Assessment of anti‐inflammatory activity of <i>Poria cocos</i> in sodium lauryl sulphate‐induced irritant contact dermatitis

Fuchs, S.; Heinemann, Christian; Schliemann‐Willers, S.; Hartl, H; Fluhr, Joachim W.; Elsner, Peter

doi:10.1111/j.0909-752x.2006.00168.x

Cited by 36 publications

(28 citation statements)

References 20 publications

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“…Honey mixture appears useful in the control of dermatitis and psoriasis vulgaris (Al-Waili, 2003). The anti-inflammatory activity of Poria cocos in sodium lauryl sulfate-induced irritant contact dermatitis can be explained by phospholipase A2 (Fuchs et al, 2006). Iijima et al reported that Juzen-taiho-to including Poria cocos and Rehmannia glutinosa corrected the Th1/Th2 imbalance and decreased the elevation of IgE levels as well as the dermatitis in NC/Nga mice (Iijima et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of Kyungohkgo in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Ahn

Kim

et al. 2011

Arch. Pharm. Res.

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Kyungohkgo (KOG) is one of the most important formulas in traditional oriental medicine. We investigated the remedial effect of KOG on the development of atopic dermatitis (AD) in female NC/Nga mice. AD-like lesion was induced by the application of 2,4-Dinitrochlorobenzene on to the back skin repeatedly; KOG was administered orally (12.5 and 25.0 mg/kg) and topically (0.5 and 1.0 mg/mouse) to NC/Nga mice once a day for all through the period of this experiment and every mouse body weight was periodically taken. The effects of KOG on 2,4-Dinitrochlorobenzene-treated NC/Nga mice were determined by measuring AD-like skin lesions, the infiltration of mast cells and serum immunoglobulin E concentration. After the KOG applications are over, the KOG groups had less skin lesions than the atopy one, their immunoglobulin E levels were significantly downregulated and the infiltration of mast cells in the dorsal skin were reduced. Our results suggest that KOG may be effective in alleviating the development of AD. The inhibition of AD in NC/Nga mice may be influenced by the prevention of mast cell activation.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effect of Kyungohkgo in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Ahn

Kim

et al. 2011

Arch. Pharm. Res.

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“…However, the anti-inflammatory action was strongly attributed to its multiple components. Phytochemically, FBD-CO 2 was mainly composed of (i) essential oil from A. macrocephala, in which atractylenolide I, III and 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol, could inhibit lipopolysaccharideinduced TNF-␣ production, or acetic acid-induced vascular permeability (Li et al, 2007a,b), (ii) essential oil from A. sinensis in which butylphthalide was antagonistic to inflammatory response to brain I/R (Xu and Feng, 2000), and (iii) triterpenes from P. cocos, in which pachymic and dehydrotumulosic acids were potent inhibitors of phospholipase A2 and lipoxygenase (Kaminaga et al, 1996;Cuellar et al, 1997;Giner Larza et al, 2000;Fuchs et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Herbal formula FBD extracts prevented brain injury and inflammation induced by cerebral ischemia–reperfusion

Lin

Zhu

Yan

et al. 2008

Journal of Ethnopharmacology

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“…In particular, this fungus is widely used in traditional medicine to treat chronic gastritis, acute gastroenteric catarrh, gastric atony, oedema, nephrosis, dizziness, nausea, and emesis [16,17]. Many previous studies have indicated that its extracts and components have a variety of biological activities such as anti-fungal and anti-bacterial [18], antioxidant [19-21], neuroprotective [22], anti-hypertonic [23], anti-inflammatory [17,24-26], anti-angiogenic [27,28], and anti-cancer effects [29,30]. However, the claimed benefits and their action mechanisms are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages

Jeong

Lee

Han

et al. 2014

BMC Complement Altern Med

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BackgroundPoria cocos Wolf, a medicinal fungus, is widely used in traditional medicines in East Asian countries owing to its various therapeutic potentials. Although several studies have demonstrated the anti-inflammatory activity of this fungus, its underlying mechanisms have not yet been clearly defined.MethodsIn the present study, we have demonstrated the anti-inflammatory effects of ethanol extract of P. cocos (EEPC) in lipopolysaccaride (LPS)-stimulated RAW 264.7 macrophages. As inflammatory parameters, the productions of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-1β and tumor necrosis factor (TNF)-α were evaluated. We also examined the EEPC’s effect on the nuclear factor-kappaB (NF-κB) signaling pathway.ResultsOur results indicated that EEPC exhibits a potent inhibitory effect on NO production and inhibits PGE2 release in LPS-induced macrophages without affecting cell viability. EEPC also significantly attenuated LPS-induced secretion of inflammatory cytokines IL-1β and TNF-α. Additionally, LPS-induced expression of inducible NO synthase (iNOS), cyclooxygenase (COX)-2, IL-1β, and TNF-α was decreased by pre-treatment with EEPC at the transcriptional level. Moreover, EEPC clearly inhibited LPS-induced nuclear translocation of NF-κB p65 subunits, which correlated with EEPC’s inhibitory effects on inhibitor kappaB (IκB) degradation. Moreover, EEPC clearly suppressed the LPS-induced DNA-binding activity of NF-κB, as well as the nuclear translocation of the NF-κB p65, which correlated with EEPC’s inhibitory effects on inhibitor kappaB (IκB) degradation.ConclusionsTaken together, our data indicates that EEPC targets the inflammatory response of macrophages via inhibition of iNOS, COX-2, IL-1β, and TNF-α through inactivation of the NF-κB signaling pathway, supporting the pharmacological basis of P. cocos as a traditional herbal medicine for treatment of inflammation and its associated disorders.

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Assessment of anti‐inflammatory activity of Poria cocos in sodium lauryl sulphate‐induced irritant contact dermatitis

Cited by 36 publications

References 20 publications

Inhibitory effect of Kyungohkgo in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Inhibitory effect of Kyungohkgo in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Herbal formula FBD extracts prevented brain injury and inflammation induced by cerebral ischemia–reperfusion

Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages

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