Assessment of Anatomical and Functional Macular Changes with Optical Coherence Tomography Angiography After Macula-Off Rhegmatogenous Retinal Detachment Repair.

Christou, Evita Evangelia; Kalogeropoulos, Chris; Georgalas, Ilias; Stavrakas, Panagiotis; Christodoulou, Eleni; Batsos, Georgios; Stefaniotou, Maria

doi:10.1080/08820538.2021.1889618

Cited by 10 publications

(11 citation statements)

References 40 publications

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“…In addition, only the PPV + gas tamponade subgroup had lower super cial parafoveal and super cial superiorhemi eld VD than the fellow eyes. Our results both in the main group which included all operated eyes and PPV + gas tamponade subgroup were consistent witht heresults of the above studies [10,11].Wang et al reporteda signi cant increase in SCP ow density over time with anatomical successful in macula off patients who underwent PPV + gas tamponade at 3 months [12].…”

Section: Discussionsupporting

confidence: 91%

“…The seresults of VD changes were consistent with our results, but FAZ was not larger in ourcases. Evita et al reported lower macular VD and larger FAZ in RRD patients with the macula off and on afterPPV + gas tamponade at postoperative 3 months when compared to thecontrol eyes [11]. In ourstudy, VD in SCP was lower than the control eyes, but FAZ was not larger both in main group and subgroups than the control eyes.…”

Section: Discussioncontrasting

confidence: 40%

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Effect of Retina Detachment Surgery at Long Time on Macular Microvascular Structure: An Optical Coherencetomographyangiography Study

Demir¹

2021

Preprint

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PurposeTo investigate the macular microvascular changes after surgery for rhegmatogenous retinal detachment(RRD) using optical coherence tomography angiography(OCTA).MethodsStudy analyzed the of 33 patients, who underwent pars plana vitrectomy(PPV) plus tamponade silicon oil(SO) or sulfurhexafluoride/perfloropropan(SF6/C3F8), or silicon band cerclage(SBC) in one eye. Operated eyes were included in group A(n=33) and fellow eyes served as control group B (n=33). The group A were created according to the type of surgery. Subgroup1: PPV+SBC+SO tamponade, subgroup 2: PPV+SF6/C3F8 tamponade, subgroup 3: PPV+SO tamponade and subgroup 4:SBC+SF6/C3F8 tamponade. Best corrected visual acuity (BCVA, log MAR), superficial and deep retinal vessel density(VD), choriocapillarisVD, foveal avascularzone(FAZ) area (mm2) and centra lmacular thickness(CMT) were evaluated using OCTA.ResultsMean postoperative follow-up time was 23±16.6 months, BCVA was 0.53±0.5 in group A, 0.01 in group B(p<0.001), in subgroups 1-4: 0.64±0.35, 0.45±0.43, 0.41±0.54, 0.40±0.76, respectively(p<0.001). Mean CMT(µm) was in groups A, B: 271±59, 261±37 (p=0.468); in subgroups 1-4: 239±46, 277±70, 273±60, 308±48, respectively(p=0.018). VD (%) in group A, B for superficial parafoveal (40.3±6.7 vs 46.9±6.2, p<0.001), superficial superiorhemifield (39.6±6.3vs 45.6±.2(p<0.001) and superficial inferiorhemifield (38.2±9.1vs 44.9±5.7(p<0.001). Mean VD in subgroups 1-4: for superficial superiorhemifield 40.25±7.8, 36.4±3.7, 40.1±6.3, 40.7±6(p=0.003); for superficial inferiorhemifield 36.0±14.5, 37.0±3.9, 40.1±5.7, 39.6±6.5p=0.019); for deep fovea 27.0±8.9, 33.6±10.3, 33.2±7.4 ,42.37±8.2(p=0.016). The mean FAZ area(mm2) in group A and B: 0.286±0.14;0.264±0.11(p=0.59), in subgroups 1-4: 0.363±0.14, 0.268±0.11, 0.221±0.13,0.279±0.13(p=0.131). ConclusionSuperficial and deepVD measurements of OCTA represented a decreasing trend following the surgery for RRD. The FAZ area was similar between theoperated and fellow eyes for a longer follow-up period.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 40%

Effect of Retina Detachment Surgery at Long Time on Macular Microvascular Structure: An Optical Coherencetomographyangiography Study

Demir¹

2021

Preprint

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“…They observed that PFCL and silicone oil decrease the vitality of RPE cells after 7 days of exposure. Moreover, they also determined that the damage caused by PFCL had a cytotoxic character, and that of silicone oil was mechanical [ 43 ], whereas in our research, we did not indicate a cytotoxic effect of oil endotamponade, which may be related to the fact that the silicone oil was removed after a maximum period of 1.5 months in all patients, among other factors. Of course, in light of the abovementioned research [ 42 , 43 ], it seems that a valuable supplement to the research would be the inclusion of a group of patients in whom oil endotamponade or gas would be removed at a later time.…”

Section: Discussioncontrasting

confidence: 73%

“…They also indicated that determining the number of ganglion cells should be the gold standard of determining an improvement or deterioration in vision after eye surgery with silicone oil tamponade [ 42 ]. Furthermore, Inoue et al [ 43 ] assessed the influence of perfluorocarbon liquid (PFCL) and silicone oil on human retinal pigment epithelium (RPE) cells and retinal ganglion cells (RCGs), except under in vitro conditions. They observed that PFCL and silicone oil decrease the vitality of RPE cells after 7 days of exposure.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment

