Assessment of Antifungal Potential of Aqueous and Methanol Extracts of Cassia alata

Alalor, Christian Arerusuoghene; Igwilo, C. I.; Jeroh, E.

doi:10.3923/ajbs.2012.120.125

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Many researchers [17,18,19] supported the results of crude methanol extract of C. alata as obtained in this study to be effective against dermatophytes.…”

Section: Resultssupporting

confidence: 65%

In vitro Anti-dermatophyte Activities of Crude Extracts of Cassia alata

Ekwealor

Oyeka

2015

EJMP

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“…Many researchers [17,18,19] supported the results of crude methanol extract of C. alata as obtained in this study to be effective against dermatophytes.…”

Section: Resultssupporting

confidence: 65%

In vitro Anti-dermatophyte Activities of Crude Extracts of Cassia alata

Ekwealor

Oyeka

2015

EJMP

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“…Invasion by bacteria, loss of nutrition, neither metabolic control and diminished mechanical environment around the wound site makes it difficult to healing [5]. Traditional treatments involve the use of herbal extracted compounds [6], animal derived bio-actives [7], maggot therapy [8], hirudotherapy [9], silver [10], herbal based ointments [11] and many traditional wound dressings. Medicinal plant extracts when utilized in the form of ointment and hydrogel have many disadvantages such as drying up quickly on exposure to air and softening the surrounding healthy tissue making it unsuitable for exudating wounds [12,13].…”

Section: Introductionmentioning

confidence: 99%

Strategically designed SPEEK nanofibrous scaffold with tailored delivery of resveratrol for skin wound regeneration

Ekambaram¹,

Saravanan²,

Dharmalingam³

2022

Biomed. Phys. Eng. Express

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Electro-spinnable polymeric materials can easily form two-dimensional (2D) nanofibrous scaffolds improving biochemical functionalities specially in the area of skin wound healing and nanomedicine, but it has been hard to achieve this on a highly mechanically stable biopolymer, Poly ether ether ketone (PEEK), due to its intrinsic hydrophobicity and chemical inertness. Herein, we demonstrated a novel nanomedicine healing system consisting of sulphonated poly ether ether ketone combined with resveratrol (SPEEK+RSV), which could act as an effective 2D nano bio-material in vitro and in vivo, without observable cytotoxicity. The fabricated nanocomposites exhibited enriched skin cell proliferation and adhesion as confirmed from the results of MTT, cell adhesion and live-dead assay. Results of SEM analysis showed a uniform nano-sized distribution with adequate pore size and porosity % facilitating a desired breathable environment at the wound site. The results of FT-IR, tensile studies and TGA analyses confirmed the presence of appropriate bonds and improved mechanical stability of the RSV incorporated nanofibrous scaffold. Results of anti-microbial analysis portrayed good potentiality of the fabricated nanofibers in treating wounds colonized with bacterial infections. Controlled drug release of resveratrol established the bio-compatibility of the nanofibers in skin wound regeneration. In vivo analysis assessed in female Wistar rats enabled complete wound closure with 100 % wound contraction within 16 days. Results of histopathology analysis through H-E and MT staining presented the re-surfing of the wound environment with regeneration of epithelium, granulation tissue and collagen. Thus, the fabricated 2D nanofibrous scaffold incorporated with pharmaceutical RSV bio-medicine perceptively mimicked skin ECM convincingly aiding the progression of skin wound regeneration mechanism.

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“…Several studies have been done to provide scientific basis for the efficacy of plants in phytomedicine. Alalor et al [9] reported that the aqueous and methanol extracts of cassia alata has powerful antifungal properties against Candida albicans, Trichophyton mentagroph yte, Aspergillusiger and Penicillium. They conclu ded that the in vitro findings justified the use of the extracts of C. alata in traditional medicine practice for the treatment of some external and fungal infections.…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Antidermatophyte Creams Formulated from Ethanol Extracts of Cassia Occidentalis and Cassia Alata Leaves

Oyedeji

Fawehinmi²,

Etatuvie³

et al. 2021

ARRB

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Incidence of drug resistance by dermatophytes is a worldwide concern. Researchers search for natural and better drugs to arrest the ugly situation. This study aims to formulate antidermatophyte Creams with ethanol extracts of the leaves of cassia alata and cassia occidentalis against four selected dermatophytes namely Trichophyton mentagrophtes, Microsporum audounii, Epidermophyton floccosum and Malassezia furfur. Wistar rats were used in determining the efficacy of the formulated herbal creams by examining the biopsies of the skin of the infected rats for presence of fungal hyphae, tissue destruction, Inflammation of the skin, absence of sebaceous gland and also absence of hair follicles. Dekeratinization of the skin layer was also measured. From the result obtained, it was observed that the efficacy of the creams is concentration dependent. Cassia alata cream formulation was particularly effective against three of the dermatophytes namelyTrichophyton mentagrophtes (30.71± 0.51 µm) Microsporum audounii (36.17± 0.59 µm), and Epidermophyton floccosum (37.49± 0.18 µm) while Cassia occidentalis cream was effective against Malassezia furfur (33.22± 0.16 µm). The results showed that the plants ethanol extracts can be utilized in the management of dermatophytosis when formulated as a cream for topical use.

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Assessment of Antifungal Potential of Aqueous and Methanol Extracts of Cassia alata

Cited by 6 publications

References 8 publications

In vitro Anti-dermatophyte Activities of Crude Extracts of Cassia alata

In vitro Anti-dermatophyte Activities of Crude Extracts of Cassia alata

Strategically designed SPEEK nanofibrous scaffold with tailored delivery of resveratrol for skin wound regeneration

Comparative Efficacy of Antidermatophyte Creams Formulated from Ethanol Extracts of Cassia Occidentalis and Cassia Alata Leaves

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