Assessment of Angiographic Coronary Calcification and Plaque Composition in Virtual Histology Intravascular Ultrasound

Amano, Hideo; Ikeda, Takanori; Toda, Mikihito; Okubo, Ryo; Yabe, Takayuki; Koike, Makiko; Saito, Daiga; Yamazaki, Junichi

doi:10.1111/joic.12189

Cited by 15 publications

(7 citation statements)

References 35 publications

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“…Other studies have indicated that spotty calcification detected using OCT or IVUS was associated with greater plaque vulnerability. 26,27 In the present study, we found that spotty calcification was more common in patients with an age SI of ≥41. Therefore, we suggest that these findings may indicate greater pancoronary vulnerability and atherosclerosis, which may partly explain the higher prevalences of all-cause death and cardiac death among patients with higher age SI values.…”

Section: Non-culprit Plaque Characteristics In Patients With An Age Si Of ≥41supporting

confidence: 55%

Association of the age shock index with coronary plaque characteristics in ST‐segment elevation myocardial infarction: A 3‐vessel optical coherence tomography study

Zhao

et al. 2021

Cathet Cardio Intervent

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Objectives: We investigated whether the age shock index (SI) was associated with coronary plaque characteristics in patients with ST-segment elevation myocardial infarction (STEMI) using optical coherence tomography (OCT). Background:The age SI is a simple clinical parameter that effectively predicts poor clinical outcomes among patients with STEMI. Methods: This retrospective study evaluated 408 STEMI patients who underwent 3-vessel OCT during emergency percutaneous coronary interventions at a single center between January 2017 and October 2018. Patients were divided into groups with low or high age SI values (<41 vs. ≥41). Plaque characteristics were compared between the two groups for both culprit lesions (n = 408) and non-culprit lesions (n = 1,077).Results: In culprit lesions, patients with a high age SI (≥41) were more likely to have plaque rupture (61.0% vs. 56.8%, p = .002) and thinner fibrous caps (fibrous cap thickness [FCT]: 40.0 [33.0-53.0] μm vs. 46.0 [36.0-63.8] μm, p = .021). In nonculprit lesions, patients with a high age SI were more likely to have high-risk plaques (29.9% vs. 17.8%, p = .018; simultaneous presence of a minimal lumen area of <3.5 mm 2 , maximum lipid arc of >180 , FCT of <75 μm, and macrophage accumulation). Plaque-based analyses revealed that patients with a high age SI had larger lipid cores and lesser FCT.Conclusions: Patients with STEMI and a high age SI had increased risks of culprit plaque rupture and high-risk non-culprit plaques, and vulnerable plaque features at the culprit and non-culprit lesions. Therefore, a high age SI in patients with STEMI may indicate greater pancoronary vulnerability.

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Section: Non-culprit Plaque Characteristics In Patients With An Age Si Of ≥41supporting

confidence: 55%

Association of the age shock index with coronary plaque characteristics in ST‐segment elevation myocardial infarction: A 3‐vessel optical coherence tomography study

Zhao

et al. 2021

Cathet Cardio Intervent

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“…On the other hand, the presence of small calcifications with spotty distribution was not an independent predictor of SB complication by multivariate analysis. Spotty calcification is commonly associated with large lipid cores and it is plausible that their higher prevalence in the SBOS >50% lesions might be related to the higher lipid content of these plaques. In a recent OCT study, plaques containing spotty calcification exhibited a greater lipid index in an OCT study of stable CAD patients .…”

Section: Discussionmentioning

confidence: 99%

Plaque morphology predictors of side branch occlusion after provisional stenting in coronary bifurcation lesion: Results of optical coherence tomography bifurcation study (ORBID)

Kini

Vengrenyuk

Pena

et al. 2016

Cathet Cardio Intervent

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“…Spotty calcification has been reported to destabilize atherosclerotic plaques and increase the incidence of acute myocardial ischemia [ 64 , 65 ]. Therefore, although spotty calcification is a precursor to macrocalcification, it has serious clinical implications [ 66 ]. Future studies should focus on [Ca 2+ ] i dysregulation and vascular calcification in diabetic swine fed an atherogenic diet for a longer period of time.…”

Section: Discussionmentioning

confidence: 99%

Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

et al. 2018

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BackgroundThere is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CAD severity in animal models remains controversial. We investigated whether diabetes exacerbates CAD/CAC and intracellular free calcium ([Ca2+]i) dysregulation in the clinically relevant Ossabaw miniature swine model of MetS.MethodsSixteen swine, eight with alloxan-induced diabetes, were fed a hypercaloric, atherogenic diet for 6 months. Alloxan-induced pancreatic beta cell damage was examined by immunohistochemical staining of insulin. The metabolic profile was confirmed by body weight, complete blood panel, intravenous glucose tolerance test (IVGTT), and meal tolerance test. CAD severity was assessed with intravascular ultrasound and histology. [Ca2+]i handling in coronary smooth muscle (CSM) cells was assessed with fura-2 ratiometric imaging.ResultsFasting and post-prandial blood glucose, total cholesterol, and serum triglycerides were elevated in MetS-diabetic swine. This group also exhibited hypoinsulinemia during IVGTT and less pancreatic beta cell mass when compared to lean and MetS-nondiabetic swine. IVUS analysis revealed that MetS-diabetic swine had greater percent wall coverage, percent plaque burden, and calcium index when compared to lean and MetS-nondiabetic swine. Fura-2 imaging of CSM [Ca2+]i revealed that MetS-nondiabetic swine exhibited increased sarcoplasmic reticulum Ca2+ store release and Ca2+ influx through voltage-gated Ca2+ channels compared to lean swine. MetS-diabetic swine exhibited impaired Ca2+ efflux.ConclusionsDiabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with MetS, accompanied by progression of [Ca2+]i dysregulation in advanced CAD/CAC. These results recapitulate increased CAD in humans with diabetes and establish Ossabaw miniature swine as an animal model for future MetS/diabetes comorbidity studies.

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Assessment of Angiographic Coronary Calcification and Plaque Composition in Virtual Histology Intravascular Ultrasound

Cited by 15 publications

References 35 publications

Association of the age shock index with coronary plaque characteristics in ST‐segment elevation myocardial infarction: A 3‐vessel optical coherence tomography study

Association of the age shock index with coronary plaque characteristics in ST‐segment elevation myocardial infarction: A 3‐vessel optical coherence tomography study

Plaque morphology predictors of side branch occlusion after provisional stenting in coronary bifurcation lesion: Results of optical coherence tomography bifurcation study (ORBID)

Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

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