Assessment of Antimicrobial, Anti-Inflammatory Activity and Docking Study of Novel 2-Arylimino-5-Indole-2-Yl-Methylidene-1, 3-Thiazolidine-4-one Derivatives

Abstract

A novel series of 2-(arylimino)-5-(indole-2-ylmethylidene)-1,3-thiazolidine-4-onederivatives were synthesized and screened for their anti-inflammatory and analgesic potential. The structures of newly synthesized compounds were confirmed by their analytical and spectroscopic data using IR and 1H-NMR. The novel compounds were evaluated for their anti-inflammatory potential using carrageenan induced paw edema model and analgesic activity using acetic acid induced abdominal writhing test. Three compounds 4g,4m and 4o alleviated inflammation more than the standard drug Diclofenac Sodium. The synthesized compounds also showed significant analgesic activity. Insilicomoleculardocking studies of the synthesized compounds were done on crystal structure of Cyclooxygenase-2using Glide version 5.0 following the standard procedure recommended by Schrodinger to study their observed activity, which revealed a significant correlation between the binding score and biological activity for these compounds. Maximum Glide score was obtained for compound 4o having a value of-7.42. This compound showed one interaction with the enzyme.