Assessment of an AI virtual staining model performance across same and serial tissue sections using CD3+T cell ground truth
Abu Bakr Azam,
Felicia Wee,
Juha P. Väyrynen
et al.
Abstract:Immunophenotyping via multi-marker assays significantly contributes to patient selection, therapeutic monitoring, biomarker discovery, and personalized treatments. Despite its potential, the multiplex immunofluorescence (mIF) technique faces adoption challenges due to technical and financial constraints. Alternatively, hematoxylin and eosin (H&E)-based prediction models of cell phenotypes can provide crucial insights into tumor-immune cell interactions and advance immunotherapy. Current methods mostly rely… Show more
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