Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil

Bostancıoğlu, Rakibe Beklem; Kürkçüoğlu, Mine; Başer, Kemal Hüsnü Can; Koparal, Ayşe Tansu

doi:10.1016/j.fct.2012.03.074

Cited by 56 publications

(48 citation statements)

References 37 publications

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“…A recent study demonstrated the capacity of Origanum onites (Lamiaceae) essential oil (OOEO) in the inhibition of cancer cell viability and proliferation and in the in vitro inhibition of tube formation and migration of rat adipose tissue endothelial cells (RATEC). The latter property indicates its capacity of blocking angiogenesis . The authors showed that the cytotoxicity values of OOEO are much higher on cancer cells, which is one of the characteristics that must be considered as a standard parameter that will allow the use of essential oils in the prevention and treatment of disease.…”

Section: Other Bioactive Properties Of Essential Oilsmentioning

confidence: 99%

Major bioactivities and mechanism of action of essential oils and their components

Saad

Muller

Lobstein

2013

Flavour & Fragrance J

205

126

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Essential oils are gaining increasing interest for their antimicrobial and antiviral properties, as well as for their preventive and therapeutic actions against many human pathologies. Herein, we present an overview on new discoveries in essential oil research, discussing antimicrobial activity, as well as immunomodulatory, anti‐apoptotic, anti‐angiogenic and anti‐tumoural properties. In addition, we emphasize recent advances in the identification of bioactive components and understanding of their mechanism of action. We discuss their molecular diversity and wide spectrum of activity as well as their structure–activity relationships and capability of targeting paradoxical responses triggered by different genes and pathways. Finally, we emphasize the effort required to isolate and identify the bioactive components of essential oils and to determine their cytotoxicity as their specificity. Thus, new approaches to specifically address bioactive components to selected targets could enhance the latter property in order to accommodate any cytotoxicity towards dysfunctioning loci. Copyright © 2013 John Wiley & Sons, Ltd.

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Section: Other Bioactive Properties Of Essential Oilsmentioning

confidence: 99%

Major bioactivities and mechanism of action of essential oils and their components

Saad

Muller

Lobstein

2013

Flavour & Fragrance J

205

126

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“…O. onites has been used as crude drug for the treatment of gastrointestinal diseases, bronchitis, respiratory tract diseases, flu, hypertension, tachycardia, convulsive coughs, menstrual problems, dizziness, diabetes, high cholesterol, stomach disorders, leukemia, flu, abdominal ache, toothache, headache, and itching . It is also used as natural antispasmodic, antimicrobial, expectorant, carminative, stimulant, analgesic, antitussive, sedative, antiparasitic, and antihelmintic agents .…”

Section: Medicinal Propertiesmentioning

confidence: 99%

“…Infusions obtained from the aerial parts are effective for treating gastrointestinal diseases, bronchitis, respiratory tract diseases, flu, hypertension, tachycardia, dizziness, diabetes, high cholesterol, stomach disorders, and leukemia . H 2 O extract and essential oil have been used for the treatment of many ailments, such as convulsive coughs, digestive disorders, menstrual problems, diabetes, and high cholesterol . They are also used as stimulant, analgesic, antitussive, expectorant, sedative, antiparasitic, antihelmintic, topically as a general antiseptic, astringent, and as an oral antiseptic for gargling .…”

Section: Medicinal Propertiesmentioning

confidence: 99%

“…Antiproliferative, antiangiogenic, cell growth and migration inhibiting, apoptotic, and cytoprotective activities of the essential oil of O. onites were investigated on rat adipose tissue endothelial cells, (RATECs), c‐H‐ras transformed rat embryonic fibroblasts (5RP7), hepatoma G2 (Hep G2) cells, and N‐ras transformed myoblast cells (CO25) by MTT, tube formation, migration, DAPI staining, and immunoblotting assays .…”

Section: Pharmacologymentioning

confidence: 99%

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Medicinal Uses, Phytochemistry, and Pharmacology of Origanum onites (L.): A Review