Lyssek-Boroń

Wylęgała

Krysik

et al. 2021

JCM

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The aim of this study was to investigate the changes in the retinal capillary plexuses in patients after pars plana vitrectomy (PPV), which is used for the treatment of rhegmatogenous retinal detachment (RRD). In this study, we included the results of 114 patients who underwent PPV after total retinal detachment (RRD; retinal detachment group). It should be kept in mind that to qualify for the study group, there was a condition that retinal detachment be only present in one eye, allowing the fellow healthy eye to be used for the control group, and the study, therefore, did not include cases where retinal detachment occurred binocularly. Optical coherence tomography (OCT) and OCT-A images were taken at 9 ± 2 months (median 10 months) after the surgery, with the study conducted in the years 2017–2019. OCT was used to examine the external limiting membrane (ELM), central macular thickness (CMT) and retinal nerve fiber layer (RNFL), while OCT-angiography (OCT-A) was used to examine the extent of the foveal avascular zone (FAZ) in the deep and superficial capillary plexuses. Changes in the FAZ area of the superficial plexus (SCP) between the study and control groups were analyzed over 346 ± 50 days. In our study, we observed changes in the FAZ area between the RRD and control groups in the SCP (203.65 ± 31.69 μm2 vs. 215.30 ± 35.82 μm2; p = 0.28733) and DCP (284.79 ± 35.82 µm2 vs. 336.84 ± 32.23 µm2; p = 0.00924). Changes in the RNFL thickness between the study and control groups over 346 ± 50 days were as follows: 90.15 μm vs. 82.44 μm; p = 0.19773. Disruption of the external limiting membrane was observed in 78.95% (90 eyes) of the study group. In the control group, it was undamaged, and no integrity disorder was observed. In the RRD, changes occurred in the FAZ of both the SCP and the DCP, which reduced the extent of this zone, an effect that was more pronounced in DCPs. A better understanding of the anatomical and hemodynamic changes taking place in the retina after macula-off RRD might be helpful in answering the question as to why BCVA in these cases is “only” or “as much as” from 0.4 to 0.1, namely, that it might be related to changes in the neurosensory retina after macular peeling.

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“… 39 – 44 Nonetheless, Maqsood et al 29 reported a larger FAZ area in SCP of SO-filled eyes compared with DCP, possibly attributable to the longer preoperative duration of macular detachment than that of former studies (20.5 and 10 days in Maqsood’s and Roohipoor’s study, respectively). 29 , 36 In our present study, the FAZ SCP was significantly larger along with diminished circularity in macula-off eyes treated with SO than the fellow eyes at 1 month after operation. Our findings could imply vascular insufficiency in eyes with SO tamponade, which could reflect potential ischemic changes to retinal capillary plexus in the macula, including fovea, parafoveal, and perifoveal area despite relatively expeditious surgery (within 8.2 days from presentation).…”

Section: Discussionsupporting

confidence: 53%

Macular microcirculation changes after macula-off rhegmatogenous retinal detachment repair with silicone oil tamponade evaluated by OCT-A: preliminary results

et al. 2022

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Background: Rhegmatogenous retinal detachment (RRD) with macular involvement is a sight-threatening condition. Silicone oil (SO) is efficacious for retinal tamponade, especially in complex cases. Whether macular detachment per se or the potential tamponading agent may affect macular microcirculation after RRD repair is a matter of research. Objectives: To investigate macular microcirculation changes using optical coherence tomography angiography (OCT-A) after pars plana vitrectomy (PPV) with intravitreal SO for RRD repair in the early posttreatment period. Design: Prospective comparative cross-sectional study. Data sources and Methods: Fourteen eyes of 14 patients were included in the study. All eyes underwent a single successful PPV with SO tamponade for macula-off RRD. OCT-A was performed to analyze macular microcirculation and visual outcomes at 1 month postoperatively. The fellow unaffected eye was used as control. Results: Vessel density (VD) in the superficial capillary plexus (SCP) was significantly lower at each macular region (fovea, parafovea, and perifovea) of SO-treated eyes compared with the fellow eyes (all p = 0.001). Similarly, perfusion density (PD) in the SCP was significantly lower at each macular region than the fellow eyes (all p = 0.001). There was enlargement of foveal avascular zone (FAZ) area and decrease of circularity at RRD eyes compared with the fellow ones (all p = 0.001). Postoperative logMAR visual acuity (VA) was significantly lower in treated eyes than fellow eyes and correlated inversely with foveal, parafoveal, and perifoveal VD and PD SCP (all p < 0.001). Postoperative VA had no correlation with FAZ parameters. Conclusion: Enlargement of FAZ SCP and decrease in VD and PD SCP during the short-term follow-up were possibly attributable to ischemic changes in the macular area after RRD repair with SO tamponade. In this preliminary study, the flow density in macular capillary plexus may represent an indicator of visual outcomes.

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Assessment of Anatomical and Functional Macular Changes with Optical Coherence Tomography Angiography After Macula-Off Rhegmatogenous Retinal Detachment Repair.

Cited by 10 publications

References 40 publications

Effect of Retina Detachment Surgery at Long Time on Macular Microvascular Structure: An Optical Coherencetomographyangiography Study

Effect of Retina Detachment Surgery at Long Time on Macular Microvascular Structure: An Optical Coherencetomographyangiography Study

Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment

Macular microcirculation changes after macula-off rhegmatogenous retinal detachment repair with silicone oil tamponade evaluated by OCT-A: preliminary results

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