Assessment of ammonium fluoride as a mobile phase additive for sensitivity gains in electrospray ionization
Jeremy Ryan McFadden,
David Michael Ames
Abstract:Ammonium fluoride has been shown to improve sensitivity when using electrospray ionization (ESI) coupled with mass spectrometry (MS). Recent internal investigation furthered that claim, through the observation of improved sensitivity when analyzing steroid molecules. This work focuses on extending those observations to other small molecules to understand the impact ammonium fluoride has on detection sensitivity with optimized instrument conditions. Using conventional liquid chromatography ESI‐MS we investigate… Show more
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