Tepe

Çakır

Tepe

2016

Chemistry & Biodiversity

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Origanum onites L., known as Turkish oregano, has great traditional, medicinal, preservative, and commercial importance. It is used for the treatment of several kinds of ailments, such as gastrointestinal disorders, diabetes, high cholesterol, leukemia, bronchitis, etc. In this review, traditional use, phytochemistry, and pharmacology of O. onites reported between 1988 and 2014 were discussed. This review was prepared based on literature survey on scientific journals and books from libraries and electronic sources, such as Web of Science, PubMed, Scopus, Google Scholar, etc. All databases were searched up to June 2014. Several different classes of terpenoids, triterpene acids, phenolic acids, hydroquinones, flavonoids, hydrocarbons, sterols, pigments, fatty acids, tocopherols, and inorganic compounds were detected mainly in the aerial parts of this plant. Pharmacological studies revealed that extracts obtained from several solvents and individual compounds exhibited antimicrobial, antiviral, antioxidant, insecticidal, anticancer, hepatoprotective, genotoxic, antidiabetic, cholinesterase inhibitory, anti-inflammatory, analgesic activities, etc. O. onites, in general, exhibited remarkable activity potential in almost all test systems. The results of toxicity studies indicated that O. onites did not show any significant toxicity and mutagenicity on Drosophila and Salmonella. Toxicity of the extracts/essential oils and also individual compounds should be evaluated on mammalian cells to ensure their safety. The bioactivity of individual compounds aside from terpenoids should also be assessed in detail. Additionally, mode of action for the bioactive compounds should be evaluated to understand the complex pharmacological effects of these phytochemicals.

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“…The antioxidant activity of O. onites EO was confirmed for cisplatin-induced hepatotoxicity in 96 Wistar white male rats [31]. Investigations of the ability to inhibit cell migration and antiangiogenic (prevention of new blood vessels capable of supporting tumor growth in vitro), antiproliferative [using MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide), and apoptotic (DAPI coloration) activities in rat fatty tissue endothelial cells and 5RP7 cell culture (c-H-ras transformed rat embryo fibroblasts) found that O. onites EO inhibited markedly the vitality and induced 5RP7 apoptosis and could also block in vitro formation of vessels and RATEC migration [32]. Thus, O. onites EO and its principal constituents possessed antioxidant activity and inhibited carcinogenesis.…”

mentioning

confidence: 98%

Phytochemical Study of Essential Oil from Turkish Oregano (Origanum Onites L.) By Gas Chromatography/Mass Spectrometry

Morokhina

Попов

2015

Pharm Chem J

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The chemical composition of essential oil from Turkish oregano growing in southeastern Turkey was studied by gas chromatography/mass spectrometry. More than 70 constituents, of which 57 were identified, were detected. Oregano essential oil from this Turkish region was characterized by a high content of phenolic compounds including thymol and carvacrol (75.72% total) belonging to the menthane biosynthetic type. In addition, essential oil contained linalool (4.42%), p-cymene (3.36%), borneol (2.35%), 4-terpineol (1.74%), a-bisabolene (1.24%), anethole (1.12%), caryophyllene oxide (1.10%), b-caryophyllene (0.68%), b-terpineol (0.55%), spathulenol (0.55%), carvone (0.51%), t-terpinene (0.44%), o-acetylthymol (0.43%), etc. Taking into account the high contents of these compounds in essential oil, Turkish oregano could be recommended for further study as a promising aromatic plant for non-black-earth zones of the RF.Essential oils (EOs) that are used as antifungal, antibacterial, and immunostimulating drugs are currently of great interest in Russia. The uncontrolled use of antibacterial chemotherapeutics led to the spread of resistant microorganism strains. It was also noted in clinical practice that such drugs are often the cause of allergic and immunological diseases. Biologically active compounds (BACs) of plant origin, in particular EOs, lack such drawbacks. This fact was explained by the variable chemical compositions of EOs. The fraction of each constituent changes over rather broad limits even for plants belonging to the same species and depends on the habitat, vegetation stage, collection time, raw-material storage times and conditions, and processing technology. The risk of developing resistant pathogenic microorganisms decreases significantly owing to the broad variability of the EO composition. This allows several basic problems related to the selection of effective therapeutic agents to be resolved [1]. However, the variable EO constituent composition is a serious hindrance to standardization, for which only physicochemical parameters become insufficient. Therefore, the International Organization for Standardization (ISO) recommends that modern methodical methods for recording the chromatographic profile be used for quality control [2]. This method of fingerprints allows the studied sample to be clearly characterized and the product quality to be subsequently evaluated [3]. Specifications for EOs are contained in the European Pharmacopoeia (7 th Ed.), the British Pharmacopoeia (BP), and the USA pharmacopeia (USP) [4 -6]. EOs corresponding to pharmacopoeial standards should contain a constant amount of principal BAC to ensure stable therapeutic activity.Chromatographic analysis is the most promising and informative method for studying EOs. Gas chromatography (GC), being an effective separation method, makes it possible to study terpenoids of EOs in the minimum amount of time, with highly accurate identification of compounds in multicomponent mixtures, and with an insignificant analyzed sample volume [7]. The...

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Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil

Cited by 56 publications

References 37 publications

Major bioactivities and mechanism of action of essential oils and their components

Major bioactivities and mechanism of action of essential oils and their components

Medicinal Uses, Phytochemistry, and Pharmacology of Origanum onites (L.): A Review

Phytochemical Study of Essential Oil from Turkish Oregano (Origanum Onites L.) By Gas Chromatography/Mass Spectrometry

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