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Nanocarriers have attracted considerable interest due to their prospective applications in the delivery of anticancer medications and their distinct bioactivities. Biogenic nanostructures can be effective nanocarriers for delivering drugs as a consequence of sustainable and biodegradable biomassderived nanostructures that perform specific functions. In this case, a vanadium oxide (V 2 O 5 ) and mesoporous carbon@V 2 O 5 (C@V) composite was developed as a possible drug delivery system, and its bioactivities, including antioxidant, antibacterial, and anticancer, were investigated. Doxorubicin (DOX), an anticancer drug, was introduced to the nanoparticles, and the loading and release investigation was conducted. Strong interfacial interactions between mesoporous carbon (MC) and V 2 O 5 nanostructures have been found to improve performance in drug loading and release studies and bioactivities. After incubation, the potent anticancer effectiveness was seen based on C@V nanocomposite. This sample was also utilized to research potential biomedical uses as an antioxidant, antibacterial, and anticancer. The most effective antioxidant, the C@V sample (61.2%), exhibited a higher antioxidant activity than the V-2 sample (44.61%). The C@V sample ultimately attained a high DOX loading efficacy of 88%, in comparison to a pure V 2 O 5 sample (V-2) loading efficacy of 80%. Due to the combination of mesoporous carbon and V 2 O 5 , which increases specific surface area and surface sites of action as well as the morphology, it proved that the mesoporous carbon@V 2 O 5 composite (C@V) sample demonstrated greater efficacy.

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Graphene Derivatives Functionalized Polycaprolactone/Gelatin Electrospun Nanofibrous Membrane Through Mussel-Inspired Polydopamine: Multifunctional Scaffold with High Potential for Nerve Tissue Engineering

Moghadam,

Avatefi,

Shavali

et al. 2024

J Polym Environ

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Assessment of antioxidant activity of pure graphene oxide (GO) and composite V2O5/GO using DPPH radical and H2O2 scavenging assays

Cited by 10 publications

References 64 publications

Evaluation of Free Radical Scavenging Ability of Triazole-3-Thiol: A Combination of Experimental and Theoretical Approaches

Evaluation of Free Radical Scavenging Ability of Triazole-3-Thiol: A Combination of Experimental and Theoretical Approaches

Nanomaterials Based Multifunctional Bioactivities of V₂O₅ and Mesoporous Carbon@V₂O₅ Composite: Preparation and Characterization

Graphene Derivatives Functionalized Polycaprolactone/Gelatin Electrospun Nanofibrous Membrane Through Mussel-Inspired Polydopamine: Multifunctional Scaffold with High Potential for Nerve Tissue Engineering

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Assessment of antioxidant activity of pure graphene oxide (GO) and composite V2O5/GO using DPPH radical and H2O2 scavenging assays

Cited by 10 publications

References 64 publications

Evaluation of Free Radical Scavenging Ability of Triazole-3-Thiol: A Combination of Experimental and Theoretical Approaches

Evaluation of Free Radical Scavenging Ability of Triazole-3-Thiol: A Combination of Experimental and Theoretical Approaches

Nanomaterials Based Multifunctional Bioactivities of V2O5 and Mesoporous Carbon@V2O5 Composite: Preparation and Characterization

Graphene Derivatives Functionalized Polycaprolactone/Gelatin Electrospun Nanofibrous Membrane Through Mussel-Inspired Polydopamine: Multifunctional Scaffold with High Potential for Nerve Tissue Engineering

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Nanomaterials Based Multifunctional Bioactivities of V₂O₅ and Mesoporous Carbon@V₂O₅ Composite: Preparation and Characterization