Assessment of Antioxidant Activity of Some Antileprotic Drugs

T, Kalpana; Karunakar, N; Reddy, Mada S.; Prabhakar, M. C.; Krishna, D. R.

doi:10.1055/s-0031-1300093

Cited by 4 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…Experimental and clinical studies on hypertension suggest that increased production of reactive oxygen species plays a role in its etiology [1], and epidemiological studies indicate that a dietary intake of ascorbic acid (CAS 50-81-7), an antioxidant [2,3], reduces the incidence of hypertension [4,5]. These findings suggest that ascorbic acid lowers blood pressure (BP) in patients with hypertension.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ascorbic Acid on Ambulatory Blood Pressure in Elderly Patients with Refractory Hypertension

Sato

Dohi

Kojima

et al. 2011

Arzneimittelforschung

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The increased production of reactive oxygen species plays a role in the etiology of hypertension, but the effects of antioxidants on blood pressure are controversial. However, antioxidants possibly lower blood pressure in elderly patients with hypertension, because vascular aging is also closely related to oxidative stress. Effects of chronic treatment with ascorbic acid (CAS 50-81-7; 600 mg/day for 6 months) on blood pressure and levels of C-reactive protein, 8-isoprostane, and malondialdehyde-modified low-density lipoproteins were examined in elderly patients (n = 12, six males/six females, age 78.3 +/- 5.0 years, mean +/- SD [range, 67 to 84 years]; elderly group) and adult patients (n = 12, five males/seven females, age 54.6 +/- 6.7 years [range, 39 to 621; adult group) with refractory hypertension. Chronic treatment with ascorbic acid markedly reduced systolic blood pressure and pulse pressure in ambulatory blood pressure monitoring in the elderly group (from 154.9 +/- 21.6 to 134.8 +/- 19.7 mmHg, p < 0.001; and from 79.1 +/- 22.1 to 63.4 +/- 18.7, p < 0.05; respectively), which was accompanied by an increase in the serum levels of ascorbic acid and decreases in the levels of C-reactive protein, 8-isoprostane, and malondialdehyde-modified low-density lipoproteins. In contrast, ascorbic acid did not affect blood pressure in the adult group. These results suggest that ascorbic acid is useful for controlling blood pressure in elderly patients with refractory hypertension.

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Section: Introductionmentioning

confidence: 99%

Effects of Ascorbic Acid on Ambulatory Blood Pressure in Elderly Patients with Refractory Hypertension

Sato

Dohi

Kojima

et al. 2011

Arzneimittelforschung

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“…The results showed that in the presence of rifampicin, the concentration of DPPH peaks decreased depending on the concentration. Furthermore, the free radical scavenging activity of rifampicin is measured by Kalpana et al [ 15 ] and ascorbic acid was used for comparison. Although the above-mentioned researchers used different procedures, the results of this work are consistent with the available literature.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity of Pharmaceuticals: Predictive QSAR Modeling for Potential Therapeutic Strategy

et al. 2022

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Since oxidative stress has been linked to several pathological conditions and diseases, drugs with additional antioxidant activity can be beneficial in the treatment of these diseases. Therefore, this study takes a new look at the antioxidant activity of frequently prescribed drugs using the HPLC-DPPH method. The antioxidative activity expressed as the TEAC value of 82 drugs was successfully determined and is discussed in this work. Using the obtained values, the QSAR model was developed to predict the TEAC based on the selected molecular descriptors. The results of QSAR modeling showed that four- and seven-variable models had the best potential for TEAC prediction. Looking at the statistical parameters of each model, the four-variable model was superior to seven-variable. The final model showed good predicting power (r = 0.927) considering the selected descriptors, implying that it can be used as a fast and economically acceptable evaluation of antioxidative activity. The advantage of such model is its ability to predict the antioxidative activity of a drug regardless of its structural diversity or therapeutic classification.

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Oxidative metabolic changes in pleural fluid of tuberculosis patients

Reddy

Doreswamy

Krishna

et al. 2008

Bangladesh J Pharmacol

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The pleural fluid was aspirated from the tuberculous patients both untreated and under treatment with three months anti-tuberculosis therapy. The amount of malondialdehyde, lactate dehydrogenase, and total protein content in pleural fluid of untreated tuberculous patients were found to be significantly higher when compared with under treatment group. The pleural fluid total anti-oxidant levels were significantly lower in untreated cases in comparison to under treatment. Decrease in the total anti-oxidant status was more pronounced in untreated cases, established that anti-oxidants were nearly completely utilized to scavenge the free radicals. Our findings further support the importance of anti-oxidants in the treatment of tuberculous patient.

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Assessment of Antioxidant Activity of Some Antileprotic Drugs

Cited by 4 publications

References 6 publications

Effects of Ascorbic Acid on Ambulatory Blood Pressure in Elderly Patients with Refractory Hypertension

Effects of Ascorbic Acid on Ambulatory Blood Pressure in Elderly Patients with Refractory Hypertension

Antioxidant Activity of Pharmaceuticals: Predictive QSAR Modeling for Potential Therapeutic Strategy

Oxidative metabolic changes in pleural fluid of tuberculosis patients

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