Assessment of antidepressant and anxiolytic properties of NK1 antagonists and Substance P in Wistar Kyoto rats

Malkesman, Oz; Braw, Yoram; Weller, Aron

doi:10.1016/j.physbeh.2006.11.014

Cited by 20 publications

(14 citation statements)

References 61 publications

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“…Preclinical trials have supported the idea that NK1 receptor antagonism might have useful antidepressant effects in several animal models of depression (Ebner and Singewald 2006), for example in the forced swim test (Dableh et al 2005;Malkesman et al 2007). Consistent with preclinical evidence, early clinical trials also suggested antidepressant effects in response to NK1 receptor antagonism.…”

Section: Introductionmentioning

confidence: 83%

Short-term NK1 receptor antagonism and emotional processing in healthy volunteers

et al. 2010

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These results suggest that NK1 receptor antagonism does affect some aspects of emotional processing and, in particular, that it has anxiolytic-like effects. The profile of effects reported here is, however, more limited than that found in response to conventional antidepressant treatment, and this may explain disappointing results at clinical trial. Healthy volunteer models of emotional processing may be useful in closing the gap between preclinical and clinical trials.

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Section: Introductionmentioning

confidence: 83%

Short-term NK1 receptor antagonism and emotional processing in healthy volunteers

et al. 2010

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“…Rats were filmed at day 10 after surgery, and again after AES treatment. After this they were filmed once a week throughout the month following the AES treatment (Janssen et al, 1960;Kazlauckas et al, 2005;Malkesman et al, 2007;Strekalova et al, 2004). …”

Section: Monitoring Depressive-like Behaviormentioning

confidence: 99%

Programmed Acute Electrical Stimulation of Ventral Tegmental Area Alleviates Depressive-Like Behavior

Friedman

Frankel

Flaumenhaft

et al. 2008

Neuropsychopharmacol

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Depressive disorders affect approximately 5% of the population in any given year. Antidepressants may require several weeks to produce their clinical effects. Despite progress being made in this area there is still room and a need to explore additional therapeutic modes to increase treatment effectiveness and responsiveness. Herein, we examined a new method for intervention in depressive states based on deep brain stimulation of the ventral tegmental area (VTA) as a source of incentive motivation and hedonia, in comparison to chemical antidepressants. The pattern of stimulation was fashioned to mimic the firing pattern of VTA neurons in the normal rat. Behavioral manifestations of depression were then monitored weekly using a battery of behavioral tests. The results suggest that treatment with programmed acute electrical stimulation of the VTA substantially alleviates depressive behavior, as compared to chemical antidepressants or electroconvulsive therapy, both in onset time and longitudinal effect. These results were also highly correlated with increases in brainderived neurotrophic factor mRNA levels in the prefrontal cortex.

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“…Several studies have demonstrated differing responses to antidepressants, deficits in reward behavior, and changes in hormonal levels in this strain. 20–22 …”

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confidence: 99%

An Evaluation of Neuroplasticity and Behavior After Deep Brain Stimulation of the Nucleus Accumbens in an Animal Model of Depression

et al. 2011

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BACKGROUND Recent interest has demonstrated the nucleus accumbens (NAcc) as a potential target for the treatment of depression with deep brain stimulation (DBS). OBJECTIVE To demonstrate that DBS of the NAcc is an effective treatment modality for depression and that chemical and structural changes associated with these behavioral changes are markers of neuroplasticity. METHODS A deep brain stimulator was placed in the NAcc of male Wistar-Kyoto rats. Groups were divided into sham (no stimulation), intermittent (3 h/d for 2 weeks), or continuous (constant stimulation for 2 weeks). Exploratory and anxietylike behaviors were evaluated with the open-field test before and after stimulation. Tissue samples of the prefrontal cortex (PFC) were processed with Western blot analysis of markers of noradrenergic activity that included the noradrenergic synthesizing enzyme tyrosine hydroxylase. Analysis of tissue levels for catecholamines was achieved with high-performance liquid chromatography. Morphological properties of cortical pyramidal neurons were assessed with Golgi-Cox staining. RESULTS Subjects undergoing intermittent and continuous stimulation of the NAcc exhibited an increase in exploratory behavior and reduced anxietylike behaviors. Tyrosine hydroxylase expression levels were decreased in the PFC after intermittent and continuous DBS, and dopamine and norepinephrine levels were decreased after continuous stimulation. Golgi-Cox staining indicated that DBS increased the length of apical and basilar dendrites in pyramidal neurons of the PFC. CONCLUSION Deep brain stimulation induces behavioral improvement in and neurochemical and morphological alterations of the PFC that demonstrate changes within the circuitry of the brain different from the target area of stimulation. This observed dendritic plasticity may underlie the therapeutic efficacy of this treatment.

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Assessment of antidepressant and anxiolytic properties of NK1 antagonists and Substance P in Wistar Kyoto rats

Cited by 20 publications

References 61 publications

Short-term NK1 receptor antagonism and emotional processing in healthy volunteers

Short-term NK1 receptor antagonism and emotional processing in healthy volunteers

Programmed Acute Electrical Stimulation of Ventral Tegmental Area Alleviates Depressive-Like Behavior

An Evaluation of Neuroplasticity and Behavior After Deep Brain Stimulation of the Nucleus Accumbens in an Animal Model of Depression

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