Assessment of Age-Related Changes of Salivary Immunoglobulin a Levels among Healthy Individuals

Shete, Manishkumar Dinkar; Patil, Dipak Baliram; Karade, Priyatam; Chopade, Rutuja; Gandhi, Neha; Alane, Uddhav

doi:10.4103/jpbs.jpbs_605_20

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…IgA is a class of antibodies found in the mucous membranes, which is the body's first defence factor in contact with an infectious pathogen or an allergen [28]. The salivary IgA levels increased with increasing age up to 60 years and then decreased [29]. sIgA peaks in the morning and then gradually declines till the evening [30].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

et al. 2023

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Background and objectives: In psoriatic patients, stress is the most common aggravating factor. Despite the use of quality-of-life assessment questionnaires, diagnosing stress in psoriatic patients is not a flawless procedure. This study aimed to assess the usefulness of potential stress biomarkers in saliva for monitoring the treatment of psoriasis. Materials and methods: A total of 104 adult patients with severe psoriasis were included and randomly treated via biological treatment or symptomatic therapy: 84 received biological treatment, with 20 formed a control group receiving symptomatic therapy. The administered biological treatment was adalimumab, whilst in controls calcipotriol/betamethasone dipropionate topical gel and emollients were used. Patients were monitored monthly with a dermatological examination and the dispensing of a biological drug. During each of the four visits, the severity of the disease was assessed (PASI, BSA, and DLQI), and a sample of the patient’s saliva was taken. In all the participants, the saliva concentrations of immunoglobulin A (sIgA), α-amylase (sAA), and chromogranin A (CgA) were measured. Results: The majority of patients in both the study and control groups achieved clinical improvement, though favoring the group receiving biological treatment. The concentration of sIgA in the saliva was constantly increasing in the study group during subsequent visits (Fr = 27.26; p < 0.001). Meanwhile, there were no statistically significant changes in the control group during the same follow-up period (Fr = 6.66; p = 0.084). Levels of sAA underwent statistically significant changes in both groups (Fr = 58.02; p < 0.001—study group and Fr = 13.74; p = 0.003—control group). In the study group, a steady, statistically significant increase in sAA was observed from the first to the third visit. In the study group, a downward trend in CgA concentration was observed. In the control group, no significant differences in the level of CgA were obtained. Conclusions: sIgA, sAA, and CgA are potential markers of the severity of psoriasis and the associated stress reaction. Based on the presented observations, only sIgA and CgA seem to be valuable biomarkers for monitoring the effectiveness of the systemic treatment of psoriasis.

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Section: Discussionmentioning

confidence: 99%

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

et al. 2023

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Correlation Depending on Age Between Saliva and Plasma Parameters

et al. 2022

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Introduction. Because of the increasing interest in the study of saliva, many methods have become available that can allow us to perform multiple and rapid analyzes of the composition of salivary secretion using advanced techniques of nanotechnology and fluid micro- engineering. The objectives of our study were to identify immunoglobulin levels variations with age. Materials and methods. We conducted an analysis to check the correlation between saliva and plasma parameters on 24 patients. The study population was divided into 2 groups based on age, with a cut-off at 35 years. The differences on the variables between two groups were evaluated by TTEST and CORREL. Results. Total plasma calcium, as well as ionic calcium have increased values in group 2, the increase being statistically significant (p =0.04) only for ionic calcium. Significant correlation of plasma and salivary values in the case of IgA / IgG ratio, and also a significant correlation of salivary and plasma concentrations for IgG were identified in our study. Conclusions. The correlation between plasma and salivary parameters is closely related to age and these can be used as markers for diagnosis and evaluation of various pathologies. Also, regarding women, salivary calcium and phosphate concentrations increase with age showing peak values around menopause.

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Assessment of Age-Related Changes of Salivary Immunoglobulin a Levels among Healthy Individuals

Cited by 2 publications

References 17 publications

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

Correlation Depending on Age Between Saliva and Plasma Parameters

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